ID Q4WE32_ASPFU Unreviewed; 452 AA.
AC Q4WE32;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Geranylgeranyl pyrophosphate synthase, putative {ECO:0000313|EMBL:EAL86145.1};
DE EC=2.5.1.- {ECO:0000313|EMBL:EAL86145.1};
GN ORFNames=AFUA_5G01590 {ECO:0000313|EMBL:EAL86145.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL86145.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL86145.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004721}.
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the FPP/GGPP synthase
CC family. {ECO:0000256|ARBA:ARBA00038363}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the terpene synthase
CC family. {ECO:0000256|ARBA:ARBA00038372}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL86145.1}.
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DR EMBL; AAHF01000011; EAL86145.1; -; Genomic_DNA.
DR RefSeq; XP_748183.1; XM_743090.1.
DR AlphaFoldDB; Q4WE32; -.
DR STRING; 330879.Q4WE32; -.
DR EnsemblFungi; EAL86145; EAL86145; AFUA_5G01590.
DR GeneID; 3505571; -.
DR KEGG; afm:AFUA_5G01590; -.
DR VEuPathDB; FungiDB:Afu5g01590; -.
DR eggNOG; KOG0777; Eukaryota.
DR HOGENOM; CLU_605449_0_0_1; -.
DR InParanoid; Q4WE32; -.
DR OrthoDB; 5770at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0004659; F:prenyltransferase activity; IBA:GO_Central.
DR GO; GO:0046165; P:alcohol biosynthetic process; IEA:UniProt.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IBA:GO_Central.
DR GO; GO:0043386; P:mycotoxin biosynthetic process; IEA:UniProt.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 2.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR12001; GERANYLGERANYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR12001:SF72; THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G01210)-RELATED; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 2.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Isoprene biosynthesis {ECO:0000256|ARBA:ARBA00023229};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU004466}.
FT REGION 89..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 50450 MW; C114175E3E2F9BCB CRC64;
MAASALRASL GVGTVSSMHG LKGNAFMSRH LTAFMTKYGA AGKALMARCL DNWVQPQESR
VETEPVNFED SVARRVVTVG TSWEVERNRD PRGQNTVKTV MDSEGKSEQQ AKEKLRVAIL
EDERKYKLLM KQFALSTLDA PAHVQRFLVM LEVLLGGHHI WSAACGRYKR RAPSVGNPFL
RRESIIPNRV EDANERAASP VALGNSALLD PVHYIQSLPS KNMRTKLVDA LNLWFQLPHH
LVDTVKGTVD DLHNSTLILD DIQDSSYLRR GFAATHHVFG SAQCINSATY LLVQAASRLS
VHNEQYPAVI TVFLDGLKEL ALGQSWDLNW RSTGYCPSTE EYMAMVDGKT GVMFDMIVRM
MHCFSSSQTV PVSELSQLTQ LLGRWYQVRD DYQNLQDAQY TAQKGFCEDL DEGKLSYPLT
RCTPADVGAP AEIQKADRCR PFQPGGHDRS AE
//
