GenomeNet

Database: UniProt
Entry: Q4V7M2
LinkDB: Q4V7M2
Original site: Q4V7M2 
ID   CRE2B_XENLA             Reviewed;         361 AA.
AC   Q4V7M2;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   16-JAN-2019, entry version 65.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 2-B;
DE   Flags: Precursor;
GN   Name=creld2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Possible role in neuronal acetylcholine receptor
CC       transport. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
DR   EMBL; BC097826; AAH97826.1; -; mRNA.
DR   RefSeq; NP_001089538.1; NM_001096069.1.
DR   UniGene; Xl.24289; -.
DR   ProteinModelPortal; Q4V7M2; -.
DR   PRIDE; Q4V7M2; -.
DR   GeneID; 734593; -.
DR   KEGG; xla:734593; -.
DR   CTD; 734593; -.
DR   Xenbase; XB-GENE-6255881; creld2.
DR   HOVERGEN; HBG081344; -.
DR   OrthoDB; 883628at2759; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd00064; FU; 2.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; Laminin_EGF.
DR   Pfam; PF11938; DUF3456; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; EGF-like domain; Endoplasmic reticulum;
KW   Glycoprotein; Repeat; Secreted; Signal.
FT   SIGNAL        1     24       {ECO:0000255}.
FT   CHAIN        25    361       Cysteine-rich with EGF-like domain
FT                                protein 2-B.
FT                                /FTId=PRO_0000256250.
FT   DOMAIN      134    176       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      191    238       FU 1.
FT   REPEAT      251    298       FU 2.
FT   DOMAIN      288    329       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CARBOHYD    188    188       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    138    152       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    146    164       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    166    175       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    292    306       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    299    315       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    317    328       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   361 AA;  39515 MW;  8E342A145975774A CRC64;
     MNGSRAWRLA AWLLLCLSCS AAVARKDSCE TCTKLVERFH KGLENTAKKN FGGGNTAWEE
     KTLSKYESSE IRLVEIIENI CDSSDFECNH MVEEHEEQIE KWWFKMKQKY PDLLKWFCIE
     AIKVCCPSGS YGPDCLACLG GSERPCHGNG FCSGDGTRSG DGSCRCKAEY TGSFCLECSD
     GYYSSERNDT HAVCIACNQA CKTCNGPSNE DCKECNNGWV KDDGKCVDLN ECASEESPCK
     DSQYCLNTEG SFLCKECDGS CSGCSGEGPE SCKDCATGFV MLSGKCTDVD ECDASEKLCL
     RENEVCLNTA GSYKCTCSEG FEDKEGNCVK IMETENPEIT EGETGTPASD TNILNTAHED
     L
//
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