ID Q4W9S4_ASPFU Unreviewed; 899 AA.
AC Q4W9S4;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Peroxisomal multifunctional beta-oxidation protein (MFP), putative {ECO:0000313|EMBL:EAL84539.1};
GN ORFNames=AFUA_4G03900 {ECO:0000313|EMBL:EAL84539.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL84539.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL84539.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL84539.1}.
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DR EMBL; AAHF01000016; EAL84539.1; -; Genomic_DNA.
DR RefSeq; XP_746577.1; XM_741484.1.
DR AlphaFoldDB; Q4W9S4; -.
DR STRING; 330879.Q4W9S4; -.
DR EnsemblFungi; EAL84539; EAL84539; AFUA_4G03900.
DR GeneID; 3503920; -.
DR KEGG; afm:AFUA_4G03900; -.
DR VEuPathDB; FungiDB:Afu4g03900; -.
DR eggNOG; KOG1206; Eukaryota.
DR HOGENOM; CLU_010194_18_0_1; -.
DR InParanoid; Q4W9S4; -.
DR OMA; WATKVHT; -.
DR OrthoDB; 2140828at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0044249; P:cellular biosynthetic process; IEA:UniProt.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 2.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 2.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 774..884
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT REGION 754..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 96808 MW; AF17A684FE829920 CRC64;
MSELRFDNQT VVVTGAGGGL GKAYATFFAS RGANVVVNDL GVSHSGEGAS SKAADVVVEE
IRAAGGKAVA NYDSVENGEA IIETAIKNFG RIDVLINNAG ILRDVSFKNM KDQDWDLINK
VHTYGAYKCA RAAWPHFRKQ KYGRIINTAS AAGLFGNFGQ ANYSAAKLGQ VGFTETLAKE
GAKYNIIANV IAPIAASRMT ATIMPPEVLE NLKPDWVVPL VAVLVHPSNT TESGSIFEVG
GGHMAKLRWE RAKGALLKTD ASLTPGAIAR KWKDVYDYSQ PEYPIGPADF MTLLENGMKT
PSAPAGEEPD LKGKVALVTG GGNGLGRSYC LLFAKLGASV VVNDLVDPEP VVQEIKKMGG
KAVGNKASCE DGDAVVKTAI DAFGRIDILV NNAGILRDKA FTNMNDDLWN AVINVHLRGT
YKVTKAAWPH MLKQKYGRIV NTTSTSGIYG NFGQANYAAA KLGILGFSRA LAIEGAKYNI
KVNTIAPNAG TNMTRTIMPE EMVQAFKPDY VAPMVALLCS DMCPEPSSKG LYECGSGWFS
STRWQRSGGH GFPVDVKLTP ETVLKNWKQI TDFDDGRADH PQDSQAGTEK VMANMSNRSG
GEGGNNILAN IEKAKQATTE GTAFDYIDRD IILYNLSVGA KRTDLPLVYE NNEHFQALPT
FGVIPWFNTA TPWNMDDIVA NFSPMMLLHG EQYMEIRKFP IPTEAKTLTY PKLIDVVDKG
KAALVVAGYT TKDAKTGEDL FYNESTVFIR GSGGFGGSPK PTASRPKGAT AAYNPPKRQP
DVVIEEKTSE DQAALYRLNG DRNPLHIDPE FSKVGGFKTP ILHGLCSLGI SGKHVFNKFG
AFKSLKVRFA GVVLPGQTLK TEMWKEGNTV IFQTTVVETG KPAILGAGAE LLEGAKAKL
//
