ID Q4WP94_ASPFU Unreviewed; 1140 AA.
AC Q4WP94;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=26S proteasome regulatory subunit RPN2 {ECO:0000256|PIRNR:PIRNR015947};
GN ORFNames=AFUA_4G08480 {ECO:0000313|EMBL:EAL89940.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL89940.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL89940.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Acts as a regulatory subunit of the 26S proteasome which is
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC {ECO:0000256|PIRNR:PIRNR015947}.
CC -!- SIMILARITY: Belongs to the proteasome subunit S1 family.
CC {ECO:0000256|ARBA:ARBA00006308, ECO:0000256|PIRNR:PIRNR015947}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL89940.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHF01000005; EAL89940.1; -; Genomic_DNA.
DR RefSeq; XP_751978.1; XM_746885.1.
DR AlphaFoldDB; Q4WP94; -.
DR STRING; 330879.Q4WP94; -.
DR EnsemblFungi; EAL89940; EAL89940; AFUA_4G08480.
DR GeneID; 3509237; -.
DR KEGG; afm:AFUA_4G08480; -.
DR VEuPathDB; FungiDB:Afu4g08480; -.
DR eggNOG; KOG2062; Eukaryota.
DR HOGENOM; CLU_002323_0_1_1; -.
DR InParanoid; Q4WP94; -.
DR OMA; IMFGRQE; -.
DR OrthoDB; 151732at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008540; C:proteasome regulatory particle, base subcomplex; IBA:GO_Central.
DR GO; GO:0034515; C:proteasome storage granule; IBA:GO_Central.
DR GO; GO:0004175; F:endopeptidase activity; IEA:EnsemblFungi.
DR GO; GO:0030234; F:enzyme regulator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:EnsemblFungi.
DR GO; GO:0043248; P:proteasome assembly; IEA:EnsemblFungi.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0042176; P:regulation of protein catabolic process; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR016642; 26S_Psome_Rpn2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002015; Proteasome/cyclosome_rpt.
DR InterPro; IPR048570; PSMD1_RPN2_N.
DR InterPro; IPR040623; RPN2_C.
DR PANTHER; PTHR10943; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10943:SF2; 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF01851; PC_rep; 1.
DR Pfam; PF18004; RPN2_C; 1.
DR Pfam; PF21505; RPN2_N; 2.
DR PIRSF; PIRSF015947; 26S_Psome_Rpn2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Proteasome {ECO:0000256|ARBA:ARBA00022942, ECO:0000256|PIRNR:PIRNR015947};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..118
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 194..433
FT /note="26S proteasome non-ATPase regulatory subunit 1/RPN2
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21505"
FT DOMAIN 880..1052
FT /note="26S proteasome regulatory subunit RPN2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18004"
FT REGION 119..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..949
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1140 AA; 124735 MW; B50D8609D90C15A6 CRC64;
MVGLASAAGL VGFLSEPDPE LRVFALKTLD SQIDLLWTEV VDAVPQIEAL YEDESFPERE
LAALVAAKVY YHLQEYNESM VFALGAGKLF KLENGGEFEE TIIAKCVDTF ISLSAAQRPA
AGDPSANLNN SFPTSGEGAT STSASLTSPI TPFSQSTLPS KSLLSRQEVP GLDAAHPGGE
DVSVKHDETT LVLKRGVQGQ LQSVIERLFE QCFVQKRYRQ VIGIAIEAKN LDVLRRAIIR
ASEDGKKHGG SRRSEELMEY VLDICMGIVQ ERAFRNEILK LILELLNEIP APDYFSIAKC
VVFLNEHSMA SVILRQLVEK GDARSLAVAY QISFDLYDNS TQEFLKKVRE EIAELVPEEQ
QPDGSKTESQ EEPKESDPLL QDQSSSEQSR SLGLNNTQAK LSDEARTAFK NILEILDGIK
SIQLNLEFLY RNNKADIAIL NKVRDSLEAR NSIFHTAVTL SNAFMHAGTT HDKFFRDNLE
WLGKAVNWSK FTATAALGVI HRGNLSQGQK LLQPYLPREH IAGVGGSGSV YSQGGSLYAF
GLIYANHGGM AVDMIRDHFK KATEEVVQHG GALGLGVAGM ATGDEGIYED LRNVLYTDSA
LNGEAVGLAM GLVMLGTGNM RALEDMIQYA HDTQHEKIVR GLAMGMALIM YGRQEAADEL
INGLLGDPDP TLRYGGIMTI ALAYCGTGSN KAVRKLLHVA VSDVNDDVRR VAVLSLGFIL
FRKYQSVPRM VELLSESYNP HVRYGAAMAL GISCAGTGLD EAIDLLEPML KDSTDFVRQG
ALIALAMVLV QQNEAMNPRV SSLRKAMMKM IGDRHEDAMA KFGCAVALGI IDAGGRNCTI
SLQTQTGNLN MPGIVGTAVF IQYWYWFPLT HFLSLSFTPT AVIGVDQKLE VPFFKFHSNT
RPSLFDYPPE QQVKAEEAPE KVKTAVLSTT AQAKRRAQRR EKQQRRESMD VDQTPTTPKV
SDQLPEKMET DEGAEKPEEE AKEGEKGAGD GPKKKAEREK VGYELENMSR VLPAQLKYLT
FPDPRYEPVK RPTGGVVVVV LDKNPDEPRE TIEMKASKEV RQPAATAESL QDRLQAAIGA
AALQTPQRDA GRMPLGADLT AAAGAAAAAG VLTAVDEDEE GGEEAPVPEE FEYESEGMEE
//
