ID Q4QFL7_LEIMA Unreviewed; 766 AA.
AC Q4QFL7;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Putative ras-like small GTPases {ECO:0000313|EMBL:CAJ03184.1};
GN ORFNames=LMJF_14_1170 {ECO:0000313|EMBL:CAJ03184.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ03184.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ03184.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ03184.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796410; CAJ03184.1; -; Genomic_DNA.
DR RefSeq; XP_001687717.1; XM_001687665.1.
DR AlphaFoldDB; Q4QFL7; -.
DR STRING; 5664.Q4QFL7; -.
DR EnsemblProtists; CAJ03184; CAJ03184; LMJF_14_1170.
DR GeneID; 5650321; -.
DR KEGG; lma:LMJF_14_1170; -.
DR VEuPathDB; TriTrypDB:LmjF.14.1170; -.
DR VEuPathDB; TriTrypDB:LMJFC_140019500; -.
DR VEuPathDB; TriTrypDB:LMJLV39_140019500; -.
DR VEuPathDB; TriTrypDB:LMJSD75_140019000; -.
DR eggNOG; KOG0230; Eukaryota.
DR HOGENOM; CLU_364677_0_0_1; -.
DR InParanoid; Q4QFL7; -.
DR OMA; CRVCASC; -.
DR Proteomes; UP000000542; Chromosome 14.
DR GO; GO:0097014; C:ciliary plasm; ISO:GeneDB.
DR GO; GO:0005737; C:cytoplasm; ISO:GeneDB.
DR GO; GO:0031981; C:nuclear lumen; ISO:GeneDB.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46753; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR46753:SF2; FYVE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00071; Ras; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 44..71
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 701..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 80724 MW; B29EF6AEDD3B9DB8 CRC64;
MSGNGAVQSP ALAKPVLDLS QVRCIPFDQW VPDAQVVNCM APDCSNSFSL FNRKHHCRMC
GHVFCSSCCN NLVYIPAAVV NKANSSTEGA AAAGSYSAMT NTSLSSVVTP EPQQFNRACA
SDGSALPNGM RRGPQAPAAQ GLDVSSASSS ALLPGPLPVC SDGNGHPPSN ALTAPSAVTA
LPSSMSPSTQ AAVPCRVCAS CSYEVQLVVS TRQENGEPRR RSRGELKMIQ RVLLVNVMSF
LTLRDLANVS LVSADFYFMS RDNIIWYQYN MTRWVQEAKL PRLSSHNSRA AASRMQQQRG
PSWCTYSSGS GPRSSLVDDM FSSAPVIQDA TALSESEAAK RVISLHARYN YTQFLDFARR
QEMAWCEGLS SFSLGARLLL SSPIRVALVG PCGIGKTASA HAFLGEKPSQ MVVRPTIGFE
RRAVRVRLAR GLSAEAVLHI YDLSGADRYG ELRRFVCRHC HAIGLCYDPS RKVTLVQAAD
IMMGLESALG PQPVVVCGLM RQPHHTSSSG SVPLNYHRAG PARLPAVVSA VTAVGLSAPL
VRRDQSSHAV PVGSAESAAE AAGGVAGESM LAAPICGVAN GCNTSPRASS SPAGTAVTLP
GGMAENGAHE SCDRLQADAA VSPMPSPPQP PFAVASPQSR ALEVSVEDAV GITVRGHSSI
HCPLLHPTPL FEALVQSVLD LLVEATVAST STISEISAEL TTHGSGSGPQ SFPTCCPSSL
SAGSAPANAT RVASTRRRPH ASRAIMEDLR NLTMQPCALD ILLDRK
//
