ID Q4QA88_LEIMA Unreviewed; 544 AA.
AC Q4QA88;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Poly(A)-binding protein 3 {ECO:0000313|EMBL:CAJ04400.1};
GN Name=PABP3 {ECO:0000313|EMBL:CAJ04400.1};
GN ORFNames=LMJF_25_0080 {ECO:0000313|EMBL:CAJ04400.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ04400.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ04400.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ04400.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC {ECO:0000256|ARBA:ARBA00008557}.
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DR EMBL; FR796421; CAJ04400.1; -; Genomic_DNA.
DR RefSeq; XP_001683760.1; XM_001683708.1.
DR AlphaFoldDB; Q4QA88; -.
DR STRING; 5664.Q4QA88; -.
DR EnsemblProtists; CAJ04400; CAJ04400; LMJF_25_0080.
DR GeneID; 5652412; -.
DR KEGG; lma:LMJF_25_0080; -.
DR VEuPathDB; TriTrypDB:LmjF.25.0080; -.
DR VEuPathDB; TriTrypDB:LMJFC_250006100; -.
DR VEuPathDB; TriTrypDB:LMJLV39_250005900; -.
DR VEuPathDB; TriTrypDB:LMJSD75_250005800; -.
DR eggNOG; KOG0123; Eukaryota.
DR HOGENOM; CLU_012062_22_4_1; -.
DR InParanoid; Q4QA88; -.
DR OMA; QQPGFMP; -.
DR Proteomes; UP000000542; Chromosome 25.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:GeneDB.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0031370; F:eukaryotic initiation factor 4G binding; IDA:GeneDB.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0008143; F:poly(A) binding; IDA:GeneDB.
DR GO; GO:0008266; F:poly(U) RNA binding; IBA:GO_Central.
DR CDD; cd00590; RRM_SF; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR Gene3D; 1.10.1900.10; c-terminal domain of poly(a) binding protein; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR24012:SF491; POLYADENYLATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR24012; RNA BINDING PROTEIN; 1.
DR Pfam; PF00658; PABP; 1.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF63570; PABC (PABP) domain; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS50102; RRM; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 8..89
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 99..176
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 188..267
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 289..368
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 466..543
FT /note="PABC"
FT /evidence="ECO:0000259|PROSITE:PS51309"
SQ SEQUENCE 544 AA; 60900 MW; 9DE43713D4F08EBA CRC64;
MVAPAQRTSV YVGDLPIDLP RPEEAINNLF STVAPVVSVK VCRDMATQRS LGYGYVNFQT
TADAEKVIDA LNYTGIAPGR QIRVMFSIRD PLQRKSGMNN VFVKKLDTAI NAKELQAAFS
KCGRVLSCKV ALDSAGNSKG YGFVQFETAD GTKAALEMNG SKLGDSEVVV APFVRRVDRE
AMAAKSFRNI YIKNITASAT EADVKAIVEE FGKVDSLFLS EHARFPTKFA LVAFEEHQAA
VQAIAALNES EESGLTEKAV KLVVCRALSK SERDREKKKA ASLYQNHGRN LYIKHLPDDI
TDDRLREIFE PFGKITSCAI MKEPNGTLKG FAFVCFEDKQ HASAALRSLN GHPLEHSAKP
LYVSHAEQKD MRIRLLQQRR AAMRHQSRMA PLMNTFPQQW PRHPFPHMVP PMMPPPPPPN
MGMPQFMSGP MIRRPVMEPH LMQGEPMRPP NRYTQAREQY PPQQRQDGVD MNYLSTLSPE
QQKNYLGELL YSRILPLESS NAAKITGMLL EMSREEIFEI LADHFALLSK IQEANAVLQQ
HTGN
//
