GenomeNet

Database: UniProt
Entry: Q4WT99
LinkDB: Q4WT99
Original site: Q4WT99 
ID   PRP5_ASPFU              Reviewed;        1211 AA.
AC   Q4WT99;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   16-OCT-2019, entry version 99.
DE   RecName: Full=Pre-mRNA-processing ATP-dependent RNA helicase prp5;
DE            EC=3.6.4.13;
GN   Name=prp5; ORFNames=AFUA_1G10050;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
RA   Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
RA   Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
RA   Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
RA   Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
RA   Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
RA   Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
RA   Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
RA   Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
RA   Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
RA   Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
RA   Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
RA   Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
RA   Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
RA   White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
RA   Machida M., Hall N., Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: ATP-dependent RNA helicase involved spliceosome assembly
CC       and in nuclear splicing. Catalyzes an ATP-dependent conformational
CC       change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2
CC       snRNP association with intron RNA (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX46/PRP5
CC       subfamily. {ECO:0000305}.
DR   EMBL; AAHF01000004; EAL90333.1; -; Genomic_DNA.
DR   RefSeq; XP_752371.1; XM_747278.1.
DR   SMR; Q4WT99; -.
DR   STRING; 746128.CADAFUBP00000929; -.
DR   PRIDE; Q4WT99; -.
DR   EnsemblFungi; EAL90333; EAL90333; AFUA_1G10050.
DR   GeneID; 3510546; -.
DR   KEGG; afm:AFUA_1G10050; -.
DR   EuPathDB; FungiDB:Afu1g10050; -.
DR   HOGENOM; HOG000007229; -.
DR   InParanoid; Q4WT99; -.
DR   KO; K12811; -.
DR   OMA; SKFHSIR; -.
DR   OrthoDB; 245118at2759; -.
DR   Proteomes; UP000002530; Chromosome 1.
DR   Proteomes; UP000002530; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase; mRNA processing;
KW   mRNA splicing; Nucleotide-binding; Nucleus; Reference proteome.
FT   CHAIN         1   1211       Pre-mRNA-processing ATP-dependent RNA
FT                                helicase prp5.
FT                                /FTId=PRO_0000232357.
FT   DOMAIN      606    784       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      811    961       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     619    626       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       575    603       Q motif.
FT   MOTIF       732    735       DEAD box.
FT   COMPBIAS     21    143       Arg-rich.
SQ   SEQUENCE   1211 AA;  133782 MW;  206E86EE324B2C8A CRC64;
     MARHGDTRSP SPVGSTYSSS RRSRRDDDRY EKSRRDDLRS YRRSRSPERR YRDRDRDSYR
     RRDRSVDRRD DHRDEDSYRS SRRDRSRDRR RSRDRGDDRD HRRKSRERDY RSRRDDSRDR
     ARRRTDDSAD LKHKSRRDDS RTRNLDSKPR EASKPSTPAP TAPTEDEKRA ERLAKLEAWK
     QKQAAERERK QREAAAAGGA RSILEEIDRK SGLSPAVGSP QSPATPTTDA TPTPYSGKFD
     PKAIVRNAAP APSTPAVLGN DVAVPQSAKA SASSSSMNNH VQANKHPAAN STTSCKLYIP
     TIRFLQIANV TCTATSTVKR NVGGFGLGAK QVADAEKSSA VKTLGFGEEE SKRKKLERLP
     TPPLEDAKDD MGAVDAAVED EDDVDMQDGG TEEENAAAAR AAAERREERL QSEALRAQSK
     EAALQSNGDV EMNDVPHQAE SEKMEVDAAE EEVDPLDAFM SELAETAPPK KTTGARFTKA
     KDQQPEAMFG DEHDVDLTAV GEGDADDFLA IANKAKKKKD IPTVDHEKME YEPFRKKFYT
     EPSNLAEMTD EEAASLRLEL DGIKVRGVDV PKPVMKWSQC GLGVQTLDVI QKLGYENPTS
     IQSQAIPAIM SGRDVIGVAK TGSGKTIAFL IPMFRHIRDQ RPLENMEGPI GLIMTPTREL
     ATQIHKDCKP FLKALNLRAV CAYGGAPIKD QIAELKRGAE IVVCTPGRMI DLLAANAGRV
     TNLRRVTYVV LDEADRMFDM GFEPQVMKIM ANIRPDRQTV LFSATFPRNM EALARKSLTK
     PIEIVVGGKS VVAPEITQIV EVRNEDTKFV RLLEILGNLY SDDANEDARA LIFVDRQEAA
     DTLLRELMRK GYPCMSIHGG KDQIDRDSTI EDFKAGIFPV LIATSVAARG LDVKQLKLVV
     NYDAPNHLED YVHRAGRTGR AGNTGTAVTF LTEEQERYSV DIAKALRQSG QKVPEPVQKM
     VDSFLEKVKA GKEKASASGF GGKGLERLDQ ERDAARMRER RTYKTGEEGE DEEDKEDKAE
     KADERFSKIV SSVQSAAAAA TTPLPGVPKG IDLDGKITVH RTEKDPAGAS KNPLDKVGSA
     VADIHARLSR AGVMRSGVPI DNRGPDAGAF HATLEINDFP QKARWAVTNR TNVAKILEAT
     GTSITTKGSF YPAGKEPGPG ENPKLYILVE GETELAVTNA MRELMRLLKE GTLAAADSDA
     RAPVGGRYNV V
//
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