ID DNAI4_RAT Reviewed; 803 AA.
AC Q4V8G4; Q5XIP5;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 109.
DE RecName: Full=Dynein axonemal intermediate chain 4 {ECO:0000305};
DE AltName: Full=WD repeat-containing protein 78;
GN Name=Dnai4 {ECO:0000312|RGD:1311027}; Synonyms=Wdr78;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a critical role in the assembly of axonemal dynein
CC complex, thereby playing a role in ciliary motility.
CC {ECO:0000250|UniProtKB:E9PYY5}.
CC -!- SUBUNIT: Part of the multisubunit axonemal dynein complex formed at
CC least of two heavy chains and a number of intermediate and light
CC chains. Associated with axonemal dynein subunits such as, DNAH2, DNAI3,
CC and DYNLT1. Interacts with DYNLT1. {ECO:0000250|UniProtKB:E9PYY5}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000250|UniProtKB:E9PYY5}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:E9PYY5}. Dynein axonemal particle
CC {ECO:0000250|UniProtKB:Q6GPB9}.
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DR EMBL; BC083631; AAH83631.1; -; mRNA.
DR EMBL; BC097402; AAH97402.1; -; mRNA.
DR RefSeq; NP_001019957.1; NM_001024786.1.
DR AlphaFoldDB; Q4V8G4; -.
DR SMR; Q4V8G4; -.
DR STRING; 10116.ENSRNOP00000048851; -.
DR PhosphoSitePlus; Q4V8G4; -.
DR PaxDb; 10116-ENSRNOP00000048851; -.
DR GeneID; 313417; -.
DR KEGG; rno:313417; -.
DR UCSC; RGD:1311027; rat.
DR AGR; RGD:1311027; -.
DR CTD; 79819; -.
DR RGD; 1311027; Dnai4.
DR VEuPathDB; HostDB:ENSRNOG00000006999; -.
DR eggNOG; ENOG502QWGI; Eukaryota.
DR HOGENOM; CLU_015820_0_0_1; -.
DR InParanoid; Q4V8G4; -.
DR OrthoDB; 3088529at2759; -.
DR PhylomeDB; Q4V8G4; -.
DR TreeFam; TF300553; -.
DR PRO; PR:Q4V8G4; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000006999; Expressed in testis and 19 other cell types or tissues.
DR Genevisible; Q4V8G4; RN.
DR GO; GO:0005858; C:axonemal dynein complex; ISS:UniProtKB.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:0045504; F:dynein heavy chain binding; IBA:GO_Central.
DR GO; GO:0045503; F:dynein light chain binding; IBA:GO_Central.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12442:SF12; DYNEIN AXONEMAL INTERMEDIATE CHAIN 4; 1.
DR PANTHER; PTHR12442; DYNEIN INTERMEDIATE CHAIN; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Cytoplasm; Cytoskeleton; Flagellum;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..803
FT /note="Dynein axonemal intermediate chain 4"
FT /id="PRO_0000262774"
FT REPEAT 492..532
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 541..589
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 616..656
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 660..700
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 703..742
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 748..787
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 143..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 803 AA; 90198 MW; 77573CC6C09BDACD CRC64;
MPSSPTSTRK QTNFTASVSA QSRKSISFGN PKSTGGKGYA GANQSKIVAS RTMTFLPEMK
PAEKLNIASA KLVQVLDPRG VDVTPRPLYH PDPHAMPTKP SKLLTSQEGS MGSDYISSYS
LYQNTLNPSM LGQYTRSVIG SSSTVSKSSI STTESMTEDL EDPSYKRDRL ASFADVRVMR
APAEAAITKE ELERNVEIFL METETLRFFD LPTVMISTDS EEAEKVIEKN INYEILCRNR
LGNDLYVERM MQTFNGAPKN KDVQCDKIIM EEKGVMATTW DLYDSFNIPE ASLAAKRSAY
LSKASLLVRD RDPKIQDSES SSLMDIESVI LAKSHEDEED NSEKILKSDK LHQDLFYMER
VLMENVFQPK LAAYRQLPIY KELEPGQPEE DLQVVNKVTE DEVKKDEEEE METELEIEIT
TEQSTIPANL ERLWSFSCDL TKGLNVSSLS WNKANSDLLA VGYGNFGFKE QKRGMACCWS
IKNPMWPERI YQSPYGVTSV DFSISSPNLL AVGYHNGTVA IYNVQSNHNT PVLDSSESPQ
KHLGPVWQVQ WIEQDRGTTG DDRREILVSI SADGRISKWV IRKGLDCHDL MHLKRTTVTS
SKKGIEKEKK GEALISRQAP GMCFAFHTKD TNIYLAGTEE GLIHKCSCSY NEQYLETYRG
HKGPVYKVTW NPFCPDVFLS CSADWGVMIW HQDNVKPFFT FYPTTYVVYD VAWSPKSAYI
FAAANENRVE IWDLQISTLD PLIVNVANPG IKFTTVLFAK QTDCLLVGDS DGQVAVYELR
NMPTPTESGR GDVINVLLGP KAN
//
