ID Q4WIB1_ASPFU Unreviewed; 857 AA.
AC Q4WIB1;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=PA and RING finger domain protein {ECO:0000313|EMBL:EAL87344.1};
GN ORFNames=AFUA_2G02470 {ECO:0000313|EMBL:EAL87344.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL87344.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL87344.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL87344.1}.
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DR EMBL; AAHF01000008; EAL87344.1; -; Genomic_DNA.
DR RefSeq; XP_749382.1; XM_744289.1.
DR AlphaFoldDB; Q4WIB1; -.
DR STRING; 330879.Q4WIB1; -.
DR EnsemblFungi; EAL87344; EAL87344; AFUA_2G02470.
DR GeneID; 3506732; -.
DR KEGG; afm:AFUA_2G02470; -.
DR VEuPathDB; FungiDB:Afu2g02470; -.
DR eggNOG; KOG0800; Eukaryota.
DR HOGENOM; CLU_007230_0_0_1; -.
DR InParanoid; Q4WIB1; -.
DR OMA; SGNIDWV; -.
DR OrthoDB; 206729at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd04813; PA_1; 1.
DR CDD; cd16454; RING-H2_PA-TM-RING; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR22765; RING FINGER AND PROTEASE ASSOCIATED DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR22765:SF483; RING FINGER PROTEIN MUG145; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..857
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004246242"
FT TRANSMEM 582..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 709..752
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 106..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 761..832
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 450..485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..786
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 91708 MW; DC3812B29D3ECC3F CRC64;
MRPPRLVSIV FCILFFPIFL TLFSALSSSP RVADPSSLAG QTTGFHAFFS FNIPSSLFPP
SAIISLTDDN STFFLARPAA FGPLLSDKGL SGPLWVGSGF GEKTSGGAEG ELGCSDIPGW
GDGDSRRSPD KSTIAADKTS SSGIRDGLAA SLGQHRADPQ QESDSEHLAA GVASPPSTND
GTDDHLHHPL PDSDVVDAGA PEKPRERQNK PAAHADIQSL QESAEIDGKV VLLSRGGCGF
LEKVKWAQRR GAIAVIVGDD TRGGSLVTMY ARGDTSNVTI PAVFTSYTTA HLLSSLMPPQ
AGAESSLDEK AASSRTVVSS GPDKQRLSPT TTTSVTPSST PTTQAAVDEQ LQTAPRPKTG
FFHSLLSLLG LGRSNNGHAL QKFEDSRRPP NSGNIDWVRL GDKQQSNKPH NSAAHDRKES
ESVSSLADGD GFIIGVQDWR DPDLVPARTI SLPSPSSVAS SAKTESGNSA KSQKKTSNSP
KGGSITPGSG EYRSVDRSSD NKEVPSRDGS PVNSAGNAGS DKGWFFKRFF APRRTEGANL
YKPANNKMRR NTDQNAKVTE HEGLWVTLTP TSMSTSPFFD TLLVLVVSPL LTLTVVYALL
LIRSRIRRRR WRAPKSIVER LPVRTYHTIP TPSSAASSSR SSSPGPVSPT SPLLGSRSRP
ELAPSRSSFL RSGTAEAKKT RNMDSAKGEK SGSASSVWRR KYTGRQVECV VCLEEYIDGQ
SRVMSLPCGH EFHAECITPW LTTRRRTCPI CKGDVVRSMA QNTTAESRDS SQRMVDGDDH
HGFESHRSVS SAPMLIANPG EEETSAPEHY GASDLGPLQG HASSAPPSSS WRNMASLSLS
ALSGDTIWHQ TQPDNDR
//
