ID Q4WGN9_ASPFU Unreviewed; 2004 AA.
AC Q4WGN9;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Guanyl-nucleotide exchange factor (Sec7), putative {ECO:0000313|EMBL:EAL86902.1};
GN ORFNames=AFUA_7G05700 {ECO:0000313|EMBL:EAL86902.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL86902.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL86902.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL86902.1}.
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DR EMBL; AAHF01000009; EAL86902.1; -; Genomic_DNA.
DR RefSeq; XP_748940.1; XM_743847.1.
DR STRING; 330879.Q4WGN9; -.
DR EnsemblFungi; EAL86902; EAL86902; AFUA_7G05700.
DR GeneID; 3506620; -.
DR KEGG; afm:AFUA_7G05700; -.
DR VEuPathDB; FungiDB:Afu7g05700; -.
DR eggNOG; KOG0929; Eukaryota.
DR HOGENOM; CLU_000691_1_1_1; -.
DR InParanoid; Q4WGN9; -.
DR OMA; MENQVYE; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000002530; Chromosome 7.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032629; DCB_dom.
DR InterPro; IPR015403; Mon2/Sec7/BIG1-like_HDS.
DR InterPro; IPR032691; Mon2/Sec7/BIG1-like_HUS.
DR InterPro; IPR046455; Sec7/BIG1-like_C.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF375; LD29171P; 1.
DR Pfam; PF20252; BIG2_C; 1.
DR Pfam; PF16213; DCB; 1.
DR Pfam; PF01369; Sec7; 1.
DR Pfam; PF09324; Sec7-like_HDS; 1.
DR Pfam; PF12783; Sec7-like_HUS; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 798..987
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT REGION 1..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1192..1233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1698..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 63..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..107
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1706..1721
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1722..1743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2004 AA; 225551 MW; 985CE30E0BA92457 CRC64;
MADVENGSSQ EPNQTSLVLP QGDNKENTVD TSTPVETEDA VEEDSKPPLP LESQRQKIDL
DEVTDSNSPQ IKVDSSEITE TADRPPSPPN DAADAERPEE HGSPQRDLKA NDVTNSGNDQ
AEAPPGDSGD KQDDGAVPQF ELTPGTRLRS DSRSTTATYA TQRSVPVSSA VFIVNALETI
GASKEAKKSK ELDDAVKSAL ANVKQSDRLP IDPELIFRPL QLATKSLSIP LQVTALDCIG
KLITYSYFAF PSSQDRKGSE IEATPEQTPL IERAIDAICD CFENEATPFE IQQQIIKSLL
AAVLNDKIVV HGAGLLKAVR QIYNIFIYSK SNQNQQIAQG SLTQMVSTVF DRVRVRLELK
ELRLREGEKG QENTPDAATA ETVEVPLSTD QDQTSDAASV VAPDQPVAKE PGEKLTLQSF
ESGKDVTSVA DNAPTMVTRA KLSQKRTQSL SSTSGEEKED GDGTTDDDED EIYIKDAFLV
FRALCKLSHK ILSHEQQQDL KSQNMRSKLL SLHLLHYLIN NHVSVFTSPL LTIRNNSNSS
DAMTLLQAVR PHLCLSLSRN GSSSVPRVFE VCCEIFWLML KHMRVMMKKE LEVFLKEIYL
AILEKRNSPA FQKQYFMELV ERLADDPRAL VEIYLNYDCD RTALENIFQN IIEQVSRYSS
VPVAVSAVQQ QHYQEHHVKI SKVGADWHHR GTLPPTLTTA HITSIQQPTS QNVPSEYILK
NQSLECLVEI LQSLDNWASQ RIDGPAAGVT NLLSQKSLDN SRESMDTNAA TFLSSPRVEG
TDDSTGRSTP VAEDDPSQIE KVKQRKTALM NAIQQFNFKA KRGIKLFIQE GFIRSDSPED
IASFLFRNDR LDKAMIGEYL GEGDAENIAI MHAFVDQMDF SKRRFVDALR QFLQHFRLPG
EAQKIDRFML KFAERYVTQN PNAFANADTA YVLAYSVIML NTDQHSAKIK GRRMTKEDFI
KNNRGINDNQ DLPDEYLGSI FDEIANNEIV LDTEREHAAN LGIATSTTTG GLASRAGQVF
ATVGRDIQGE KYAQASEEMA NKTEQLYRSL IRAQRKTAVR EALSRFIPAT SVRHVGSMFN
VTWMSFLSGL SAPMQDTQNL ETIKLCMEGM KLAIRISCAF DLETPRVAFV TGLAKFTNLG
NVREMVPKNV EALKALLDVA LTEGNNLKSS WREVLTCVSQ LDRLQLLTDG VDEGSLPDPS
RARIVPQTPS DGSRKSMQAS RRPPRPRSVN GPTAFRSEVA MESRSAEMIR GVDRIFTNTA
NLTHEAIIDF VRALSEVSWQ EIQSSGQTKS PRTYSLQKLV EISYYNMTRV RIEWSKIWDV
LGQHFNQVGC HTNTTVVFFA LDSLRQLSMR FLEIEELPGF KFQKDFLKPF EHVMANSNAV
TVKDMILRCL IQMIQARGDN IRSGWKTMFG VFTVAAREPY EGIVNMALEH VTQIYNTRFG
VVITQGAFPD LIVCLTEFSK NMRFQKKSLQ AIETLKSTVT KMLRTPECPL SHRGITSEGV
QEDGTNLAKQ LSRQSQEEQF WYPILIAFQD VLMTGDDLEV RSRALTYLFD TLIRHGGDFP
QEFWDVLWRQ LLYPIFVVLH SKSEMSKVPN HEELSVWLST TMIQALRNMI TLFTHYFDAL
EYMLGRILEL LTLCICQEND TIARIGSNCL QQLILQNVAK FQQEHWTKVV GAFVELFSRT
TAYELFTAAA SISSKPASIR NENGEASNED GLHKTEQETA ESTRVQETPS DAPKVNGSQP
VTSEHEEGDM PAASTPELED YRPQAEPQQQ PAAVTVARRR FFNRIITNCV LQLLMIETVH
ELFSNDKVYA EIPSHELLRL MGLLKKSYQF AKKFNEDKEL RMQLWRQGFM KQPPNLLKQE
SGSAATYVHI LFRMYHDERE ERKSSRGETE AALIPLCADI IRSFVRLDED SQHRNIVAWR
PVVVDVIEGY TNFPSEGFDK HIETFYPLAV DLLGRDLNPE IRLALQSLFR RIGEARLGIA
AVQTPISPRS SISQHHSRRY SRDH
//
