ID Q4R4F9_MESAU Unreviewed; 840 AA.
AC Q4R4F9;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Signal transducer and activator of transcription {ECO:0000256|RuleBase:RU046415};
GN Name=STAT2 {ECO:0000313|EMBL:BAE00060.1};
GN Synonyms=Stat2 {ECO:0000313|RefSeq:NP_001268551.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|EMBL:BAE00060.1};
RN [1] {ECO:0000313|EMBL:BAE00060.1, ECO:0000313|RefSeq:NP_001268551.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15956600; DOI=10.1128/JVI.79.13.8591-8601.2005;
RA Nishio M., Tsurudome M., Ito M., Garcin D., Kolakofsky D., Ito Y.;
RT "Identification of paramyxovirus V protein residues essential for STAT
RT protein degradation and promotion of virus replication.";
RL J. Virol. 79:8591-8601(2005).
RN [2] {ECO:0000313|RefSeq:NP_001268551.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [3] {ECO:0000313|RefSeq:NP_001268551.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU046415}. Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU046415}.
CC -!- SIMILARITY: Belongs to the transcription factor STAT family.
CC {ECO:0000256|ARBA:ARBA00005586, ECO:0000256|RuleBase:RU046415}.
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DR EMBL; AB177399; BAE00060.1; -; mRNA.
DR RefSeq; NP_001268551.1; NM_001281622.1.
DR GeneID; 101830537; -.
DR KEGG; maua:101830537; -.
DR CTD; 6773; -.
DR eggNOG; KOG3667; Eukaryota.
DR OrthoDB; 7823at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0010033; P:response to organic substance; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd10373; SH2_STAT2; 1.
DR CDD; cd16846; STAT2_DBD; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.20; STAT transcription factor, all-alpha domain; 1.
DR Gene3D; 2.60.40.630; STAT transcription factor, DNA-binding domain; 1.
DR Gene3D; 1.10.532.10; STAT transcription factor, N-terminal domain; 1.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR001217; STAT.
DR InterPro; IPR022756; STAT2_C.
DR InterPro; IPR035854; STAT2_SH2.
DR InterPro; IPR048988; STAT_linker.
DR InterPro; IPR036535; STAT_N_sf.
DR InterPro; IPR013800; STAT_TF_alpha.
DR InterPro; IPR015988; STAT_TF_coiled-coil.
DR InterPro; IPR013801; STAT_TF_DNA-bd.
DR InterPro; IPR012345; STAT_TF_DNA-bd_N.
DR InterPro; IPR013799; STAT_TF_prot_interaction.
DR PANTHER; PTHR11801; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION; 1.
DR PANTHER; PTHR11801:SF41; SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12188; STAT2_C; 1.
DR Pfam; PF01017; STAT_alpha; 1.
DR Pfam; PF02864; STAT_bind; 1.
DR Pfam; PF02865; STAT_int; 1.
DR Pfam; PF21354; STAT_linker; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00964; STAT_int; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF47655; STAT; 1.
DR SUPFAM; SSF48092; Transcription factor STAT-4 N-domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|RuleBase:RU046415};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU046415};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU046415};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU046415};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU046415};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU046415};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU046415}.
FT DOMAIN 572..710
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
SQ SEQUENCE 840 AA; 96437 MW; 907409CCE49AC59F CRC64;
MAQWETLQNL DSPFLDQLHQ LYSQSTLPMD VRQHLAAWIE DQNWREAVLG NDQSKANMLY
FTILDQLNQW DHCSDPDCFL LQHNLRKFSR DIQTFPNGPT QLAEMIFNLL LEEKRILNQA
QRSQEVQASP APEAAVGSQQ LEIESRVLDL QATVEVLVRS VRQLKDLHDV FSFRYTVLTQ
KKKTPSLDPH QNQELQMVQA TANELDRMRK EVLDMSRAQV GRLTTLVDLL LPKLDEWRVQ
QQRSCIGAPP PELQLEQLEQ WLTAGAKLLF HLRQLLKQLK EMSHMLKYDG DMFSKGVDLQ
NAQVTELLQR LLQRSFVVET QPCMPQTLHR PLILKTGSKF TVRTRLLVRL QEGNESLKAE
VSIDRNSELP PGFRKFNILT SNQKTLTPEE GQRQGLVWDF GFLTLVEQRS VGTGKGTNKG
PLAVTEELHV VSFVVQYVYQ GLKMELQTDT LPVVIISNMN QLSIAWASVL WFNMLSPTPQ
DPRFFCHAPK APWSLLGPVL SWQFSSYVGR GLSSEQLGML KNKLFGKNCK MEDALLSWVD
FSKRDSPPGK IPFWTWLDKI LELVHDHLKD LWNDGHIMGF VSRNQERRLL KKTVSGTFLL
RFSETSEGGI TCSWVEHQDD DKVVIYSVQP YTKEVLQSLP LTEIIRHYQV LAEENIPENP
LRFLYPRIPR DEAFGCYYQE KVNFEERRKY LKHRLIVVSN RQVDELQQPL GLEQEPELDS
LDLNAELTSA TTLEQDLELQ MLLKEGLDLG AELELNPTLC VASQTVLRAD PGPVSQPSPD
SDLPHDLQQL NMDIFRNNIN IDDIMPYGDP LLADQNIVDE AYMSCQSHFD VDGPLIPSDD
//
