ID Q4QHW1_LEIMA Unreviewed; 1161 AA.
AC Q4QHW1;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN ORFNames=LMJF_09_0630 {ECO:0000313|EMBL:CAJ02613.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02613.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02613.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02613.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FR796405; CAJ02613.1; -; Genomic_DNA.
DR RefSeq; XP_001681237.1; XM_001681185.1.
DR AlphaFoldDB; Q4QHW1; -.
DR STRING; 5664.Q4QHW1; -.
DR EnsemblProtists; CAJ02613; CAJ02613; LMJF_09_0630.
DR GeneID; 5649492; -.
DR KEGG; lma:LMJF_09_0630; -.
DR VEuPathDB; TriTrypDB:LmjF.09.0630; -.
DR VEuPathDB; TriTrypDB:LMJFC_090013200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_090012100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_090011800; -.
DR eggNOG; ENOG502QPTM; Eukaryota.
DR HOGENOM; CLU_275269_0_0_1; -.
DR InParanoid; Q4QHW1; -.
DR OMA; PIPAMWE; -.
DR Proteomes; UP000000542; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000542}.
FT DOMAIN 521..620
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 68..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 626..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..750
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 786..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 909..1044
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1137..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..834
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 944..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1016..1042
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1161 AA; 123263 MW; B1206FCA00F74F84 CRC64;
MNSLQTPVAE AAVACLRVLH CLLQDEEVTL AQLSYLIENV HDPLAHVCLP PSQRPTAVPA
LQLSSPSASA LNRYSSPGKH AHSSARSTMA AAAANEVKAR RLPPQPAVVE TAAPAQKEAT
PPKTAKSTER MHQTSKKASR TGEVNATASP SSTSRAEARV PLTLSRYWAI FANLPTLYTV
HLTLVQQLDK VLLRLTQIVD ELHPATQDTE NGGVLHSSAA MPVPDAALNT CKDVSALRNP
SASPAAGARS VYNEIGAMVC EFFGSDLMKH FMAEHMMYTV KYTQQGAPQL LRLSRLWRWC
AEPSGSSGVS AASLTHLSEM DRKMILENDL FLDFLWRSFG PSGIPADDRV CIPASMELKQ
CTAAGGQDQA LSRARALAGG SGVTRRSRST AAASSPAARL PPIPAMWEGF HTLLVLLATP
LSILRRYSHV ARCLVESGAL LPNDRKRLQS CFVNVAALRI SEETNLVMEE LCLHDVRGIM
ALMDIPGAST NSGGAGVEPI NTGAVPALSS TGAPANRSNR VLIHYGRLLK RFERGRHERL
IFLFSDWMCY AQESSNGRFR VRGTIPLAGL RVVEACDNPS MDMVNCFELV APSLSKRITL
YAASPEQRDQ WVDAIRYTVR RFEGQRQRQA ATNGSAHNSN TNMAAGDGGM PSAMRPTAPI
LIPKSRLSRQ RHNDIKWQAY GNLQRRTAEI APQPLHMISG AARVPLPATA GGPVGGSSSF
PVCHSPPPAN VPSGDPSPNN SAVRQRSRST HWHLDYSVKS WSARTSVHRR IRSQELIAVH
QQKLAASSSH IATPTKTDGA PPGGGGATVE SNSNLGPIVV HSLDTGNMDS TSPVREADRN
APLQRQHSRQ ALSPVTSTAA VAASAERRSS SSLHAFTIDI IVSSNRGGGG SGVSTPLRRP
VSERFEAANI SSRGGNTPHQ PPQETFAPPE KVARHPGGRR VASPPSSLES SSSSSSGVLD
NVIGRAGPPA LVTDGVPASG APPSASAGAQ AWSRADSGPP SKSIVSAAEI PPTSPMVVEE
NNSGDSRPIT AGDQSASGTG SVMSAAAPLE ESVDGGAEED DSVTATAVVT AFRTPGVIYH
RLMTPTSPLV MKSRPAAVPR ENSDVPSPFR PIRNSSTGFD ANVRKTTVAA VPLQKTVVPR
HVDPMKKVPH GGNSDDGPVQ P
//
