ID Q4X153_ASPFU Unreviewed; 704 AA.
AC Q4X153;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 99.
DE RecName: Full=Origin recognition complex subunit 4 {ECO:0000256|ARBA:ARBA00019083};
GN ORFNames=AFUA_2G11170 {ECO:0000313|EMBL:EAL93412.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL93412.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL93412.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ORC4 family.
CC {ECO:0000256|ARBA:ARBA00005334}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL93412.1}.
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DR EMBL; AAHF01000001; EAL93412.1; -; Genomic_DNA.
DR RefSeq; XP_755450.1; XM_750357.1.
DR AlphaFoldDB; Q4X153; -.
DR SMR; Q4X153; -.
DR STRING; 330879.Q4X153; -.
DR EnsemblFungi; EAL93412; EAL93412; AFUA_2G11170.
DR GeneID; 3513038; -.
DR KEGG; afm:AFUA_2G11170; -.
DR VEuPathDB; FungiDB:Afu2g11170; -.
DR eggNOG; KOG2228; Eukaryota.
DR HOGENOM; CLU_007115_3_0_1; -.
DR InParanoid; Q4X153; -.
DR OMA; MWRQLGR; -.
DR OrthoDB; 230201at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005664; C:nuclear origin of replication recognition complex; IBA:GO_Central.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR016527; ORC4.
DR InterPro; IPR032705; ORC4_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR12087; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR12087:SF0; ORIGIN RECOGNITION COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF14629; ORC4_C; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 283..455
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..28
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..90
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 123..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 77925 MW; 502B29DC3F4D7F93 CRC64;
MTNPRAAKRR RLSDIQPADQ DGDIQMRDDG QNPHSVASSP TGQGASPTTS KTFRQQPEPD
GGEDTAMNGA GDNSASVETP SRNGLRSSGR QRKPPQRYEE EVLNTPSSVK RTRSSVGQSE
RTPRSTRRSR LVPATEEAEE NSPQHQREGL ARTRSKRASA RYAPTEKQDQ EDQPESREQS
LQSPTPDDYQ DGLDDLVSMQ LQQDTTHQDA IEYDDSMVTS DPLPDYAERF LRLVQGGLSE
ELRLLTKVLL KKLNGKQLIP LKGLESEYTK VRQLIEQTVT AGEGNSMLLL GSRGCGKTAI
VETIISSLKR EHMNEFHVVR LNGFLHTDDR LALREMWRQL GRETNTEEEA GKVSTYADTM
AILLALLSHP EELFGPSGNP KAITAAKSII IILDEFDLFA THPRQTLLYN LFDIAQARKA
PIAVLGLTTK VDVTEMLEKR VKSRFSHRYV YVPLPRSFET FSEICFAALN LEDDEKQCFF
DEVAPGKGNT LLEGWRTYLQ ALWADESFNH HLQRIYHQTK SVKEFFASAL LAMTELHYST
YDSSFEIPTP KTFSNQALSC PDPAPLPFST STTISASPSS LPLSLLLAAT RLTALYDPGV
EAGQPQNLAP LALSFPAAYA EYVRLLTSAK TSASVSGATV TPGRVWGRDV AREAWEKLVS
WGLINPVGGG SGTADGRMFR VEVSFEEVVA MAGSGGSLGK WWRE
//