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Database: UniProt
Entry: Q4QQN5
LinkDB: Q4QQN5
Original site: Q4QQN5 
ID   SETD7_XENTR             Reviewed;         366 AA.
AC   Q4QQN5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   16-JAN-2019, entry version 77.
DE   RecName: Full=Histone-lysine N-methyltransferase SETD7;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain-containing protein 7;
GN   Name=setd7;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histone methyltransferase that specifically
CC       monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation
CC       represents a specific tag for epigenetic transcriptional
CC       activation. Plays a central role in the transcriptional activation
CC       of genes. Has also methyltransferase activity toward non-histone
CC       proteins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00910};
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SET7 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00910}.
DR   EMBL; BC098189; AAH98189.1; -; mRNA.
DR   RefSeq; NP_001027510.1; NM_001032339.1.
DR   UniGene; Str.49507; -.
DR   ProteinModelPortal; Q4QQN5; -.
DR   SMR; Q4QQN5; -.
DR   STRING; 8364.ENSXETP00000036910; -.
DR   PaxDb; Q4QQN5; -.
DR   Ensembl; ENSXETT00000036910; ENSXETP00000036910; ENSXETG00000016939.
DR   GeneID; 613102; -.
DR   KEGG; xtr:613102; -.
DR   CTD; 80854; -.
DR   Xenbase; XB-GENE-949196; setd7.
DR   eggNOG; KOG1079; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   GeneTree; ENSGT00390000004827; -.
DR   HOGENOM; HOG000074731; -.
DR   HOVERGEN; HBG028309; -.
DR   InParanoid; Q4QQN5; -.
DR   KO; K11431; -.
DR   OMA; SSVYHFD; -.
DR   OrthoDB; 675418at2759; -.
DR   TreeFam; TF106392; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000016939; Expressed in 12 organ(s), highest expression level in skeletal muscle tissue.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0016279; F:protein-lysine N-methyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0018027; P:peptidyl-lysine dimethylation; ISS:UniProtKB.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR017155; Hist-Lys_N-MeTrfase_SET.
DR   InterPro; IPR003409; MORN.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF02493; MORN; 3.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF037249; Histone_Lys_mtfrase_SET; 1.
DR   PROSITE; PS51577; SAM_MT43_SET7; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Activator; Chromatin regulator; Chromosome; Complete proteome;
KW   Methyltransferase; Nucleus; Reference proteome; Repeat;
KW   S-adenosyl-L-methionine; Transcription; Transcription regulation;
KW   Transferase.
FT   CHAIN         1    366       Histone-lysine N-methyltransferase SETD7.
FT                                /FTId=PRO_0000316991.
FT   REPEAT       36     58       MORN 1.
FT   REPEAT       59     81       MORN 2.
FT   REPEAT      106    128       MORN 3.
FT   DOMAIN      214    336       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   REGION      226    228       S-adenosyl-L-methionine binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00910}.
FT   REGION      294    297       S-adenosyl-L-methionine binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00910}.
SQ   SEQUENCE   366 AA;  40816 MW;  9470B465CFFD2F4B CRC64;
     MDSEDETVEE TVEGLLDDDG LPHGFCTVNY SSTDRFEGHF VHGEKNGRGK FYFFDGSTLE
     GFYVDDALQG QGIYTYEDGG SLHGTYVEGE LNGPAQEYDT DGRLIFKGQY KDNVRHGVCW
     IYYPDGGSLV GEVNEDGDMT GDKVAYVYPD GRMALYGKFI DAEMLEGKLA ILTSVDEGKP
     HFELVPNGPV YNFDKSTPSC ISVNPLFPDP YESERVYVND SLIHNAGEGL FAKVASAAQT
     VMSFYNGVRI THQEVDSREW ALNGNTISLD DETVLDVPAP YNSYYKYCAS LGHKANHSFS
     PNCMYDTFVH PRFGPIKCIR TMKAVEKDEE LTVAYGYDHS VTGKNGPEAP EWYQQQLTAF
     QATQQK
//
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