GenomeNet

Database: UniProt
Entry: Q4X0C2
LinkDB: Q4X0C2
Original site: Q4X0C2 
ID   DBP9_ASPFU              Reviewed;         649 AA.
AC   Q4X0C2;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   16-OCT-2019, entry version 92.
DE   RecName: Full=ATP-dependent RNA helicase dbp9;
DE            EC=3.6.4.13;
GN   Name=dbp9; ORFNames=AFUA_2G13980;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
RA   Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
RA   Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
RA   Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
RA   Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
RA   Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
RA   Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
RA   Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
RA   Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
RA   Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
RA   Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
RA   Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
RA   Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
RA   Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
RA   White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
RA   Machida M., Hall N., Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX56/DBP9
CC       subfamily. {ECO:0000305}.
DR   EMBL; AAHF01000001; EAL93693.1; -; Genomic_DNA.
DR   RefSeq; XP_755731.1; XM_750638.1.
DR   SMR; Q4X0C2; -.
DR   STRING; 746128.CADAFUBP00002900; -.
DR   PRIDE; Q4X0C2; -.
DR   EnsemblFungi; EAL93693; EAL93693; AFUA_2G13980.
DR   GeneID; 3513203; -.
DR   KEGG; afm:AFUA_2G13980; -.
DR   EuPathDB; FungiDB:Afu2g13980; -.
DR   HOGENOM; HOG000253015; -.
DR   InParanoid; Q4X0C2; -.
DR   KO; K14810; -.
DR   OMA; RYRAQDC; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   Proteomes; UP000002530; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    649       ATP-dependent RNA helicase dbp9.
FT                                /FTId=PRO_0000232335.
FT   DOMAIN       88    266       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      277    514       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     101    108       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        57     85       Q motif.
FT   MOTIF       214    217       DEAD box.
SQ   SEQUENCE   649 AA;  72542 MW;  6103AFA5AEF8F729 CRC64;
     MRKTFQPVVS YNQASFKGPS QRLLELCVVN MKRKLDANDV PSTEVEEEKN TKDADNTDFE
     SLNLDPRLRQ ALIKEQFTKP TPVQSKAIPL ALEGKDILAR AKTGSGKTAA YVLPILQTIL
     QKKAADPSLK ATTGLILVPT RELAEQVQSV IIKFSAFCGK DVRSVNLTQK VSDAVQRTML
     ADYPDLIVST PARVIANLGT SALSLENLTH LVIDEADLVL SYGYDEDINA LAKAIPRGVQ
     TFLMSATLTS EVDTLKGLFC RSPVILKLED KEDEGAGISQ FVVRCAEDEK FLLTYVIFKL
     QLIKGKVIIF VGDIDRCYRL KLFLEQFGIK SCVLNSELPI NSRIHVVQEF NKGVYDIIIA
     ADEQEVMGLR TSSKKSKEAT DGDDEAKDKM GSSEDEDNEP EQSGKSARPE KRRKTSGKAK
     DYGISRGIDF QNVACVLNFD LPTTSKSYTH RIGRTGRAGK AGMALSFVVP ADKFGKHKPT
     SFPTAKHDES VLAKIVKKQA KLGHEVKPYH FEMKQVDAFR YRMTDALRAV TRLAIQEARA
     REIRQELVKS EKLKRHFEEN PEELKQLRHD GELRAARIQP HLKHIPDYLM PSKGRKGISS
     EDVGFVGFRK SGDNRIRKAR EKNRGKGKGR KPSGVRKVDP LKTFNRGRK
//
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