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Database: UniProt
Entry: Q4SN97_TETNG
LinkDB: Q4SN97_TETNG
Original site: Q4SN97_TETNG 
ID   Q4SN97_TETNG            Unreviewed;       535 AA.
AC   Q4SN97;
DT   19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT   19-JUL-2005, sequence version 1.
DT   16-OCT-2019, entry version 102.
DE   SubName: Full=Chromosome 8 SCAF14543, whole genome shotgun sequence {ECO:0000313|EMBL:CAF97885.1};
DE   SubName: Full=Potassium inwardly-rectifying channel, subfamily J, member 14 {ECO:0000313|Ensembl:ENSTNIP00000010899};
GN   ORFNames=GSTENG00015383001 {ECO:0000313|EMBL:CAF97885.1};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae;
OC   Tetraodon.
OX   NCBI_TaxID=99883 {ECO:0000313|EMBL:CAF97885.1};
RN   [1] {ECO:0000313|EMBL:CAF97885.1, ECO:0000313|Ensembl:ENSTNIP00000010899}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A.,
RA   Nicaud S., Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B.,
RA   Dasilva C., Salanoubat M., Levy M., Boudet N., Castellano S.,
RA   Anthouard V., Jubin C., Castelli V., Katinka M., Vacherie B.,
RA   Biemont C., Skalli Z., Cattolico L., Poulain J., De Berardinis V.,
RA   Cruaud C., Duprat S., Brottier P., Coutanceau J.-P., Gouzy J.,
RA   Parra G., Lardier G., Chapple C., McKernan K.J., McEwan P., Bosak S.,
RA   Kellis M., Volff J.-N., Guigo R., Zody M.C., Mesirov J.,
RA   Lindblad-Toh K., Birren B., Nusbaum C., Kahn D., Robinson-Rechavi M.,
RA   Laudet V., Schachter V., Quetier F., Saurin W., Scarpelli C.,
RA   Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals
RT   the early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
RN   [2] {ECO:0000313|EMBL:CAF97885.1}
RP   NUCLEOTIDE SEQUENCE.
RG   Genoscope;
RG   Whitehead Institute Centre for Genome Research;
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSTNIP00000010899}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; CAAE01014543; CAF97885.1; -; Genomic_DNA.
DR   Ensembl; ENSTNIT00000011081; ENSTNIP00000010899; ENSTNIG00000008074.
DR   KEGG; tng:GSTEN00015383G001; -.
DR   eggNOG; KOG3827; Eukaryota.
DR   eggNOG; ENOG410XQ62; LUCA.
DR   GeneTree; ENSGT00960000186595; -.
DR   HOGENOM; HOG000082521; -.
DR   KO; K05007; -.
DR   OMA; QHGSQYE; -.
DR   TreeFam; TF313676; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007303};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007303};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM    174    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    271    296       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      139    301       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      308    462       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       34     55       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION       76    137       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      209    231       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    110    125       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   SITE        287    287       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   535 AA;  58926 MW;  313CD229D484832D CRC64;
     MGAARVKRRF SAVVDGPVEE EEVMRLALSD ADTAMVGGGP ASSPSSPPPT HALNGKLVPF
     QDIAVTARRQ SVIGESVRGD AGEGGMRARG MCSGIVKGSG KGGRVKGRSP SDQDSLSSPS
     TTSRRCTRRS SRRPRQRFVG KDGRCNVTFV NMSERGQRYL SDLFTTCVDI RWRWMLIIFT
     LSFLLSWLLF GFAFWLIASA HGDLSIGLPP GSGSSPGPGG TGSGGGSEKE ETVGEPCFLQ
     VNSFMAAFLF SLETQTSIGY GFRSVTEECP LAVVAVVLQC IVGCIIDAFI IGAVMAKIAK
     PKKRNETLVF SDTAVVALRD GKLCMMWRVG NMRKSHLVEA HVRAQLLKPR VTEEGEFLPL
     DNVDINVGFD TGTDRIFLVS PVTIVHEIND ESPFFEIDRK TLEKDNDLEL VVILEGMVEA
     TAMTTQCRSS YVASEILWGH RFEPVLFERK ECYQVRKAEI GTCSRWTTRF SIGHMKSQTH
     HHAVLKSLQS RKAFKAHAHL SAMKMKWLCS SRHRIMNLIK PKTLTVPRHQ QEDSP
//
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