GenomeNet

Database: UniProt
Entry: Q4V7F2
LinkDB: Q4V7F2
Original site: Q4V7F2 
ID   CREL1_RAT               Reviewed;         420 AA.
AC   Q4V7F2;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   16-JAN-2019, entry version 99.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 1;
DE   Flags: Precursor;
GN   Name=Creld1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
DR   EMBL; BC097951; AAH97951.1; -; mRNA.
DR   RefSeq; NP_001019954.1; NM_001024783.1.
DR   UniGene; Rn.6461; -.
DR   ProteinModelPortal; Q4V7F2; -.
DR   STRING; 10116.ENSRNOP00000013052; -.
DR   jPOST; Q4V7F2; -.
DR   PaxDb; Q4V7F2; -.
DR   PRIDE; Q4V7F2; -.
DR   Ensembl; ENSRNOT00000013052; ENSRNOP00000013052; ENSRNOG00000009414.
DR   GeneID; 312638; -.
DR   KEGG; rno:312638; -.
DR   UCSC; RGD:1309412; rat.
DR   CTD; 78987; -.
DR   RGD; 1309412; Creld1.
DR   eggNOG; KOG4260; Eukaryota.
DR   eggNOG; ENOG41107X2; LUCA.
DR   GeneTree; ENSGT00940000160255; -.
DR   HOGENOM; HOG000004778; -.
DR   HOVERGEN; HBG081344; -.
DR   InParanoid; Q4V7F2; -.
DR   OMA; FHRQQEA; -.
DR   OrthoDB; 883628at2759; -.
DR   PhylomeDB; Q4V7F2; -.
DR   TreeFam; TF316507; -.
DR   PRO; PR:Q4V7F2; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000009414; Expressed in 10 organ(s), highest expression level in skeletal muscle tissue.
DR   Genevisible; Q4V7F2; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 1.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; Laminin_EGF.
DR   Pfam; PF11938; DUF3456; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     29       {ECO:0000255}.
FT   CHAIN        30    420       Cysteine-rich with EGF-like domain
FT                                protein 1.
FT                                /FTId=PRO_0000042783.
FT   TOPO_DOM     30    362       Extracellular. {ECO:0000255}.
FT   TRANSMEM    363    383       Helical. {ECO:0000255}.
FT   TOPO_DOM    384    384       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    385    405       Helical. {ECO:0000255}.
FT   TOPO_DOM    406    420       Extracellular. {ECO:0000255}.
FT   DOMAIN      153    193       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      208    255       FU 1.
FT   REPEAT      268    315       FU 2.
FT   DOMAIN      305    342       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CARBOHYD    205    205       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    155    169       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    163    181       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    183    192       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    309    321       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    314    330       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    332    343       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   420 AA;  45697 MW;  5E424A5C21E7AAB8 CRC64;
     MAPQPLRGLV PFLLWCLSLF LSLPGPVWLQ PSPPPHSAPR AEPHPCHTCR ALVDSFNKGL
     ERTIRDNFGG GNTAWEEEKL SKYKDSETRL VEVLEGVCSK SDFECHRLLE LSEELVEAWW
     FHRQQEAPDL FQWLCSDSLK LCCPSGTFGP SCLPCPGGTE RPCGGYGQCE GEGTRGGSGH
     CDCQAGYGGE ACGQCGLGYF EAERNSSHLV CSACFGPCAR CTGPEESHCL QCRKGWALHH
     LKCVDIDECG TEQATCGAAQ FCVNTEGSYE CRDCAKACLG CMGAGPGRCK KCSRGYQQVG
     SKCLDVDECE TVVCPGENEQ CENTEGSYRC VCAEGFRQED GICVKEQIPE SAGFFAEMTE
     DEMVVLQQMF FGVIICALAT LAAKGDLVFT AIFIGAVAAM TGYWLSERSD RVLEGFIKGR
//
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