ID Q4X1H0_ASPFU Unreviewed; 1293 AA.
AC Q4X1H0;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 17-APR-2007, sequence version 2.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=DEAD/DEAH box RNA helicase (Ski2), putative {ECO:0000313|EMBL:EAL93295.2};
GN ORFNames=AFUA_2G10000 {ECO:0000313|EMBL:EAL93295.2};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL93295.2, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL93295.2, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000256|ARBA:ARBA00010140}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL93295.2}.
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DR EMBL; AAHF01000001; EAL93295.2; -; Genomic_DNA.
DR RefSeq; XP_755333.2; XM_750240.2.
DR STRING; 330879.Q4X1H0; -.
DR EnsemblFungi; EAL93295; EAL93295; AFUA_2G10000.
DR GeneID; 3513188; -.
DR KEGG; afm:AFUA_2G10000; -.
DR VEuPathDB; FungiDB:Afu2g10000; -.
DR eggNOG; KOG0947; Eukaryota.
DR HOGENOM; CLU_002902_1_4_1; -.
DR InParanoid; Q4X1H0; -.
DR OMA; CGSDITR; -.
DR OrthoDB; 1352at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0055087; C:Ski complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:EnsemblFungi.
DR GO; GO:0070478; P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay; IBA:GO_Central.
DR GO; GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; IEA:EnsemblFungi.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.3380.30; -; 1.
DR Gene3D; 1.20.1500.20; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR048392; MTR4-like_stalk.
DR InterPro; IPR025696; MTR4_beta-barrel.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016438; SKI2-like.
DR InterPro; IPR012961; Ski2/MTR4_C.
DR InterPro; IPR040801; Ski2_N.
DR PANTHER; PTHR12131; ATP-DEPENDENT RNA AND DNA HELICASE; 1.
DR PANTHER; PTHR12131:SF8; HELICASE SKI2W; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF08148; DSHCT; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF21408; MTR4-like_stalk; 1.
DR Pfam; PF13234; MTR4_beta-barrel; 1.
DR Pfam; PF17911; Ski2_N; 1.
DR PIRSF; PIRSF005198; Antiviral_helicase_SKI2; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM01142; DSHCT; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EAL93295.2};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 332..488
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 646..817
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 30..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1293 AA; 144832 MW; 73E9438E4C8BD9B6 CRC64;
MAETVASILV DLNLKTENLS GSAFDAQLAE EEKGSYRHRG PRQRPRQSAS DLKDELEKEI
LTPSPRFSPE WLNRLQKRWD VPVNYTDLYE IAPTQTRTIV RFTREGLEGR VTGYHEVTVP
AAAANAKNST SLLRRPAGRA DFVRGAAGFF PFAPGGLDGV EAIAEMESEA QAAERSKTGG
KQSGLDRIIN FGAEGGLLEI APGCSRGLQF EATKTKETAE GDEEVEHALQ QEESDLHVER
DEDVMSDVEG GVKIGEDDEL SGEEDIDSLL PVEFPALEPR APLLSGVKQR QGGKEWAHVV
DVNKHISNFH ELVPDMAREW PFELDTFQKE AVYHLENGDS VFVAAHTSAG KTVVAEYAIA
LASKHMTKAI YTSPIKALSN QKFRDFRTEF DDVGILTGDV QINPEASCLI MTTEILRSML
YRGADLIRDV EFVIFDEVHY VNDLERGVVW EEVIIMLPEH VTLILLSATV PNTYEFASWV
GRTKKKDIYV ISTAKRPVPL EHYLWAGKDK YKIVDSNKRF LETGWKEADN VISGRDKIKA
QKAAEAQAQS QAQRGGQQGR GRGQPTGRGA PRGNAQRGGA PRGRGQPANR GTGNIARTGR
GGGRTTAAQD KTIWVQLVGH LRKENLLPGC IFVFSKKRCE ENADSLSNQD FCNASEKSLI
HMFIEKSLTR LKPEDRILPQ ILRLRELLSR GIAVHHGGLL PIMKEIVEIL FAKSLVKILF
ATETFAMGLN LPTRTVVFSG FRKHDGRGFR DLLPGEYTQM AGRAGRRGLD TVGYVIIVSA
GRDEAPPAGA LRKMILGDPT KLRSQFRLTY NMILNLLRVE ALKIEEMIKR SFSENATQAL
LPEHEKQVQL SEASLAKIKR EPCDICDIDL VACHDAAIEY EKLTSELHVG LLASPVGKRL
FMPKRLVVYR KDGFRTAGII VREGVGGGAT PNIQVLEIGK LSHRRHPSDI LPFLPRFRHL
LHPLPTRAAD MTLKVCKIPL SDLECVTNTI VKVGGPTWYL NIKKEAIKFA DKELSKLCAS
WTSPIWDEMD WARIKELQVR DILEKRQAQA AITQSCRCLQ CPSFMKHFEM QHDEWQVKEN
ISQLKQLMSD QNLQLLPDYE QRIQVLRDLG FIDEQSRVQL KGKVACEIHS ADELVLTELI
LENVLAEYEP EEIVALLSAF VFQEKTENVP TLTPRLEKGK EAIIRIAEKV NDLQIQYQVI
QSSEDSNDFA SQPRFGLAEV VYEWAKGMSF NRITDLTDVM EGTIVRTITR LDETCREVRN
AAKLVGDPTL YAKMQHAQEL IKRDVIFAAS LYM
//
