ID DBH_RICFE Reviewed; 99 AA.
AC Q4UKH2;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 24-JAN-2024, entry version 80.
DE RecName: Full=DNA-binding protein HU;
GN Name=hup; Synonyms=hupA; OrderedLocusNames=RF_1108;
OS Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) (Rickettsia azadi).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX NCBI_TaxID=315456;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-1525 / URRWXCal2;
RX PubMed=15984913; DOI=10.1371/journal.pbio.0030248;
RA Ogata H., Renesto P., Audic S., Robert C., Blanc G., Fournier P.-E.,
RA Parinello H., Claverie J.-M., Raoult D.;
RT "The genome sequence of Rickettsia felis identifies the first putative
RT conjugative plasmid in an obligate intracellular parasite.";
RL PLoS Biol. 3:1-12(2005).
CC -!- FUNCTION: Histone-like DNA-binding protein which is capable of wrapping
CC DNA to stabilize it, and thus to prevent its denaturation under extreme
CC environmental conditions. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the bacterial histone-like protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAY61959.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000053; AAY61959.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q4UKH2; -.
DR SMR; Q4UKH2; -.
DR STRING; 315456.RF_1108; -.
DR KEGG; rfe:RF_1108; -.
DR eggNOG; COG0776; Bacteria.
DR HOGENOM; CLU_105066_3_2_5; -.
DR Proteomes; UP000008548; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd13831; HU; 1.
DR Gene3D; 4.10.520.10; IHF-like DNA-binding proteins; 1.
DR InterPro; IPR000119; Hist_DNA-bd.
DR InterPro; IPR020816; Histone-like_DNA-bd_CS.
DR InterPro; IPR010992; IHF-like_DNA-bd_dom_sf.
DR PANTHER; PTHR33175; DNA-BINDING PROTEIN HU; 1.
DR PANTHER; PTHR33175:SF3; DNA-BINDING PROTEIN HU-BETA; 1.
DR Pfam; PF00216; Bac_DNA_binding; 1.
DR PRINTS; PR01727; DNABINDINGHU.
DR SMART; SM00411; BHL; 1.
DR SUPFAM; SSF47729; IHF-like DNA-binding proteins; 1.
DR PROSITE; PS00045; HISTONE_LIKE; 1.
PE 3: Inferred from homology;
KW DNA condensation; DNA-binding.
FT CHAIN 1..99
FT /note="DNA-binding protein HU"
FT /id="PRO_0000273733"
FT REGION 67..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 99 AA; 11150 MW; B11CE5535C86D36E CRC64;
MNKTEFIAFM TDHGHNHKHA SHKTLTKADA EKALNLVLDS VISAIKSHHN INITGFGSFE
IHHRKAREGR NPKTGAKMKI DAYNQPTFRA GRKMKEACN
//
