ID Q4QHY1_LEIMA Unreviewed; 469 AA.
AC Q4QHY1;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN ORFNames=LMJF_09_0430 {ECO:0000313|EMBL:CAJ02511.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02511.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02511.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02511.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796405; CAJ02511.1; -; Genomic_DNA.
DR RefSeq; XP_001681217.1; XM_001681165.1.
DR AlphaFoldDB; Q4QHY1; -.
DR EnsemblProtists; CAJ02511; CAJ02511; LMJF_09_0430.
DR GeneID; 5649472; -.
DR KEGG; lma:LMJF_09_0430; -.
DR VEuPathDB; TriTrypDB:LmjF.09.0430; -.
DR VEuPathDB; TriTrypDB:LMJFC_090011200; -.
DR VEuPathDB; TriTrypDB:LMJLV39_090010100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_090009700; -.
DR eggNOG; ENOG502RYD8; Eukaryota.
DR HOGENOM; CLU_677080_0_0_1; -.
DR InParanoid; Q4QHY1; -.
DR OMA; NHLAQEC; -.
DR Proteomes; UP000000542; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0043067; P:regulation of programmed cell death; IEA:UniProt.
DR Gene3D; 3.90.70.200; Plus-3 domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR004343; Plus-3_dom.
DR InterPro; IPR036128; Plus3-like_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14879; CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR14879:SF19; PROTEIN MDM4; 1.
DR Pfam; PF03126; Plus-3; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00719; Plus3; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF159042; Plus3-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 422..457
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 172..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 51239 MW; A8AB725287CE006E CRC64;
MISEEDSRLF EAAKRAQVSR NTAIHVIENT NSSRILAGAF VRVLLEMPTR NEGYVVARIH
STTAGETYSG FSTNPAQTTN VYLMLELPPP LAAINGVQYQ LNSVSNSSMG EGEFCDWLLM
IRNEPTLRVP TVQGLKEVTA RLHPYEVSRH RSNFHVSANG SMAANGRAGV VDTGGNVPHP
QLAQQQQQQR SLSARGAARQ RRQSLAASSQ TMLIPPMLQD GAPLPDSGDA LLRRSSAAMY
EGGSSGVIAN AESSASAAGS NSNYNVNNRL GRQGTVMTRD YNRNPREDGQ ASHEMSNPEV
PGMSIYTAAP GSQQEQQQRT VLPLSHGGDD GGVAGESDGG PALAATTSFM TRAATDPNME
SEDDEMERRL RQEIMNHLAQ ECVLFPKEAQ GYKLSRLRLL ERDMIEYLQH VRDEIQGKQE
NCIVCMDHVP TVILLPCKHK VMCRLCAPSC PTCPVCRSKI AEMFEPEEI
//
