ID Q4WVP0_ASPFU Unreviewed; 588 AA.
AC Q4WVP0;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=AFUA_5G12790 {ECO:0000313|EMBL:EAL91336.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL91336.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL91336.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL91336.1}.
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DR EMBL; AAHF01000003; EAL91336.1; -; Genomic_DNA.
DR RefSeq; XP_753374.1; XM_748281.1.
DR AlphaFoldDB; Q4WVP0; -.
DR STRING; 330879.Q4WVP0; -.
DR EnsemblFungi; EAL91336; EAL91336; AFUA_5G12790.
DR GeneID; 3511681; -.
DR KEGG; afm:AFUA_5G12790; -.
DR VEuPathDB; FungiDB:Afu5g12790; -.
DR eggNOG; KOG1684; Eukaryota.
DR HOGENOM; CLU_009834_22_0_1; -.
DR InParanoid; Q4WVP0; -.
DR OMA; EWEKSDM; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000002530; Chromosome 5.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IBA:GO_Central.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0006574; P:valine catabolic process; IBA:GO_Central.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:EAL91336.1};
KW Lyase {ECO:0000313|EMBL:EAL91336.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 162..506
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 588 AA; 65623 MW; 759F77157E7F6354 CRC64;
MFKPPLCSEF RCRTARNRGI GDVLGSKTVH LVQLPAEENQ TARKTPRSSV HPKRRNDFLS
RVISTNFLHF HSLSLSPQRR TVVCLDVTST QFLPLTNAGE LDLAGFITNA SPRQSDESSF
RGCCEGMLYS LSLFAMSTAP ELPKELPGDE PDDVLFSSLY GVRLIELNRP KKLNSLNGSM
ARKILPRLKE WEKSQLANIV MLSGAGTKAL CAGGDVASLA LQNEQGPEGQ QKSTDFFGLE
YRLDHIIATY TKPFISVMDG ITMGGGVGLS VHAPFRIATE RTVFAMPETT IGFFPDVGGS
FFLPRLDGEI GTYLALTSER LNGVQALYAG IATHYFHSSV LSNLTARLAE LVFRDHASLA
ERLDLVNKTM AEFSVGLPPV EQEPIQLAGS LRSAIDRCFK HNTVEEIFRA LEQETVHKEW
AQKTLETLSS RSPTSLKVTL RQMRVGKKWS ISETFQREYQ IAAQFMKHPD FVEGVKARLM
SKPPRQATWQ PATLEEVTND AVDAFFKLPA DKSRLTLFNK TDYKQYPHAY GLPSEAEIEK
FVRDSSESAS KTVADFVEKW GHKEGVREKV AEVLARRTVQ TPEGLRWE
//
