ID Q4WYB3_ASPFU Unreviewed; 1562 AA.
AC Q4WYB3;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=Guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EAL92340.1};
GN ORFNames=AFUA_3G12430 {ECO:0000313|EMBL:EAL92340.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL92340.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL92340.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL92340.1}.
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DR EMBL; AAHF01000002; EAL92340.1; -; Genomic_DNA.
DR RefSeq; XP_754378.1; XM_749285.1.
DR STRING; 330879.Q4WYB3; -.
DR EnsemblFungi; EAL92340; EAL92340; AFUA_3G12430.
DR GeneID; 3512533; -.
DR KEGG; afm:AFUA_3G12430; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_001471_0_0_1; -.
DR InParanoid; Q4WYB3; -.
DR OMA; ICNYATM; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 260..384
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1316..1559
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 880..969
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1017..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..137
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 603..631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 647..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..969
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1562 AA; 172814 MW; D791156E15CBBB96 CRC64;
MNHLDSFRPI QNPLHKEPHP ISYSPPPARS KTNHLHVQSR SHDGNDPSRW SNSQLSELRP
EFISEEAGED GDSVATDEAA PEYNSQHQHR QRAHSFSTIS EQQSVSGEKR YGEFRIFIDR
PDDRPRTADE SRRPTLDIPI PHYRLGTPQF NTEGSAALHS SVYSRASLSD NFRVSGFLRE
NWSASPGPGP NVYIGDSIQP EQPSFAASIF SGQPAMEMPR ASTATVNPVF YELKEPIEPS
IYDHLSSIMH DGSVVRYISG TKDIGAATPA RLVAQISSES FMDYELVSDF FLTFRSYLSP
GNLLSLLLAR LQWAINRLQD DGRIIRIRTF AALRHWILNY FADDFVPDYD LRARFCDTIN
AMYDNVKARE GGGTSDLKIL IDLKRCWHGK CAAYWELPTG HIAPGTAIVP GGHDFEAGPK
GEGNAEEHEY DSTTPEVNQE HQTGVQQSLP AFQQIQHDRN NSTATAKSMP ASTKSGHSVQ
ATSCSLPPKS PKRLSVPVAA RKAPHPVPII PSKLLCSPPE SPNVSPVIAK RLPFHGHMHK
RSGSFSDSVR DDRAPLCLLK LEQQAFASQE ILNLGSLIRG ELYPPAESYM TMMAPPSPPL
PSSASAGTQD RRNTINETSK PPGSSSGMKT IIGSIRRALH TRHGGQSVSP RAANGQWSPS
MRGKTSALPN NVAFGSDLYR DRKTAATSKR PIRIDILSDE ALQEYRRAVG EVVSPQTARG
PRLEVTEQAM ELEGKKIDRP EPGFDRSMAK SQITMGSQSI VIVDGTGLGE PVMSGAVLEH
SMGLEQPPGF LNAAYTPTTV KAASLRRLSH RLDLAEDQYS LPIYYEEADS GPPNRISRFL
RSSRISDPRR SFSTERFSVS WKRTSPSLRL RKYASFQSGI SRQRSAMARE PSLPPTAATN
PSKLTAGAQV GPTLRRRPGG DLRQMQTVGG LRSRPDSGSF TSGSTYRSSF SDSLMSGQHD
VSRRQTSLIP PNPRYELIQT HSSQMLRRSF EAAIAQFAQI PDDDDGGIES ALLKLEGKWP
GSPTSGEPAG LSNGGSCREP GHVQHDQALG SSDPTTSEVV HRRCQTLLGT DLLYPQARRR
LSPSRPYSDS LAGSESGESY SSIPLLERGL SDESMKKPEP TPRSQNSTLL RSRLSRVSIQ
DTTEVESSHS SIDVVQKTDS LKCIPRGSTQ PVPLSRHSKD QRGRLSGLSS ELSVDIIGSQ
EAFDARLSLD TQSLGDSSFG IPPHPLAHPP SPPMTIQNPR SVASCTTPMD PVLFPAEPLT
PDPSPRNKNT ERNNLRPVNT HQVSGDVLSQ TEMDRQRYNI SKNPEPDHVP FILSCESQIL
AQQLTLVEMA ALSEVDWKDL VDMNWSSGSP STRNWVQFLT EEERRGIDLV VGRFNLMVRW
VVSEIVLVRT LEERASTIVK FIHTAAHAKR ICNYATMLQI AIALSSTDCS RLQKTWALVP
PSERRLLKDM ELLIQPVRNF HDLRMEMETA NLQEGCIPFV GLYVHDLTYN AQKPAQVANP
NGEPLVNFER YRTAARIVKS LLRLIDASTK YKFEPVPGII ERCLWIASLS EDQIQKRSRM
LE
//
