ID Q4QE80_LEIMA Unreviewed; 1430 AA.
AC Q4QE80;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Putative kinesin {ECO:0000313|EMBL:CAJ03849.1};
DE EC=3.6.4.4 {ECO:0000313|EMBL:CAJ03849.1};
GN ORFNames=LMJF_17_1110 {ECO:0000313|EMBL:CAJ03849.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ03849.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ03849.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ03849.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. Ungrouped subfamily.
CC {ECO:0000256|ARBA:ARBA00010103}.
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DR EMBL; FR796413; CAJ03849.1; -; Genomic_DNA.
DR RefSeq; XP_001682368.1; XM_001682316.1.
DR STRING; 5664.Q4QE80; -.
DR EnsemblProtists; CAJ03849; CAJ03849; LMJF_17_1110.
DR GeneID; 5650842; -.
DR KEGG; lma:LMJF_17_1110; -.
DR VEuPathDB; TriTrypDB:LmjF.17.1110; -.
DR VEuPathDB; TriTrypDB:LMJFC_170019600; -.
DR VEuPathDB; TriTrypDB:LMJLV39_170018400; -.
DR VEuPathDB; TriTrypDB:LMJSD75_170018100; -.
DR eggNOG; KOG0240; Eukaryota.
DR HOGENOM; CLU_258537_0_0_1; -.
DR InParanoid; Q4QE80; -.
DR OMA; DWRCNPQ; -.
DR Proteomes; UP000000542; Chromosome 17.
DR GO; GO:0005930; C:axoneme; ISO:GeneDB.
DR GO; GO:0097542; C:ciliary tip; ISO:GeneDB.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR CDD; cd00106; KISc; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR PANTHER; PTHR24115:SF287; PUTATIVE-RELATED; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00185; ARM; 4.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000313|EMBL:CAJ03849.1};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 8..345
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 401..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1243..1372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 359..386
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1245..1274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1302..1319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1352..1372
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 93..100
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1430 AA; 158166 MW; C77FB795823A69F3 CRC64;
MSTAVVSRPR VYVRIRPLND REVRDGKGEL ACRGDTRQQD LLFLKKDETL EQQVRFDQVF
DQRSNQQLVF DHIGPEILRT LFSGYNASVF AYGQTGSGKT YTMEGDKGGG VSGGASSEEQ
EGLIPRIIRG IFSSFKSNAD ITDALVEVSL VQIYQERIQD LLNHRKQVEI HMDRTSQYVA
RDATWRTVRS LEECMKLYGE ACKMRATSAT EMNLVSSRSH MILMLRMQWD EPALPGSHAQ
LNMIDLAGSE RLSESGATGE SMKETITINK SLSALGNVVV KLVEQAKKPN KRIHIPYKDS
KLTYLLQSSL GGANLVHFML AVSGSAMWRS ETTSTIEFGK RALQLVLRPV RNAIDYTRLA
EMEAMIERMR SHIESLEEEL QLKRNFEAAG FLQLRQIAQS DDDPVQRRRR HETSTNHKHL
KRQTELTRIM ANLPETFDDL TSHCVLFPES KVTFRELGGL EKLIYFVEKC ASNYYRASAA
QTIASVIDEP GREVFASLGG LNALAVLLRV QEERCKEAAC VALEAVCRGC VTNKRSLSTD
VYAELVDLVY GYSNQQVQEA ACAAVASIVD GYAEATRRFE RLDVVPKLLE TIRTCPAEVV
NLTKAATNCV GRLAHGDKDM QQTIASLGGV DLLIDVLFSS SGDRDHQVPI LASYALVNLC
CSSHENLKMA MEHSRYGEVK FRLLEGLARA FGTNASREGF GRATAQETAG PFPYYGVTIQ
DEWTYASSGG RPIFSTFMDN PQFHLYVREE TDIAFIIQDT LYEARMRKKR RNNSVYMGIA
IFEGEPTLAK LGLKQLDFHG KMIEIGHYTS NCENVLHCTL PASDTPYMVV PFTSQKGRRT
HFALSAFGNH PIELTSVPDQ VGWVHTVLQG KWTEFTGRGG EAFDWRCNPQ IRLKTKEACR
VVFVLSYLSL DEQRAQLLQE EEEREGQNTR PRLHGRLFSN AFAAHKRYLK AIVPLPQGST
FVASNTFASN SYITTSANLD RSGDYAYIPF TEAPFQDTYR VSVYCDSDDV EIKPMQGQSS
EWMCASLSGV WQGKPVSIDL DTIGKLVAVM YSPGAFVRPR LLSGSNQKRI AGIDSYWNTE
ATVEYDSDGQ LTLQVEAMMR SGTPGAAAAR GNTQSATNQV TQVPATDIKF DLFIFTDRKC
TLTRVGFDAS PSSWPCPTQS TSLALLAYPQ LVEDVDAIGG DDEDNSDSLA SELCRDDSDS
ISAAAQEARE TELLRLLEKQ EAANHILKLQ LAQQARELEE LRNGGASATT LSNSDGKRGS
SVKPSGTKTP KRTLSATMDG YAGFSEEGHR SRKEVGGDGS AQATLRNPSS GNTSGSAETK
GAAAKPPSTG LGQRDTNTNG AGAWGQKPLP LAGTTLPTNR SGMADNTASA APSPQVKELV
DYTLVKLIEM GKRAATSARL ADKKEDRKWR AMLKDIEEVH QRLHDAFSIL
//
