ID Q4QD81_LEIMA Unreviewed; 691 AA.
AC Q4QD81;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Putative glycerol uptake protein {ECO:0000313|EMBL:CAJ07225.1};
GN ORFNames=LMJF_19_1000 {ECO:0000313|EMBL:CAJ07225.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ07225.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ07225.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ07225.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FR796415; CAJ07225.1; -; Genomic_DNA.
DR RefSeq; XP_001682717.1; XM_001682665.1.
DR AlphaFoldDB; Q4QD81; -.
DR STRING; 5664.Q4QD81; -.
DR EnsemblProtists; CAJ07225; CAJ07225; LMJF_19_1000.
DR GeneID; 5651239; -.
DR KEGG; lma:LMJF_19_1000; -.
DR VEuPathDB; TriTrypDB:LmjF.19.1000; -.
DR VEuPathDB; TriTrypDB:LMJFC_190022800; -.
DR VEuPathDB; TriTrypDB:LMJLV39_190019000; -.
DR VEuPathDB; TriTrypDB:LMJSD75_190019100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_190019200; -.
DR eggNOG; KOG3860; Eukaryota.
DR HOGENOM; CLU_360356_0_0_1; -.
DR InParanoid; Q4QD81; -.
DR OMA; TPWFATG; -.
DR Proteomes; UP000000542; Chromosome 19.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016746; F:acyltransferase activity; IBA:GO_Central.
DR InterPro; IPR004299; MBOAT_fam.
DR PANTHER; PTHR13285; ACYLTRANSFERASE; 1.
DR PANTHER; PTHR13285:SF18; PROTEIN-CYSTEINE N-PALMITOYLTRANSFERASE RASP; 1.
DR Pfam; PF03062; MBOAT; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 135..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 405..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 502..526
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..606
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 78..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 78450 MW; 451AD292AAC52BBA CRC64;
MILYGFAAIR DFCDRHAKYY WSKLVYPTPL FLRLGTNGYD NFTDKQWTGF CGQYSKLLAV
ALLLGAWSAL CRHSRASSPL NVSSSPLSSS SSQLSSVTTG KQRTAIGERR FQGTPLAPAY
RFCSEAASTR ATRVILYRSS WIPAFYTIVG VVFVIVVHGP HFFLPLLIII ANYVIFSRLQ
RWCPYWLFMV IMWSTHVTLL YLIEINDGFE QAYWLQYFAP TSKKVAWAVL AEVRIPLWKQ
RMRWSVAFRM STLRLIAFNY DLWEATHAAA RARDRATAKH DTSCVECAQL REQNAASAAA
LPAEASRCYK YRTEYARDPA DYNFLNYAAY VLFPPLYLAG PMSSFNAFVS YMRVPSTSMP
LRKMVRYALS ILRIYMTEYV LLHFIHVNAI ATHPFLLLRM TLLEQAHFLV YMLAYMWLKF
SFIWKSSRLF AMLSGIDVPE DMRRCFGNTL TVRGFWRDWH ASFNLWIVRY MYIPMGGRSR
VALSVLPIFL FIAVWHDPAL HLVKWAVCIA AMFVAEVAVS GCFGWAAAAF RHEMAAAAPA
GEASGAALEN GRPAHCAPCR SLLARLARLS ARRLSPRTRA WLHRQIRVVG GMSTVFALIV
ANLIGFSMQN SSATIAKIGT TLEPTDAEDI IARSFSQWTP WFATGLLVSL YTLSSLAVID
RDMQAHMMSW LRHQYKLNKS ASEATPAEGR T
//
