ID Q4QHP9_LEIMA Unreviewed; 649 AA.
AC Q4QHP9;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Bromo domain-containing protein {ECO:0000259|PROSITE:PS50014};
GN ORFNames=LMJF_09_1260 {ECO:0000313|EMBL:CAJ02977.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02977.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02977.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02977.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796405; CAJ02977.1; -; Genomic_DNA.
DR RefSeq; XP_001681299.1; XM_001681247.1.
DR AlphaFoldDB; Q4QHP9; -.
DR STRING; 5664.Q4QHP9; -.
DR EnsemblProtists; CAJ02977; CAJ02977; LMJF_09_1260.
DR GeneID; 5649566; -.
DR KEGG; lma:LMJF_09_1260; -.
DR VEuPathDB; TriTrypDB:LmjF.09.1260; -.
DR VEuPathDB; TriTrypDB:LMJFC_090019700; -.
DR VEuPathDB; TriTrypDB:LMJLV39_090019900; -.
DR VEuPathDB; TriTrypDB:LMJSD75_090019500; -.
DR eggNOG; ENOG502QU8D; Eukaryota.
DR HOGENOM; CLU_415943_0_0_1; -.
DR InParanoid; Q4QHP9; -.
DR OMA; VCPRRCD; -.
DR Proteomes; UP000000542; Chromosome 9.
DR GO; GO:0005654; C:nucleoplasm; ISO:GeneDB.
DR CDD; cd04369; Bromodomain; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR PANTHER; PTHR22881; BROMODOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR22881:SF42; LD22651P; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|PROSITE-ProRule:PRU00035};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 178..264
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT REGION 133..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..344
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 649 AA; 69563 MW; 41F40B1E7DE62F67 CRC64;
MSATPKLYNE ADVAALVRSL DRAEDHHIFA VDVLETYPYL AESYTKVCPR RCDLATAAQK
ALEGAYSYDL RLEGLKADIA LMASNCVAYN GPTSAYAETA AKFERYALEQ IDAFVLQHNG
GCRVSRLRLP RASASQEHAS ADGTAPKKGS TGTSAAYKTA AAALPSTREM VQLVDSLNRR
EDGGAFSVDV AEAYPDLRDS YRKICPRPMN LILMHQRAKE GYYTSGSATV YGDTVAASLT
RLREDIELLV RNCITFNVKV QSWVTLARSF QAFAHRRVDD FVLRRATFLR GTAMGADVYE
SKGNASASAP SATASGTAGG DDADRSGQAS PTAAADTVTA TSGGIGGSAV AAGSRKRERA
DERVTASGGR LRAPVPVSRV QVVAEATPQV CPTPLQPSLT IPPLLRRRLT LDHVRHTRLP
LRRVGVSVSR DELYPPAVSP ADVKASSDSS AAAGGAEAAT ASTAMVNIDA SCSASHVLKL
LRESVVKFFA AQRSGTDFVD TFAYSAREEQ LYLSVLAVVA EKYQCTAAHL LLYETESAEL
QEWAALRALD SCRDAGRMAP ASADAGDTIA GDLHYLYFVR FLVQWPQLAS LCCTTATPSS
VPASAAAARG AAQGSLRISR EQLKVVAQVT HITQEFLQFV EAIEERQRQ
//
