ID Q4X1R5_ASPFU Unreviewed; 801 AA.
AC Q4X1R5;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Vacuolar transporter chaperone (Vtc4), putative {ECO:0000313|EMBL:EAL93200.1};
GN ORFNames=AFUA_2G09040 {ECO:0000313|EMBL:EAL93200.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL93200.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL93200.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL93200.1}.
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DR EMBL; AAHF01000001; EAL93200.1; -; Genomic_DNA.
DR RefSeq; XP_755238.1; XM_750145.1.
DR AlphaFoldDB; Q4X1R5; -.
DR STRING; 330879.Q4X1R5; -.
DR EnsemblFungi; EAL93200; EAL93200; AFUA_2G09040.
DR GeneID; 3512868; -.
DR KEGG; afm:AFUA_2G09040; -.
DR eggNOG; KOG1161; Eukaryota.
DR eggNOG; KOG4580; Eukaryota.
DR HOGENOM; CLU_009308_0_0_1; -.
DR InParanoid; Q4X1R5; -.
DR OMA; AGGKQQN; -.
DR OrthoDB; 11387at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0000329; C:fungal-type vacuole membrane; IBA:GO_Central.
DR GO; GO:0033254; C:vacuolar transporter chaperone complex; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IEA:EnsemblFungi.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IEA:EnsemblFungi.
DR GO; GO:0008976; F:polyphosphate kinase activity; IEA:EnsemblFungi.
DR GO; GO:0016237; P:microautophagy; IBA:GO_Central.
DR GO; GO:0006799; P:polyphosphate biosynthetic process; IEA:EnsemblFungi.
DR GO; GO:0006797; P:polyphosphate metabolic process; IBA:GO_Central.
DR GO; GO:0007034; P:vacuolar transport; IBA:GO_Central.
DR GO; GO:0042144; P:vacuole fusion, non-autophagic; IBA:GO_Central.
DR CDD; cd07751; PolyPPase_VTC4_like; 1.
DR CDD; cd14480; SPX_VTC2_like; 1.
DR Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR InterPro; IPR003807; DUF202.
DR InterPro; IPR004331; SPX_dom.
DR InterPro; IPR018966; VTC_domain.
DR InterPro; IPR042267; VTC_sf.
DR PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR PANTHER; PTHR46140:SF1; VACUOLAR TRANSPORTER CHAPERONE 4; 1.
DR Pfam; PF02656; DUF202; 1.
DR Pfam; PF09359; VTC; 1.
DR PROSITE; PS51382; SPX; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 686..706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 713..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..774
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..159
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT REGION 508..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 92357 MW; B2A6D66035556F34 CRC64;
MIKEYYWYYI AYEDLKKALK TGYVSEPTSE NPKPDRKPWT EDHEKRFVSL LESELDKVFN
FQKLKSEEIV RRIQASEKDV ADVVSRLDNA NNSRRQSLRT SQPPPSDEDF LLLEQVLSDI
IADVHDLAKF TQLNYTGFQK IIKKHDKQTG WHLKPVFAAR LKAKPFFKDN YDAFVVKLSK
LYDLVRTKGN PVKGDSAAGG SQQNFVRQTT KYWVHPDNIT ELKLIILKHL PVLVFNPNKE
FEEKDAAISS IYFDNTNTWE LYEGRLKKTE GAEAIRLRWY GGMESDQIFV ERKTHREDWT
GEKSVKARFS LKEKHVNAYL SGRMTVESIF EKMRKEGKKS EQEIADLEQL AREIQYRVIT
RRLEPVTRTF YHRTAFQLPG DARVRISLDT ELTMIREDNL DGRQRSGNNW RRMDIGVDWP
FSQLPPQDVE RFPYAVLEVK LQTQAGQEPP KWIRELTASH LVEAVPKFSK FIHGTATLFP
DRIHLLPFWM PQMDVDIRKP ATRRFGITRP LASTSLSANE TPEDDESDED ESDEAQARTR
AATRDAQHSV VDQSDLFEDN DGNALDIEER IAAQPLPGDE DYPLYDSDEE SNYSDELEEA
RRIGGGYYYQ KLVEYYIHRM GHALINGLKA IAPGPRPTDM PEPEQNGITV MGNKRTIKRF
VAPKGKRIHV PVRVEPKVYF AAERTFLSWL EFSILLGTIA ATLLNFGNDY ITFVSSWAFT
ILAAVALIYS LMLYIWRVDK IRKRRDVKRV YYEKWGPTVV GLGLVVIMLV NFGLRVRQTG
FAARDGDQGF GHGRGSAGGE L
//
