ID Q4QI50_LEIMA Unreviewed; 1248 AA.
AC Q4QI50;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CAJ02305.1};
GN ORFNames=LMJF_08_1190 {ECO:0000313|EMBL:CAJ02305.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02305.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02305.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02305.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796404; CAJ02305.1; -; Genomic_DNA.
DR RefSeq; XP_001681148.1; XM_001681096.1.
DR AlphaFoldDB; Q4QI50; -.
DR STRING; 5664.Q4QI50; -.
DR EnsemblProtists; CAJ02305; CAJ02305; LMJF_08_1190.
DR GeneID; 5649403; -.
DR KEGG; lma:LMJF_08_1190; -.
DR VEuPathDB; TriTrypDB:LmjF.08.1190; -.
DR VEuPathDB; TriTrypDB:LMJFC_080018600; -.
DR VEuPathDB; TriTrypDB:LMJLV39_080015900; -.
DR VEuPathDB; TriTrypDB:LMJSD75_080016000; -.
DR eggNOG; KOG2041; Eukaryota.
DR HOGENOM; CLU_004048_1_0_1; -.
DR InParanoid; Q4QI50; -.
DR OMA; CVSETHM; -.
DR Proteomes; UP000000542; Chromosome 8.
DR GO; GO:0005930; C:axoneme; IBA:GO_Central.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0030990; C:intraciliary transport particle; ISO:GeneDB.
DR GO; GO:0035721; P:intraciliary retrograde transport; ISO:GeneDB.
DR GO; GO:0042073; P:intraciliary transport; IBA:GO_Central.
DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; ISO:GeneDB.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR15722; IFT140/172-RELATED; 1.
DR PANTHER; PTHR15722:SF8; REPEAT PROTEIN, PUTATIVE-RELATED; 1.
DR PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
SQ SEQUENCE 1248 AA; 139056 MW; EF8B57F9EB978E0E CRC64;
MFVYLSKRIA MPNGVKVSSI AWSEGHGWLA CGGEKGLLKV LKVDGGPQGQ RSGGLSSSQT
LEGHDTTVDL VTWNQQYCKL TSSDVSGRII VWMLHKGMWF EEMVNNRNTS RVVDFAWSPS
GAKICIAYED GAVIVGGVEG NRYWGRELPY KLAKVCWSAD GHSILFGTAT GDVYVHDASS
GAQLSQVEVQ CNDGKASSAL AGLSWHPAWV ERPEPLATLA ICYQSGKMQL MTSIGDETPR
LMDSDFPVHF VSWNPSGTVL AVAALTPATE EDAPTVVTQF FSNEGVHLRT LRVAGKQCGG
ITWEGGGLRV AIAVDSSVYF ANVRPSYKYC YFKKTVVFAC TMPDKVEESV MFWNVNTNER
RTKRVRGLQY LNACKDACVL VSRPDATQQQ RMIQLVNAIG SPLETRFVDM ELYTYDMNSS
VVVCCSDESI YIWQFRDPGT AVDALDPVSM QASRAESQER IIHIGDIVRS DTAPTMKVRS
ALTNDLICAM CVSETHMFVA LESGTLHVYQ LSPLQLVSKY ILPTRAQSMA VNCNSTQLAV
IDLSCTTSVY SMEREKFSLV PCKTEPIDGV EMKDVWNLRW AIDDPHRFAV MEKTRMLVYN
RGVAEEPVQS CANLCKFKSL KIRTLQLDEL LLDPERPRKD YIVDFEAQLL REMRAVLRDG
TAKEAYEFAE SHSTTKLWEL LAEHTLFQLD FTYAEVAFIH CKDYPAIQFV KRVRSLDDPK
KQLAEVNAYY RRFDEAERLY KDVDRKDLAL DLRYRLGDWF GVVRLVQEGG GDEALLLQAW
ENIGDHYASR QKWSKAAQYY TQCRHYRKLA HVFYIIEDYE MLTQLISMAE HDKELMVTLG
NMLLTVGLAE EAAKAFVAAS EPRMAVNGCV QVNMWDRAIA LAEEHRLDDV GQLLEKYAKY
LIQRERLTEA IELYRKAGKH DEAATLLAQL GKRAALSDPL KAKKFYVLSA LEVQKYRTTA
IALNRDGVEV VSEMLNKDRS TVSERTLDAA WRGAEAYHFL LMCQQQIADK NFKAALVLAM
RLMEYDDLVA PVDSYSLIAL TAYLVKNYGL CSKAFARLEQ AERNDEAGGA AAAAATTQLE
NFSLDLDVTQ RTMASACGGS TGGGTSMFTG GGGSALSGTT TSLQLTNPGK GVTRMAPMTY
PTVSLRDPPR PFADLARQIF MTHSPVDTSV DSVPCPTCGS FNKEWAQHCI KCQRPFNTCM
VSGCAIASED GAWQCSVCHR KALEAVVDKY RNCPLCHTPK KGRARRGI
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