ID Q4WZ36_ASPFU Unreviewed; 944 AA.
AC Q4WZ36;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 2.
DT 24-JAN-2024, entry version 84.
DE SubName: Full=Periplasmic nitrate reductase, putative {ECO:0000313|EMBL:EAL92067.2};
DE EC=1.7.99.4 {ECO:0000313|EMBL:EAL92067.2};
DE Flags: Fragment;
GN ORFNames=AFUA_3G15190 {ECO:0000313|EMBL:EAL92067.2};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL92067.2, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL92067.2, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- COFACTOR:
CC Name=Mo-bis(molybdopterin guanine dinucleotide);
CC Xref=ChEBI:CHEBI:60539; Evidence={ECO:0000256|ARBA:ARBA00001942};
CC -!- PATHWAY: Nitrogen metabolism. {ECO:0000256|ARBA:ARBA00004909}.
CC -!- SIMILARITY: Belongs to the prokaryotic molybdopterin-containing
CC oxidoreductase family. NasA/NapA/NarB subfamily.
CC {ECO:0000256|ARBA:ARBA00008747}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL92067.2}.
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DR EMBL; AAHF01000002; EAL92067.2; -; Genomic_DNA.
DR RefSeq; XP_754105.2; XM_749012.2.
DR AlphaFoldDB; Q4WZ36; -.
DR STRING; 330879.Q4WZ36; -.
DR EnsemblFungi; EAL92067; EAL92067; AFUA_3G15190.
DR GeneID; 3512279; -.
DR KEGG; afm:AFUA_3G15190; -.
DR VEuPathDB; FungiDB:Afu3g15190; -.
DR eggNOG; ENOG502S5VU; Eukaryota.
DR HOGENOM; CLU_000422_13_4_1; -.
DR InParanoid; Q4WZ36; -.
DR OMA; DGPPCCY; -.
DR OrthoDB; 1420095at2759; -.
DR Proteomes; UP000002530; Chromosome 3.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043546; F:molybdopterin cofactor binding; IEA:InterPro.
DR GO; GO:0008940; F:nitrate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR CDD; cd02791; MopB_CT_Nitrate-R-NapA-like; 1.
DR CDD; cd02754; MopB_Nitrate-R-NapA-like; 1.
DR Gene3D; 2.40.40.20; -; 1.
DR Gene3D; 3.40.50.740; -; 1.
DR Gene3D; 2.20.25.90; ADC-like domains; 1.
DR Gene3D; 3.40.228.10; Dimethylsulfoxide Reductase, domain 2; 1.
DR InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR InterPro; IPR041957; CT_Nitrate-R-NapA-like.
DR InterPro; IPR006657; MoPterin_dinucl-bd_dom.
DR InterPro; IPR006656; Mopterin_OxRdtase.
DR PANTHER; PTHR43105:SF9; NITRATE REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15190)-RELATED; 1.
DR PANTHER; PTHR43105; RESPIRATORY NITRATE REDUCTASE; 1.
DR Pfam; PF00384; Molybdopterin; 1.
DR Pfam; PF01568; Molydop_binding; 1.
DR SUPFAM; SSF50692; ADC-like; 1.
DR SUPFAM; SSF53706; Formate dehydrogenase/DMSO reductase, domains 1-3; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Molybdenum {ECO:0000256|ARBA:ARBA00022505};
KW Nitrate assimilation {ECO:0000256|ARBA:ARBA00023063};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:EAL92067.2};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 60..485
FT /note="Molybdopterin oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00384"
FT DOMAIN 613..724
FT /note="Molybdopterin dinucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF01568"
FT NON_TER 944
FT /evidence="ECO:0000313|EMBL:EAL92067.2"
SQ SEQUENCE 944 AA; 106186 MW; 73C362B6A5064493 CRC64;
FCVRRRQTHI QLLTVIRVGH WPVKEHKVVG VRGRITDRVN RGRLGPKGLH GWEAMNHPDR
PKHPLIRRNG KLEPASWDEA MSLIVHQTKD VQKRLTNHGI GFYTTGQLFL EEYYVLAMIG
KAGLNTLHMD GNTRLCTATA AASMRESFGS DGQPGSYTDI DFTDCIFMVG HNMANTQTVL
WSRVLDRLAG PDPPKLVVVD PRESETARHA TVHLAPKGGT NVALLNGLQH LLFENGWLNE
EWVEQHTVGR QELEKTVAKY TPEYVENITG VPADMLKDAA EIIGTSGSLL STALQGVYQS
NQATAAACQI NNINLLLGHI GKPGSGILQM NGQPTAQNNR ETGCNGEYPG FRNFQNEKHM
KEIADVWKID LVQTPHWNQP THIQNMLNYI EDGSIQMFWV SGTNPLVSLP HLYRVRELLT
KPELFLVVQD IFVTETAAIA DVVLPAAQWG EKTGCFTNVD RTMHLSLKAV DPPGEARADL
DIWLDYAKRM GFKNKYGEPL IPFTSPKEVF DEWRKMSFGR PLDCSALTYE KLTGGSGIQW
PCTKEHPYGK DRLFDDGKFF TDTDYCESYG HDLETGTPYT RAQYQAMNPA GRAILKSAQY
KPSLEIPNED YPLLLSTGRN VFHFHTRTKT GRARRLQQAD QEPIVQISVE DAQALHVTEG
EMVVVRSRRG SVELPVRIGG INDGHVFIPF HFGYWDATDG RARAANELTI EQWDPVSKQP
MFKSGAVRIE KCVQKEAERQ TMAVRSVEMR KPDAASSAGD NSNDKKPIRR MELWLGATDQ
ALEMLRDMYV DMIPRLVHDM EIQSGLQVMR RITCEISDQF KPIIERYHES QQYGRRVAEH
LRDSIFPAIG ESKDPYEALA ALQSLDLFLT YIEGHLTALS PASQALWDCD FIEAVKFAQK
GIQRQKGWVS QHIKVKSPQT LLVPSAAAEE LSGEDSRMAG QIRC
//
