ID Q4SGS9_TETNG Unreviewed; 826 AA.
AC Q4SGS9;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=(spotted green pufferfish) hypothetical protein {ECO:0000313|EMBL:CAG00153.1};
DE SubName: Full=Solute carrier family 22 member 2 {ECO:0000313|Ensembl:ENSTNIP00000012615.1};
GN ORFNames=GSTENG00018493001 {ECO:0000313|EMBL:CAG00153.1};
OS Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS nigroviridis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX NCBI_TaxID=99883 {ECO:0000313|EMBL:CAG00153.1};
RN [1] {ECO:0000313|EMBL:CAG00153.1, ECO:0000313|Proteomes:UP000007303}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15496914; DOI=10.1038/nature03025;
RA Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT early vertebrate proto-karyotype.";
RL Nature 431:946-957(2004).
RN [2] {ECO:0000313|EMBL:CAG00153.1}
RP NUCLEOTIDE SEQUENCE.
RG Genoscope;
RG Whitehead Institute Centre for Genome Research;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSTNIP00000012615.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=prostaglandin E2(out) = prostaglandin E2(in);
CC Xref=Rhea:RHEA:50984, ChEBI:CHEBI:606564;
CC Evidence={ECO:0000256|ARBA:ARBA00036345};
CC -!- SUBCELLULAR LOCATION: Basal cell membrane
CC {ECO:0000256|ARBA:ARBA00034696}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034696}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CAAE01014590; CAG00153.1; -; Genomic_DNA.
DR STRING; 99883.ENSTNIP00000012615; -.
DR Ensembl; ENSTNIT00000012806.1; ENSTNIP00000012615.1; ENSTNIG00000009731.1.
DR KEGG; tng:GSTEN00018493G001; -.
DR GeneTree; ENSGT00940000155089; -.
DR HOGENOM; CLU_381113_0_0_1; -.
DR TreeFam; TF315847; -.
DR Proteomes; UP000007303; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 3.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR24064; SOLUTE CARRIER FAMILY 22 MEMBER; 1.
DR PANTHER; PTHR24064:SF291; SOLUTE CARRIER FAMILY 22 MEMBER 1; 1.
DR Pfam; PF00083; Sugar_tr; 3.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..41
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 198..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 335..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 615..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 698..720
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 726..747
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 754..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 786..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 826 AA; 92375 MW; 720B7CB6F76364C8 CRC64;
MATFDDVLEE AGAFGRCQKR IFALLCLLTL TSSGFFAGIV FQGYTPDHWC RDSAVVDMRR
ACGWSLEHTR SLTVPLSNTS GRLQPSKCTR FDVDWNTTTL GCDTETLNLT GVPLSACKEG
WEFDYEGRRT FVTEVRGEGH QLVVALAEKR FEPLLLSQFN LVCSDSWLVD MFQSIFGVGR
LVGSLTVGYF ADMYGRKVSV IMTTLLNCMA GISMAVVPSY IYILILRAVI GFGAKGSSTS
CYVLESPRWL VSQKKFSKAY EITNAMATEN KRNISKNLEA LVEDEGDSPS GSILDLFRTP
NMRKYTLILM FNWFTSEVVY QGLIMRVGIT AKNLYIDFLI SALVEIPAAL LILFTIERMG
RRLPFASSNF IAGLSCLITA FIPDRVISLM GGALVLLLPE TKGVPLPDTI DDVEFPDRRA
CGWSLEHTRS LTVPLSNTSG RLQPSKCTRF DVDWNTTTLG CDTETLNLTG VPLSACKEGW
EFDYEGRRTF VTEFNLVCSD SWLVDMFQSV IGVGYLVGSL TVGYFSDIVR HICSFSYGRK
VSIIMSTLLN CMAGISMAVA PSYICILILR AIVGFVTEIV GVEQRRFVGI FYQMFISISF
LIIPLLAYFI TDWRWLQAAF CLPSIIFVCY YWFIPESPRW LVSQKKFSKA YEITNAMATE
NKRNISKNLE ALAEDEGDSP SGSILDLFRT PNMRKYTLIL MFNWFTSEVV YQGLIMRVGI
TAKNLYIDFF ISALVEIPAA LLILFTIERM GRRLPFASSN FIAGLSCLIT AFIPDSMHWA
KTVVGSIGRL GVVMAVEMVI FVNVELYPTF VRSHLTHGRN FSAAAA
//
