ID Q4QDR4_LEIMA Unreviewed; 316 AA.
AC Q4QDR4;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Mitochondrial carrier protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LMJF_18_1265 {ECO:0000313|EMBL:CAJ04115.1}, LMJF_18_1270
GN {ECO:0000313|EMBL:CAJ04117.1}, LMJF_18_1275
GN {ECO:0000313|EMBL:CAJ04120.1}, LMJF_18_1285
GN {ECO:0000313|EMBL:CAJ04128.1}, LMJF_18_1290
GN {ECO:0000313|EMBL:CAJ04130.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ04117.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ04117.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ04117.1}, and MHOM/IL/81/Friedlin
RC {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ04117.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ04117.1}, and MHOM/IL/81/Friedlin
RC {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
RN [3] {ECO:0000313|EMBL:CAJ04117.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Friedlin {ECO:0000313|EMBL:CAJ04117.1};
RA Aslett M.;
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC {ECO:0000256|ARBA:ARBA00006375, ECO:0000256|RuleBase:RU000488}.
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DR EMBL; FR796414; CAJ04115.1; -; Genomic_DNA.
DR EMBL; FR796414; CAJ04117.1; -; Genomic_DNA.
DR EMBL; FR796414; CAJ04120.1; -; Genomic_DNA.
DR EMBL; FR796414; CAJ04128.1; -; Genomic_DNA.
DR EMBL; FR796414; CAJ04130.1; -; Genomic_DNA.
DR RefSeq; XP_001682533.1; XM_001682481.1.
DR RefSeq; XP_001682534.1; XM_001682482.1.
DR RefSeq; XP_001682535.1; XM_001682483.1.
DR RefSeq; XP_001682537.1; XM_001682485.1.
DR RefSeq; XP_001682538.1; XM_001682486.1.
DR AlphaFoldDB; Q4QDR4; -.
DR EnsemblProtists; CAJ04115; CAJ04115; LMJF_18_1265.
DR EnsemblProtists; CAJ04117; CAJ04117; LMJF_18_1270.
DR EnsemblProtists; CAJ04120; CAJ04120; LMJF_18_1275.
DR EnsemblProtists; CAJ04128; CAJ04128; LMJF_18_1285.
DR EnsemblProtists; CAJ04130; CAJ04130; LMJF_18_1290.
DR GeneID; 5651055; -.
DR GeneID; 5651056; -.
DR GeneID; 5651057; -.
DR GeneID; 5651059; -.
DR GeneID; 5651060; -.
DR KEGG; lma:LMJF_18_1265; -.
DR KEGG; lma:LMJF_18_1270; -.
DR KEGG; lma:LMJF_18_1275; -.
DR KEGG; lma:LMJF_18_1285; -.
DR KEGG; lma:LMJF_18_1290; -.
DR VEuPathDB; TriTrypDB:LmjF.18.1260; -.
DR VEuPathDB; TriTrypDB:LMJFC_180020400; -.
DR VEuPathDB; TriTrypDB:LMJLV39_180018400; -.
DR VEuPathDB; TriTrypDB:LMJSD75_180018700; -.
DR eggNOG; KOG0759; Eukaryota.
DR HOGENOM; CLU_015166_14_1_1; -.
DR InParanoid; Q4QDR4; -.
DR OMA; GPSCMRA; -.
DR Proteomes; UP000000542; Chromosome 18.
DR GO; GO:0097014; C:ciliary plasm; ISO:GeneDB.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0020023; C:kinetoplast; ISO:GeneDB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; ISO:GeneDB.
DR GO; GO:0005654; C:nucleoplasm; ISO:GeneDB.
DR GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
DR GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
DR GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
DR GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
DR GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
DR Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR InterPro; IPR023395; Mt_carrier_dom_sf.
DR PANTHER; PTHR45618:SF9; MITOCHONDRIAL 2-OXOGLUTARATE_MALATE CARRIER PROTEIN; 1.
DR PANTHER; PTHR45618; MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED; 1.
DR Pfam; PF00153; Mito_carr; 3.
DR SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR PROSITE; PS50920; SOLCAR; 3.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PROSITE-
KW ProRule:PRU00282}; Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|PROSITE-
KW ProRule:PRU00282};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000488}.
FT TRANSMEM 18..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 20..95
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 114..199
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
FT REPEAT 212..303
FT /note="Solcar"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00282"
SQ SEQUENCE 316 AA; 34238 MW; 6E4C3C4401C13377 CRC64;
MSPQTASAPK APAPPLPLWQ TLGVSGFAGM FGWCFTHPFE MWKNTVMMAA PGTSQLDSLK
ATARKGFYTG LSSGLMRQLI YTTARLGFYP SFRDGILEGE VALGLKRSAD PAGATALDRA
LAGASAGVFA SFLSSPVEVC LVLQTTSKGK ERLSMLQACN SVLKSRGVTG LWSGFGALAS
RAALVGVSQV AVHDQVLTML RKRNVKRADP LGDNVVVNIA SVITALFCSI VTMPMEVARV
RMSAEAKLSA GAERRYHNVV QCIGRIFKEE GLLAMYDSYL PYFSRCASQT VICFFVIEYL
TRELRERQKA KTNLIK
//
