ID Q4WP24_ASPFU Unreviewed; 1228 AA.
AC Q4WP24;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 2.
DT 24-JAN-2024, entry version 86.
DE SubName: Full=Cation chloride cotransporter, putative {ECO:0000313|EMBL:EAL90010.2};
GN ORFNames=AFUA_4G07770 {ECO:0000313|EMBL:EAL90010.2};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL90010.2, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL90010.2, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL90010.2}.
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DR EMBL; AAHF01000005; EAL90010.2; -; Genomic_DNA.
DR RefSeq; XP_752048.2; XM_746955.2.
DR AlphaFoldDB; Q4WP24; -.
DR EnsemblFungi; EAL90010; EAL90010; AFUA_4G07770.
DR GeneID; 3509636; -.
DR KEGG; afm:AFUA_4G07770; -.
DR VEuPathDB; FungiDB:Afu4g07770; -.
DR eggNOG; KOG1288; Eukaryota.
DR HOGENOM; CLU_001883_4_0_1; -.
DR InParanoid; Q4WP24; -.
DR OMA; NDLPCRA; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0005774; C:vacuolar membrane; IEA:EnsemblFungi.
DR GO; GO:1990816; C:vacuole-mitochondrion membrane contact site; IEA:EnsemblFungi.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IBA:GO_Central.
DR GO; GO:0006884; P:cell volume homeostasis; IBA:GO_Central.
DR GO; GO:0055064; P:chloride ion homeostasis; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR GO; GO:0055075; P:potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0034486; P:vacuolar transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF72; GH08340P; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 128..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..273
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 349..370
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..403
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..492
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 498..519
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..595
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 610..692
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1001..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1065..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 712..729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1050
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1065..1099
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1228 AA; 135035 MW; 124042291FADDEAC CRC64;
MSRRRPNFST RTAEEDVSRL EPTDSAQASP EANSRFLDWR TTVSSRPFEP LNASSPRSDN
QRHPSSTGLF SSVSRWWHRR ESGRQDSGPD NVAANVSHST GPRREDSSPH KKEKYASAHR
ASEAAYKLGT FSGVFVPTTL NVLSILMFLR FGFVLGQAGL LGMLGLLVAS YTINLVTTMS
LSAIATNGTV RGGGAYYLIS RSLGPEFGGS IGIVFYLGYV LNTGMNAVGL VDCFTQNFGT
ESGNWANFLE EGFWWQYLWG TVVLVLCTTI CLAGSSMFAR ASNGLLVILL VATFSIPLSV
IAMKPFSNPE LNIEFTGIRL QTLMDNLKPR LTKGAAGSQI NGRENFQDLF GILFPATGGI
FAGASMSGDL KNPSKSIPKG TLYGLALTFV TYTLVILAMA ASITRESFYK NTSVLQLVNI
SGVVILLGEF ATSFFSSLMG VIGSAKLLQA IARDSLLPGL SLLGKGSKKS DDPVYAIILT
FVFAQLTMLF DINQIASFVT MTYLMTFLVT NLACFLLKIG SAPNFRPSFH YFNWQTAAAG
TLVCGASMFF VDGLYATGCV GILISWGDVS QSLIYHQVRK YLLRLRQEHV KFWRPQILLF
VTNLDEQYKM VSFCNSLKKG ALFVLGHVLV TDDFSAAVPE ARRQQSAWTK LVEYSRVKAF
VNIAVAPSIE WGVRNVVLNS GLGGMRPNIV VIDQFRKGQS LGEVLQLPGH RKDSTNSKRY
SHETHGESLE NGTHGLSRSC SMSCRSYVTI LEDLLFKLRI NVAVAKGFED LELPSPDGQH
TKKYIDLWPI QMSAELGADT ESKQNVLTTN FDTYTLILQL GCILNTVPSW KKTYRLRVAV
FVEYETDVED ERRRVEALLE KLRIEAEVLV FWLACGDLEA YRIIVNGDMS PDTKEAQDRV
HAVLEQEDWW QELRQFRSNS KDFQGTSGHL SVGSLPERMS SWSGPWGHEM TRSQSQMAGG
LRKFIQSRRR RSISSFKGFG GVSLGMKTHR LLDSLVDYDS SASESSSDSE FEPYASDDDG
GEEGTLETDG HNSQSHEAVT SPITDQMSPQ EITVGQDLPS IITTGEEASP KSKVGLTQPP
ISRSPSTNRF SSSPIPEARV SSEETAGPSI MFAPSSSPPR FPNRLESIYT RRSSSGARSA
SGYPKQASVP LSFDDLPSRA QHLILNELMA RQSSQTAVIF TTLPSPSEGT AGSEETSESY
LRDLEVLWQG LPPCLLVHSN SMTVTMNL
//
