ID Q4QR57_XENLA Unreviewed; 454 AA.
AC Q4QR57;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 89.
DE SubName: Full=Keratin, type I cytoskeletal 47 kDa {ECO:0000313|RefSeq:NP_001082432.1};
DE SubName: Full=LOC398464 protein {ECO:0000313|EMBL:AAH97543.1};
GN Name=krt12.5.S {ECO:0000313|RefSeq:NP_001082432.1,
GN ECO:0000313|Xenbase:XB-GENE-1219328};
GN Synonyms=krt12 {ECO:0000313|RefSeq:NP_001082432.1,
GN ECO:0000313|Xenbase:XB-GENE-1219328}, krt12.1
GN {ECO:0000313|RefSeq:NP_001082432.1}, krt12.5
GN {ECO:0000313|Xenbase:XB-GENE-1219328}, krt12.L
GN {ECO:0000313|RefSeq:NP_001082432.1}, krt12.S
GN {ECO:0000313|RefSeq:NP_001082432.1}, LOC398464
GN {ECO:0000313|EMBL:AAH97543.1}, xk81b2
GN {ECO:0000313|RefSeq:NP_001082432.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH97543.1};
RN [1] {ECO:0000313|RefSeq:NP_001082432.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=2430981; DOI=10.1083/jcb.103.5.1957;
RA Miyatani S., Winkles J.A., Sargent T.D., Dawid I.B.;
RT "Stage-specific keratins in Xenopus laevis embryos and tadpoles: the XK81
RT gene family.";
RL J. Cell Biol. 103:1957-1965(1986).
RN [2] {ECO:0000313|RefSeq:NP_001082432.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [3] {ECO:0000313|EMBL:AAH97543.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH97543.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001082432.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; BC097543; AAH97543.1; -; mRNA.
DR RefSeq; NP_001082432.1; NM_001088963.1.
DR STRING; 8355.Q4QR57; -.
DR PaxDb; 8355-Q4QR57; -.
DR DNASU; 398464; -.
DR GeneID; 398464; -.
DR KEGG; xla:398464; -.
DR AGR; Xenbase:XB-GENE-1219328; -.
DR CTD; 398464; -.
DR Xenbase; XB-GENE-1219328; krt12.5.S.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 398464; Expressed in neurula embryo and 16 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF369; KERATIN, TYPE I CYTOSKELETAL 12; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698}.
FT DOMAIN 82..397
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 405..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..120
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 196..223
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 295..382
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 405..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 454 AA; 49481 MW; 238685B55E34DCD3 CRC64;
MSFRSSSSYS LQSKGISGGG GYGAGFGGGS GAGFGGGSGA GFGGGYGAGF GGGASSGFSL
SSAGGFGAAA ASSSFSNFGG NDKQTMQNLN DRLASYLEKV RALEAANADL ELKIREWYEK
QKGSGIGAGS KDFSKYFEII SDLRNKILSA TIDNSRVVLQ IDNAKLAADD FRLKFENELA
LRQSVETDIN GLRRVLDELT LARGDLEMQI ESLTEELAYL KKNHEEEMSI AKSSSAGQVN
VEMDAAPGID LNKILSDMRA DYETLAEKNR RDAELWFNQK SGELKKEIQT GVEQVQTSKS
EINDLRRSLQ SLEIELQSQL AMKKSLEDTL AETDGRYGAQ LQTIQFSIRS LEEQLLQIRS
DMERQNMEYR QLLDIKTRLE MEIETYRRLL EGEFGSSSSL KSSIVQATEV STSQSSSSSK
KDPSKTRKVK TIVEEVVDGK VVSSRVEEIE ESVK
//
