ID Q4UCV7_THEAN Unreviewed; 71 AA.
AC Q4UCV7;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 66.
DE RecName: Full=General transcription and DNA repair factor IIH subunit TFB5 {ECO:0000256|RuleBase:RU368032};
GN ORFNames=TA04975 {ECO:0000313|EMBL:CAI75344.1}, TAT_000226400
GN {ECO:0000313|EMBL:SVP93275.1}, TAV_000226500
GN {ECO:0000313|EMBL:SVP92471.1};
OS Theileria annulata.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Theileriidae; Theileria.
OX NCBI_TaxID=5874 {ECO:0000313|EMBL:CAI75344.1, ECO:0000313|Proteomes:UP000001950};
RN [1] {ECO:0000313|EMBL:CAI75344.1, ECO:0000313|Proteomes:UP000001950}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ankara {ECO:0000313|Proteomes:UP000001950}, and Ankara isolate
RC clone C9 {ECO:0000313|EMBL:CAI75344.1};
RX PubMed=15994557; DOI=10.1126/science.1110418;
RA Pain A., Renauld H., Berriman M., Murphy L., Yeats C.A., Weir W.,
RA Kerhornou A., Aslett M., Bishop R., Bouchier C., Cochet M., Coulson R.M.R.,
RA Cronin A., de Villiers E.P., Fraser A., Fosker N., Gardner M., Goble A.,
RA Griffiths-Jones S., Harris D.E., Katzer F., Larke N., Lord A., Maser P.,
RA McKellar S., Mooney P., Morton F., Nene V., O'Neil S., Price C.,
RA Quail M.A., Rabbinowitsch E., Rawlings N.D., Rutter S., Saunders D.,
RA Seeger K., Shah T., Squares R., Squares S., Tivey A., Walker A.R.,
RA Woodward J., Dobbelaere D.A.E., Langsley G., Rajandream M.A., McKeever D.,
RA Shiels B., Tait A., Barrell B.G., Hall N.;
RT "Genome of the host-cell transforming parasite Theileria annulata compared
RT with T. parva.";
RL Science 309:131-133(2005).
RN [2] {ECO:0000313|EMBL:SVP92471.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Anand {ECO:0000313|EMBL:SVP92471.1};
RA Quirk P.G., Krulwich T.A.;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In NER, TFIIH acts by opening DNA around the lesion to allow
CC the excision of the damaged oligonucleotide and its replacement by a
CC new DNA fragment. In transcription, TFIIH has an essential role in
CC transcription initiation. When the pre-initiation complex (PIC) has
CC been established, TFIIH is required for promoter opening and promoter
CC escape. {ECO:0000256|RuleBase:RU368032}.
CC -!- SUBUNIT: Component of the 7-subunit TFIIH core complex.
CC {ECO:0000256|RuleBase:RU368032}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU368032}.
CC -!- SIMILARITY: Belongs to the TFB5 family.
CC {ECO:0000256|RuleBase:RU368032}.
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DR EMBL; CR940352; CAI75344.1; -; Genomic_DNA.
DR EMBL; UIVS01000003; SVP92471.1; -; Genomic_DNA.
DR EMBL; UIVT01000003; SVP93275.1; -; Genomic_DNA.
DR RefSeq; XP_954820.1; XM_949727.1.
DR AlphaFoldDB; Q4UCV7; -.
DR STRING; 5874.Q4UCV7; -.
DR GeneID; 3864697; -.
DR KEGG; tan:TA04975; -.
DR VEuPathDB; PiroplasmaDB:TA04975; -.
DR eggNOG; ENOG502R0K1; Eukaryota.
DR InParanoid; Q4UCV7; -.
DR OMA; LEIAECY; -.
DR OrthoDB; 419at2759; -.
DR Proteomes; UP000001950; Chromosome 3.
DR GO; GO:0000439; C:transcription factor TFIIH core complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005675; C:transcription factor TFIIH holo complex; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.70.1220; TFB5-like; 1.
DR InterPro; IPR035935; TFB5-like_sf.
DR InterPro; IPR009400; TFIIH_TTDA/Tfb5.
DR Pfam; PF06331; Tfb5; 1.
DR SMART; SM01395; Tbf5; 1.
DR SUPFAM; SSF142897; TFB5-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU368032};
KW DNA repair {ECO:0000256|RuleBase:RU368032};
KW Nucleus {ECO:0000256|RuleBase:RU368032};
KW Reference proteome {ECO:0000313|Proteomes:UP000001950};
KW Transcription {ECO:0000256|RuleBase:RU368032};
KW Transcription regulation {ECO:0000256|RuleBase:RU368032}.
SQ SEQUENCE 71 AA; 8091 MW; 4D180F1C4690B671 CRC64;
MVSALTGTLL KCDPPTMEIV KQINESKHFI IEQIDEGVAL CKDSVTQFLK EEVTRRLEIA
ECYIPPNEQQ K
//