ID Q4QHB0_LEIMA Unreviewed; 1205 AA.
AC Q4QHB0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=CH-like domain-containing protein {ECO:0000259|Pfam:PF06294};
GN ORFNames=LMJF_10_1040 {ECO:0000313|EMBL:CAJ02939.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02939.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02939.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02939.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796406; CAJ02939.1; -; Genomic_DNA.
DR RefSeq; XP_001681438.1; XM_001681386.1.
DR AlphaFoldDB; Q4QHB0; -.
DR EnsemblProtists; CAJ02939; CAJ02939; LMJF_10_1040.
DR GeneID; 5649709; -.
DR KEGG; lma:LMJF_10_1040; -.
DR VEuPathDB; TriTrypDB:LmjF.10.1040; -.
DR VEuPathDB; TriTrypDB:LMJFC_100018200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_100017300; -.
DR VEuPathDB; TriTrypDB:LMJSD75_100017400; -.
DR eggNOG; ENOG502QU8V; Eukaryota.
DR HOGENOM; CLU_270364_0_0_1; -.
DR InParanoid; Q4QHB0; -.
DR OMA; WLRWCLQ; -.
DR Proteomes; UP000000542; Chromosome 10.
DR GO; GO:0005930; C:axoneme; ISO:GeneDB.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; IBA:GO_Central.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR010441; CH_2.
DR InterPro; IPR036872; CH_dom_sf.
DR PANTHER; PTHR12509; SPERMATOGENESIS-ASSOCIATED 4-RELATED; 1.
DR PANTHER; PTHR12509:SF8; SPERMATOGENESIS-ASSOCIATED PROTEIN 4; 1.
DR Pfam; PF06294; CH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 50..143
FT /note="CH-like"
FT /evidence="ECO:0000259|Pfam:PF06294"
FT REGION 244..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 958..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 958..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1205 AA; 125047 MW; 215DAA24641E2E3F CRC64;
MTQASASEVV SVGRRSTAIG KESSLAAPSL SIATTPFSLR TGAALPREIL AWLQSLQLGG
SVKYPKRDLA NGYVIAHICA RYWPHVPLHS FENKAGAASK QSNWFVLQKV LRQKGVDVSA
AMVDGMMNGA DDCASTFLQQ LYTVLTGKHA DTEAVPLEDA LPDVPASKVP VYVPTSTGGA
AARTRHVGGA NGPGLSAKVD SRSDFMGGGN KAASLFGAAA ADVRILDDTS SKDVRNATPV
LLPPLQPSLP MPAHTQPATS PASGLTEEAA AASKPFFNVA VRAAWEVSTV LLTQQASASA
AEDAAGAPIP VQVSSLAGSW FCMKVREAVP VDALEALMEG DEAALAPRPS LSATLRWLSA
VPSGDGGVEG EMKAALWCTG GDGHNVQQAL LRTGAWQAIL GAVPELAQIL VHHGGHGLDA
LVDCLFASVM SAQSRIRGGG EGDAGGGASF AFVRNAVHFS AVLLATLSDL DVYHAIACFE
TYFAASPTFV QALRGLRWSL AADYATVITA VLPANRRLAA TVLSSLWGTI EYAVRDSAAE
ETALYGEAAA GDGESNPMGA EDMAEVCLLV LLRTLLTSLQ PISAGASSRT PLEAPISSHA
QIEASGRAMT SAVRRTAPCS SRNTTITAST SQDAVSNTLV QLAEKRSAAV LQQSVICCAS
ATGVGVDEAL VAVATEKEAA AVALAVQVLR MELHPSLMAA WVAGGRFFDV YNALFPSSDN
AATPTPPNAS SPTLSVLRAR WLRWCLQRRF ELSLSSPSPA TSAAAAMSLS PLAQQRQRVS
HAVAPFGVRD GGGHRATTTT LAQAHDLSAD SAEMRALLTG VQVLCHELSS VAESLKPADA
QSRVLVACAL AESLPFLPAR YKAESTGADG GSAFAEDAAE AAFKVLMHEA TPAQMRSILA
CASELRAGAA VQRGGELEDE AQWMVHRYVG PLKPSGLLVV ESDALLLVKA ALGVLSSGGD
HTGNSGGSRL SPSFSGAGDR DVKLTGGTGG ARRLAARAAV MAREGQVDEK IAERVRWLAS
LLVEGRACVR SGTPPLFPWR STGDSGAVRR SPSSLREDTA TVASAASEAE VLEWQAVLSH
CYEDLVLVIQ AASSRLRQRG GAGAGGNPNA AETHFSEVVG KELLMLAQKA EGVVCSLWRE
LAPILAASAA SRSKSESEQR FIGAATPSVV ANSALISSPP FSFLEDVSHE EVATAVRWIC
AVAGV
//
