ID Q4V9J8_DANRE Unreviewed; 227 AA.
AC Q4V9J8; A0A8M1N7E5;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=Basic helix-loop-helix family, member e23 {ECO:0000313|EMBL:AAH96864.1, ECO:0000313|Ensembl:ENSDARP00000054735};
DE SubName: Full=Class E basic helix-loop-helix protein 23 {ECO:0000313|RefSeq:NP_001025304.1};
GN Name=bhlhe23 {ECO:0000313|EMBL:AAH96864.1,
GN ECO:0000313|Ensembl:ENSDARP00000054735,
GN ECO:0000313|RefSeq:NP_001025304.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050913-22};
GN Synonyms=bhlhb4 {ECO:0000313|RefSeq:NP_001025304.1}, zgc:111964
GN {ECO:0000313|RefSeq:NP_001025304.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH96864.1};
RN [1] {ECO:0000313|EMBL:AAH96864.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye {ECO:0000313|EMBL:AAH96864.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001025304.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19449054; DOI=10.1007/s00239-009-9232-7;
RA Wang Y., Chen K., Yao Q., Zheng X., Yang Z.;
RT "Phylogenetic analysis of zebrafish basic helix-loop-helix transcription
RT factors.";
RL J. Mol. Evol. 68:629-640(2009).
RN [3] {ECO:0000313|RefSeq:NP_001025304.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=19344499;
RA Vitorino M., Jusuf P.R., Maurus D., Kimura Y., Higashijima S., Harris W.A.;
RT "Vsx2 in the zebrafish retina: restricted lineages through derepression.";
RL Neural Dev. 4:14-14(2009).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000054735}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000054735};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [5] {ECO:0000313|Ensembl:ENSDARP00000054735, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000054735};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001025304.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [7] {ECO:0000313|RefSeq:NP_001025304.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CR407550; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC096864; AAH96864.1; -; mRNA.
DR RefSeq; NP_001025304.1; NM_001030133.1.
DR STRING; 7955.ENSDARP00000054735; -.
DR PaxDb; 7955-ENSDARP00000054735; -.
DR Ensembl; ENSDART00000054736.5; ENSDARP00000054735.3; ENSDARG00000037588.5.
DR GeneID; 559796; -.
DR KEGG; dre:559796; -.
DR AGR; ZFIN:ZDB-GENE-050913-22; -.
DR CTD; 128408; -.
DR ZFIN; ZDB-GENE-050913-22; bhlhe23.
DR eggNOG; KOG3898; Eukaryota.
DR HOGENOM; CLU_070971_2_0_1; -.
DR OMA; AEKCSTY; -.
DR OrthoDB; 5324482at2759; -.
DR TreeFam; TF322733; -.
DR Proteomes; UP000000437; Chromosome 23.
DR Bgee; ENSDARG00000037588; Expressed in retina and 17 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0070888; F:E-box binding; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0061564; P:axon development; IBA:GO_Central.
DR GO; GO:0048663; P:neuron fate commitment; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007423; P:sensory organ development; IBA:GO_Central.
DR CDD; cd18953; bHLH_TS_bHLHe23_bHLHb4; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR PANTHER; PTHR19290; BASIC HELIX-LOOP-HELIX PROTEIN NEUROGENIN-RELATED; 1.
DR PANTHER; PTHR19290:SF53; CLASS E BASIC HELIX-LOOP-HELIX PROTEIN 23; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 104..158
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT REGION 42..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 24598 MW; B801A150F4FA885B CRC64;
MNVGDENLLK SISNDTLLDL TQRYGQSAFG FGAGHGAGSP GRFSLTPAAD FLSGQTGKSN
ESGGEQTSDE DDGFDNLESR KRGAGFDEEK HPGSLTKKSK EQRSLRLSIN ARERRRMHDL
NDALDGLRSV IPYAHSPSVR KLSKIATLLL AKNYILMQAQ ALEEMRRLVA YLNQGQTITS
PIPTALAPFG QAAVYPFSST ALATCAEKCN SFSGTPSNLF KHCNDKP
//
