ID MIER3_MACFA Reviewed; 550 AA.
AC Q4R3R9; Q4R718;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 84.
DE RecName: Full=Mesoderm induction early response protein 3;
DE Short=Mi-er3;
GN Name=MIER3; ORFNames=QtsA-14674, QtsA-16550;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcriptional repressor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC ECO:0000255|PROSITE-ProRule:PRU00624}.
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DR EMBL; AB169011; BAE01106.1; -; mRNA.
DR EMBL; AB179196; BAE02247.1; -; mRNA.
DR RefSeq; XP_005556987.1; XM_005556930.2.
DR AlphaFoldDB; Q4R3R9; -.
DR STRING; 9541.ENSMFAP00000000077; -.
DR GeneID; 101925174; -.
DR KEGG; mcf:101925174; -.
DR CTD; 166968; -.
DR VEuPathDB; HostDB:ENSMFAG00000042794; -.
DR eggNOG; KOG4329; Eukaryota.
DR OMA; PMNICSE; -.
DR OrthoDB; 3059114at2759; -.
DR Proteomes; UP000233100; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd11661; SANT_MTA3_like; 1.
DR Gene3D; 4.10.1240.50; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR040138; MIER/MTA.
DR InterPro; IPR045787; MIER1/3_C.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR10865:SF22; MESODERM INDUCTION EARLY RESPONSE PROTEIN 3; 1.
DR PANTHER; PTHR10865; METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF19426; MIER1_3_C; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..550
FT /note="Mesoderm induction early response protein 3"
FT /id="PRO_0000313681"
FT DOMAIN 174..272
FT /note="ELM2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT DOMAIN 277..329
FT /note="SANT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z3K6"
FT MOD_RES 53
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z3K6"
FT MOD_RES 114
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UHF3"
FT MOD_RES 156
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q7Z3K6"
FT MOD_RES 163
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q3UHF3"
FT MOD_RES 165
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UHF3"
FT MOD_RES 168
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q3UHF3"
FT CONFLICT 412
FT /note="D -> V (in Ref. 1; BAE01106)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 550 AA; 61396 MW; EEDBD6E86BFEDEA3 CRC64;
MAEASFGSSS PVGSLSSEDH DFDPTAEMLV HDYDDERTLE EEEMMDEGKN FSSEIEDLEK
EGTMPLEDLL AFYGYEPTIP AVANSSANSS PSELADELPD MTLDKEEIAK DLLSGDDEET
QSSADDLTPS VTSHETSDFF PRPLRSNTTC DGDKESEVED VETDSGNSPE DLRKEIMIGL
QYQAEIPPYL GEYAGNEKVY ENEDQLLWCP DVVLESKVKE YLVETSLRTG NEKIMDRISA
GTHTRDNEQA LYELLKCNHN IKEAIERYCC NGKASQEGMT AWTEEECRSF EHALMLFGKD
FHLIQKNKVR TRTVAECVAF YYMWKKSERY DYFAQQTRFG KKRYNHHPGV TDYMDRLVDE
TEALGGTVNA SALTSNRPEP IPDQQLNILN SFTASDLTAL TNSVATVCDP TDVNCLDDSF
PPLGSTPRGQ VNHVPVVTEE LLTLPSNGES DCFNLFETGF YHSELNPMNM CSEESERPAK
RLKMGIAVPE SFMNEVSVNN LGVDFENHTH HITSAKMAVS VADFGSLSAS ETNGFISAHA
LHQHAALHSE
//
