ID Q4QG15_LEIMA Unreviewed; 401 AA.
AC Q4QG15;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|Pfam:PF12706};
GN ORFNames=LMJF_13_1390 {ECO:0000313|EMBL:CAJ03132.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ03132.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ03132.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ03132.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796409; CAJ03132.1; -; Genomic_DNA.
DR RefSeq; XP_001681883.1; XM_001681831.1.
DR AlphaFoldDB; Q4QG15; -.
DR STRING; 5664.Q4QG15; -.
DR EnsemblProtists; CAJ03132; CAJ03132; LMJF_13_1390.
DR GeneID; 5650168; -.
DR KEGG; lma:LMJF_13_1390; -.
DR VEuPathDB; TriTrypDB:LmjF.13.1390; -.
DR VEuPathDB; TriTrypDB:LMJFC_130020100; -.
DR VEuPathDB; TriTrypDB:LMJLV39_130018200; -.
DR VEuPathDB; TriTrypDB:LMJSD75_130018200; -.
DR eggNOG; KOG3798; Eukaryota.
DR HOGENOM; CLU_020884_1_1_1; -.
DR InParanoid; Q4QG15; -.
DR OMA; QHWTRRT; -.
DR Proteomes; UP000000542; Chromosome 13.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR PANTHER; PTHR15032; N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D; 1.
DR PANTHER; PTHR15032:SF4; N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D; 1.
DR Pfam; PF12706; Lactamase_B_2; 2.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 121..251
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
FT DOMAIN 291..359
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF12706"
SQ SEQUENCE 401 AA; 45004 MW; 6C037F27D1B11F14 CRC64;
MAESMQSKPS FEYPKRAAIG SYWSNRNRDE KHFKNLGPAS LSSASAGKVM QWMLSHTCNG
VPKPKGGYDA FGKIWYAPCN MAESVAQWRA SMSNDEAQPA KNRVYWIGHS SQLLCLSNGI
NILFDPIFSQ RASPLSFAGP SRRFPPAATA AQLPPIHIVT VSHNHYDHMD KQSIKAVAAR
FPDAHFVVPL KLDRFLREWG VPGASITTLD WYEACEVKGV RVGCTPAQHW GKHSAFDDNE
VLWCGWCVGW QPGQQQQPAS TCEKPTLISF SGIEPSSEAL VEAQRTWNRY KKYFFAGDTA
YNPDVSTSIY AHFGPMDMAA LPIGAYSPRW FMARAHIDPE HAVQIFKDQH IQQAVAVHWG
TFELADEPLD EPPQVLRKTL KDASIDENRF QIIPMGKFIE F
//
