ID Q4QFG8_LEIMA Unreviewed; 835 AA.
AC Q4QFG8;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=C3H1-type domain-containing protein {ECO:0000259|PROSITE:PS50103};
GN ORFNames=LMJF_15_0160 {ECO:0000313|EMBL:CAJ03240.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ03240.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ03240.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ03240.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796411; CAJ03240.1; -; Genomic_DNA.
DR RefSeq; XP_001681930.1; XM_001681878.1.
DR AlphaFoldDB; Q4QFG8; -.
DR STRING; 5664.Q4QFG8; -.
DR EnsemblProtists; CAJ03240; CAJ03240; LMJF_15_0160.
DR GeneID; 5650370; -.
DR KEGG; lma:LMJF_15_0160; -.
DR VEuPathDB; TriTrypDB:LmjF.15.0160; -.
DR VEuPathDB; TriTrypDB:LMJFC_150006900; -.
DR VEuPathDB; TriTrypDB:LMJLV39_150006700; -.
DR VEuPathDB; TriTrypDB:LMJSD75_150006800; -.
DR eggNOG; ENOG502S717; Eukaryota.
DR HOGENOM; CLU_340239_0_0_1; -.
DR InParanoid; Q4QFG8; -.
DR OMA; YCAEKNT; -.
DR Proteomes; UP000000542; Chromosome 15.
DR GO; GO:0005829; C:cytosol; ISO:GeneDB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; ISM:GeneDB.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR SMART; SM00356; ZnF_C3H1; 1.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 14..42
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 14..42
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 116..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..201
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..280
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 505..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 835 AA; 85746 MW; 80E47D4DA7299582 CRC64;
MTKNRRHDIV KPSKYKTSMC TFFRSEEGCP FGEKCAFAHG EDELRPEPKD TAPLPEAATG
EAVMAAAATL LTSESPCSEH FDAKAALGDG QHSDAPAQPL QHDPSASMPA IIAGAKRRTK
KGSLDSSSAS TENAHGFPGG GPGGSGSSSA ARGDAPTTRG RALPNRRQQL PPPPLPGHGA
MPPTMFGLAV PPPPLPQPTP PSFGLSGDFG GLAYASMPVM MPGMPYYIPA MGHHPFSAIN
NNQHAINAAP VMHGSTSYPT LQHTMQLPTP PPPPPAAASS SSAPPSVTRR ANGVAAADAL
PSDDAKHRLR QPTRHVVSSN TMAHSTGRHP INASATAPDD VATPQYLYNL MAAAGALLNS
SPELASHSQP NPSVEQPAQP RLIAVPHPSG SGVCMLPSTA MSYPHSDPQS FAAFGGVAAA
SSPRHSTASM PDSSDSGLRS PQPTPTTTAS NSAAAAQFPP PDFVAATPAP VTVVQLPLNS
TSHGQSGSGS CTSKVMGDSL WSPAEGTMNP LTSSLASHSG AATSSTEEYG SSAGDYNAIL
SGLGIGGSSY TAIPLDRLMR QCSANINEDD FVGGDFDWTG AVERWLQMAR EDGVAAETAT
ANADDTPTTA AAAVATAEKT TASTPGATLA AAKNSETVAE TYHLQSGRSV MAALNSNPVL
VDMAIQSTEA NASLPAPASS ATEAKRRPIA AVCQVSRAAG GKPSQLQRRA PVTTNQFKSS
CAAEADSGAV LLYCAEKNTI VYIPSGGSGA AVAVTPGRRR GQAAATTTDW VALPQSEKKW
SATTVKAVPA LGRSQDSLNT PCSDGSLGMD VRFVPGRKKR SVLEEATEEE AEYCI
//
