GenomeNet

Database: UniProt
Entry: Q4WRV2
LinkDB: Q4WRV2
Original site: Q4WRV2 
ID   DRS1_ASPFU              Reviewed;         830 AA.
AC   Q4WRV2;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   16-OCT-2019, entry version 97.
DE   RecName: Full=ATP-dependent RNA helicase drs1;
DE            EC=3.6.4.13;
GN   Name=drs1; ORFNames=AFUA_1G14990;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
RA   Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
RA   Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
RA   Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
RA   Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
RA   Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
RA   Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
RA   Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
RA   Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
RA   Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
RA   Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
RA   Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
RA   Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
RA   Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
RA   White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
RA   Machida M., Hall N., Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in ribosome assembly.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with pre-ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; AAHF01000004; EAL90830.1; -; Genomic_DNA.
DR   RefSeq; XP_752868.1; XM_747775.1.
DR   SMR; Q4WRV2; -.
DR   STRING; 746128.CADAFUBP00001426; -.
DR   PRIDE; Q4WRV2; -.
DR   EnsemblFungi; EAL90830; EAL90830; AFUA_1G14990.
DR   GeneID; 3509891; -.
DR   KEGG; afm:AFUA_1G14990; -.
DR   EuPathDB; FungiDB:Afu1g14990; -.
DR   HOGENOM; HOG000265456; -.
DR   InParanoid; Q4WRV2; -.
DR   KO; K13181; -.
DR   OMA; HEPERSW; -.
DR   OrthoDB; 268859at2759; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   Proteomes; UP000002530; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding.
FT   CHAIN         1    830       ATP-dependent RNA helicase drs1.
FT                                /FTId=PRO_0000232240.
FT   DOMAIN      341    515       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      542    689       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     354    361       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED      689    735       {ECO:0000255}.
FT   MOTIF       310    338       Q motif.
FT   MOTIF       463    466       DEAD box.
FT   COMPBIAS    769    830       Lys-rich.
SQ   SEQUENCE   830 AA;  91618 MW;  30CC22B70EDF7FCC CRC64;
     MAPNAATKKR AAARDDDFVL TLSDDENDIF ENGVEEDGDN AQEDTLSSSK KRKREAAEAP
     KGKNKKQKQL KKSKKGESAA GAVSDDQSSE EDEAEAMDAG EDDGALDSEF EFDVGGNANT
     GVIEGFDGWE ARNGASLADA PKNGDKKAVD IDDIISRRKA KKEAELKKKQ QKEKKRREEE
     GEEESEGEDA DSDGGMSVDF QDDELLAADG FGMGADGADE SDDDVENGSN DSDDSEGKGS
     EDEESGDEYN DDDAASDNDS VATPVHHPDD EAASDEESEA ESEVDAEEAE KRKAFFAPEE
     KSTAVSTFNR SFQDFNLSRP ILRGLASVNF TTPTPIQQKT IPVALLGKDI VGSAVTGSGK
     TAAFVVPILE RLLFRPRKVP TSRVAILMPT RELAVQCYNV ATKLATHTDI TFCQLVGGFS
     LREQENILKK RPDVIIATPG RFIDHMRNSP SFTVDTLEIL VLDEADRMLE DGFADELNEI
     LTTIPKSRQT MLFSATMTDS VDKLIRVGLN RPVRLMVDSK KNTSMNLTQE FVRLRPGRED
     KRLGYLLYLC NEIYTGRVIV FFRQKREAHR VRIVFGLLGL KAAELHGSMS QEQRIKSVEN
     FREGKVAFLL ATDLASRGLD IKGVETVINY EAPQSHEIYL HRVGRTARAG RSGRACTIAA
     EPDRKIVKSA VKAGKAQGAK IVSRVVDPAV ADEWAAKAKG LEDEIEEVLQ EEKLEKQMAQ
     AEMQVTKGEN LIKHEAEIMS RPKRTWFETE RDKRAARKLG ATELNGPSKK DKVKLSNKDK
     KRLDDARQRH EGNIGWKKGK ADREAPKQGK NKGGKTKSDK KNKIKMKGKK
//
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