ID Q4X1G9_ASPFU Unreviewed; 1048 AA.
AC Q4X1G9;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 2.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=Nonsense-mediated mRNA decay protein (Nmd5), putative {ECO:0000313|EMBL:EAL93296.2};
GN ORFNames=AFUA_2G10010 {ECO:0000313|EMBL:EAL93296.2};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL93296.2, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL93296.2, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL93296.2}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAHF01000001; EAL93296.2; -; Genomic_DNA.
DR RefSeq; XP_755334.2; XM_750241.2.
DR AlphaFoldDB; Q4X1G9; -.
DR STRING; 330879.Q4X1G9; -.
DR EnsemblFungi; EAL93296; EAL93296; AFUA_2G10010.
DR GeneID; 3513189; -.
DR KEGG; afm:AFUA_2G10010; -.
DR VEuPathDB; FungiDB:Afu2g10010; -.
DR eggNOG; KOG1991; Eukaryota.
DR HOGENOM; CLU_004196_0_0_1; -.
DR InParanoid; Q4X1G9; -.
DR OMA; WVAKTSW; -.
DR OrthoDB; 168511at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF18; D-IMPORTIN 7_RANBP7; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF08506; Cse1; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002530}.
FT DOMAIN 24..99
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REGION 897..920
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..920
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1048 AA; 118958 MW; C471DE3ECA7A6E0A CRC64;
MDVAALRDRI QSTLDANADN RRQAELDLKY AETQPGFINA LLDILQGEQN NAVQLSAGVY
LKNRINRGWS PVEDSPLRAP IPEAEKPGFR ERLIPALAST PPNVRAQLVP LLQKILQHDF
PEQWPGFLDI TLQLLGTNNA NSVYAGLQCL LAICRVYRFK AGEKREEFDK IVEHSFPQLL
NIGLKLVDEE SLEAAEMLRI VVKSYKHAIY FELSPHLQTH QATVDWCTLF LRIIAKQPPA
NSMMESKEER ELNHWWKCKK WSYANLNRLF IRYGNPTTMT KSSTPDYSQY AKTFISTFAP
EILKGYLQEI DKWVSKGQWL SNPALAYTLI FLEECVKPKA MWEHLKPHMD NLIAHFIFPI
MCQSDEDIEL FETDPSEYLH RKLNFYEEVS APDVAATNFL VALTKNRKKQ TFAILTFVNS
VVSKYESAPD DQKLPREKEG ALRMIGSLAS VILGKKSPIA NQVEYFFVRH VFPEFRSPHG
FLRARACDTL EKFEQLDFQD PNNLMIIYRN ILESMTDPEL PVRVEAALAL QPLIRHDIIR
TSMQQNIPQI MQQLLKLANE VDVDALANVM EDFVEVFSAE LTPFAVALSE QLRDTYMRIV
GELLERNAAK GEEDTYGDFL DDKSITALGV LQTIGTLILT LESTPDVLLH LETILMPVIS
ITLENKLYDL YNEVFEIIDS CTFASKSISP TMWQAFELIH KTFKAGAELY LEDMLPALDN
YVAYGSEMLV QNPAYLAAVV GMVEDIFRDE KVGGVDRICG CKLAETVMLN LRGYIDQYIP
LFIELPMRVI EAGEARTKSY RLHLMEMVIN AIYYNPVLSL QVLESKGWTN KFFSTWFSNI
DNFRRVHDKK LSIAAISSLL TLKAGDVPAS VQQGWPRLLQ GVTRLFQTLP AAIKSREDAT
KESDFTYDDE GEEDDEENDW DGEVEWTEGD ELEGAAEGDV PDESAAYLDF LNQEAQKFGS
FADDDDDELD EESLLETPLD KIEPYGMFKH VFMGLQQEQP QLYENLTKIL SPEEQQIIQA
VFHEADAKAM AAANAEAAAA GVQANGAQ
//
