ID Q4QIZ0_LEIMA Unreviewed; 438 AA.
AC Q4QIZ0;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Putative arginine N-methyltransferase, type III {ECO:0000313|EMBL:CAJ02133.1};
GN Name=PRMT7 {ECO:0000313|EMBL:CAJ02133.1};
GN ORFNames=LMJF_06_0870 {ECO:0000313|EMBL:CAJ02133.1};
OS Leishmania major.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX NCBI_TaxID=5664 {ECO:0000313|EMBL:CAJ02133.1, ECO:0000313|Proteomes:UP000000542};
RN [1] {ECO:0000313|EMBL:CAJ02133.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=16020728; DOI=10.1126/science.1112680;
RA Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA Ciarloni L., Clayton C., Coulson R.M., Cronin A., Cruz A.K., Davies R.M.,
RA De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA Masuy D., Matthews K., Michaeli S., Mottram J.C., Muller-Auer S.,
RA Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA Rutter S., Saunders D., Schafer M., Schein J., Schwartz D.C., Seeger K.,
RA Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA Barrell B., Myler P.J.;
RT "The genome of the kinetoplastid parasite, Leishmania major.";
RL Science 309:436-442(2005).
RN [2] {ECO:0000313|EMBL:CAJ02133.1, ECO:0000313|Proteomes:UP000000542}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MHOM/IL/81/Friedlin {ECO:0000313|Proteomes:UP000000542};
RX PubMed=22038252; DOI=10.1101/gr.122945.111;
RA Rogers M.B., Hilley J.D., Dickens N.J., Wilkes J., Bates P.A.,
RA Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D.,
RA Sanders M., Seeger K., Dujardin J.C., Berriman M., Smith D.F.,
RA Hertz-Fowler C., Mottram J.C.;
RT "Chromosome and gene copy number variation allow major structural change
RT between species and strains of Leishmania.";
RL Genome Res. 21:2129-2142(2011).
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DR EMBL; FR796402; CAJ02133.1; -; Genomic_DNA.
DR RefSeq; XP_001680858.1; XM_001680806.1.
DR AlphaFoldDB; Q4QIZ0; -.
DR SMR; Q4QIZ0; -.
DR STRING; 5664.Q4QIZ0; -.
DR EnsemblProtists; CAJ02133; CAJ02133; LMJF_06_0870.
DR GeneID; 5649110; -.
DR KEGG; lma:LMJF_06_0870; -.
DR VEuPathDB; TriTrypDB:LmjF.06.0870; -.
DR VEuPathDB; TriTrypDB:LMJFC_060015100; -.
DR VEuPathDB; TriTrypDB:LMJSD75_060015100; -.
DR eggNOG; KOG1501; Eukaryota.
DR HOGENOM; CLU_051104_0_0_1; -.
DR InParanoid; Q4QIZ0; -.
DR OMA; LTYWEAY; -.
DR PHI-base; PHI:11218; -.
DR Proteomes; UP000000542; Chromosome 6.
DR GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR GO; GO:0016273; F:arginine N-methyltransferase activity; ISO:GeneDB.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IMP:GeneDB.
DR GO; GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IBA:GO_Central.
DR GO; GO:0034969; P:histone arginine methylation; ISO:GeneDB.
DR GO; GO:0018216; P:peptidyl-arginine methylation; ISO:GeneDB.
DR GO; GO:0035246; P:peptidyl-arginine N-methylation; IMP:GeneDB.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11006:SF4; PROTEIN ARGININE N-METHYLTRANSFERASE 7; 1.
DR Pfam; PF06325; PrmA; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015};
KW Reference proteome {ECO:0000313|Proteomes:UP000000542};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 48517 MW; 911E8839327741AC CRC64;
MPPKQTSAGG AKKKTSTAAT RNNRHAHPQA DIGFLPPGAK YPAEASWNHH EHQQRNSASY
NKQGDRDRNK DFDYRFEQHI FVPPRLRRVP AALVEAVNDF HYAMMNDLPR NEFYYNMLKK
HIVPGESGVL EIGAGSGLLS MMAAKLNAKW VVAVEGSSEM ASLARSNIAT NRLQDKVKVL
NMLSTELKPC DLPEPPSILV SEIFGTLLLG ESALDYIADA RQRLLPKTAK ILPQHGVQYA
VPIECETLGQ ICAVSSWNGI DLSHVMALQD TTSVVFTKQY GFRMSSVPFR RLADPIPLLT
INFAETKRST FKKVFPVEVP ATASGTAHAW LFYWISTDGE EVMSTAPEDT LHNFSRDMQW
GQALQLIDAG TNSHTPTALS MSAGEFYKFD CALSSDRVVM SLKYTGSSSA AALLKADANE
AEKRRETESE QQWLPPSE
//
