ID Q4U0Y7_9ACTN Unreviewed; 408 AA.
AC Q4U0Y7;
DT 19-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 19-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=3-ketoacyl ACP synthase beta {ECO:0000313|EMBL:AJE43678.1};
DE SubName: Full=Act minimal PKS chain-length factor (CLF/KS beta) {ECO:0000313|EMBL:MBB4795183.1};
DE EC=2.3.1.- {ECO:0000313|EMBL:MBB4795183.1};
DE SubName: Full=Ketosynthase chain-length factor {ECO:0000313|EMBL:QEV42184.1};
DE SubName: Full=Type II PKS CLF domain {ECO:0000313|EMBL:AAY57525.1};
GN ORFNames=BJY54_005795 {ECO:0000313|EMBL:MBB4795183.1}, CP978_29745
GN {ECO:0000313|EMBL:QEV42184.1}, SNOD_29440
GN {ECO:0000313|EMBL:AJE43678.1};
OS Streptomyces nodosus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=40318 {ECO:0000313|EMBL:AAY57525.1};
RN [1] {ECO:0000313|EMBL:AAY57525.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16832727; DOI=10.1007/s00284-005-0050-x;
RA Chuck J.A., Dunn C., Facultad F.E., Nakazono C., Nikodinovic J.,
RA Barrow K.D.;
RT "Amplification of DNA encoding entire type I polyketide synthase domains
RT and linkers from streptomyces species.";
RL Curr. Microbiol. 53:89-94(2006).
RN [2] {ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|Proteomes:UP000031526};
RA Sweeney P., Stephens N., Murphy C., Caffrey P.;
RT "Sequence of the Streptomyces nodosus genome.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AJE43678.1, ECO:0000313|Proteomes:UP000031526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:AJE43678.1,
RC ECO:0000313|Proteomes:UP000031526};
RX PubMed=26497174;
RA Sweeney P., Murphy C.D., Caffrey P.;
RT "Exploiting the genome sequence of Streptomyces nodosus for enhanced
RT antibiotic production.";
RL Appl. Microbiol. Biotechnol. 100:1285-1295(2016).
RN [4] {ECO:0000313|EMBL:QEV42184.1, ECO:0000313|Proteomes:UP000325763}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 14899 {ECO:0000313|EMBL:QEV42184.1,
RC ECO:0000313|Proteomes:UP000325763};
RA Lee N., Cho B.-K.;
RT "Streptomyces genome completion.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:MBB4795183.1, ECO:0000313|Proteomes:UP000544950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40109 {ECO:0000313|EMBL:MBB4795183.1,
RC ECO:0000313|Proteomes:UP000544950};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; DQ020254; AAY57525.1; -; Genomic_DNA.
DR EMBL; CP009313; AJE43678.1; -; Genomic_DNA.
DR EMBL; JACHMR010000001; MBB4795183.1; -; Genomic_DNA.
DR EMBL; CP023747; QEV42184.1; -; Genomic_DNA.
DR RefSeq; WP_043445955.1; NZ_JACHMR010000001.1.
DR STRING; 40318.SNOD_29440; -.
DR KEGG; snq:CP978_29745; -.
DR HOGENOM; CLU_000022_69_2_11; -.
DR OrthoDB; 416758at2; -.
DR Proteomes; UP000031526; Chromosome.
DR Proteomes; UP000325763; Chromosome.
DR Proteomes; UP000544950; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR CDD; cd00832; CLF; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF322; POLYKETIDE BETA-KETOACYL SYNTHASE 2-RELATED; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:MBB4795183.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031526};
KW Transferase {ECO:0000256|RuleBase:RU003694, ECO:0000313|EMBL:MBB4795183.1}.
FT DOMAIN 5..406
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 408 AA; 42438 MW; F1C6E881C98565D2 CRC64;
MNGSGVRVAV TGLGVVAPNG LGAEAYWTAT RKGTSGIGRI SRFVPDGYPA QLAGEIEGFA
AAEYLPGRLL PQTDRMTQLA LVAADWAFED AAVRPGELPE FEMGVITASS SGGFEFGQRE
LQALWSQGSR YVSAYQSFAW FYAVNSGQIS IRNGMRGPSG VVVSDQAGGL DAVAQARRQI
RKGTRLVMSG AVDASICPWG WVAQMASNRL STRTDPERAY LPFDAAANGH VAGEGGALLV
LEELEQARAR GAKQIYGEIA GYGSTLDPRP GSERPAGLRK AIELALADAG ATPGEIDVVF
ADAAAIPELD RIEAAAINEV FGAGAVPVTA PKTMTGRLYS GAAPLDLAAA FLAMRDGVIP
PSIGVTPSPE HGLDLVVDQE RTATVRSALV IARGHGGFNS AIVVRSAA
//
