GenomeNet

Database: UniProt
Entry: Q4X1W8
LinkDB: Q4X1W8
Original site: Q4X1W8 
ID   SET9_ASPFU              Reviewed;         622 AA.
AC   Q4X1W8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   10-APR-2019, entry version 84.
DE   RecName: Full=Histone-lysine N-methyltransferase set9;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain protein 9;
GN   Name=set9; ORFNames=AFUA_2G08510;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S.,
RA   Arroyo J., Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W.,
RA   Bowyer P., Chen D., Collins M., Coulsen R., Davies R., Dyer P.S.,
RA   Farman M.L., Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R.,
RA   Fosker N., Fraser A., Garcia J.L., Garcia M.J., Goble A.,
RA   Goldman G.H., Gomi K., Griffith-Jones S., Gwilliam R., Haas B.J.,
RA   Haas H., Harris D.E., Horiuchi H., Huang J., Humphray S., Jimenez J.,
RA   Keller N., Khouri H., Kitamoto K., Kobayashi T., Konzack S.,
RA   Kulkarni R., Kumagai T., Lafton A., Latge J.-P., Li W., Lord A.,
RA   Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y., Molina M.,
RA   Monod M., Mouyna I., Mulligan S., Murphy L.D., O'Neil S., Paulsen I.,
RA   Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA   Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M.,
RA   Sanchez-Ferrero J.C., Saunders D., Seeger K., Squares R., Squares S.,
RA   Takeuchi M., Tekaia F., Turner G., Vazquez de Aldana C.R., Weidman J.,
RA   White O., Woodward J.R., Yu J.-H., Fraser C.M., Galagan J.E., Asai K.,
RA   Machida M., Hall N., Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Histone methyltransferase that specifically methylates
CC       'Lys-20' of histone H4. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00900};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00900}.
DR   EMBL; AAHF01000001; EAL93147.1; -; Genomic_DNA.
DR   RefSeq; XP_755185.1; XM_750092.1.
DR   ProteinModelPortal; Q4X1W8; -.
DR   SMR; Q4X1W8; -.
DR   STRING; 746128.CADAFUBP00002388; -.
DR   EnsemblFungi; EAL93147; EAL93147; AFUA_2G08510.
DR   GeneID; 3513303; -.
DR   KEGG; afm:AFUA_2G08510; -.
DR   EuPathDB; FungiDB:Afu2g08510; -.
DR   HOGENOM; HOG000214006; -.
DR   InParanoid; Q4X1W8; -.
DR   KO; K11429; -.
DR   OMA; IYLPDCP; -.
DR   OrthoDB; 953612at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   Proteomes; UP000002530; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:InterPro.
DR   InterPro; IPR025783; Hist-Lys_N-MeTrfase_SET9.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51567; SAM_MT43_SUVAR420_1; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Chromatin regulator; Chromosome; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    622       Histone-lysine N-methyltransferase set9.
FT                                /FTId=PRO_0000281798.
FT   DOMAIN      120    234       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   622 AA;  69939 MW;  6A46811359F7B0A4 CRC64;
     MPSAKKRDSP SVDRRDRLTL AKLASYDDIA TDALVDRAYF WTNTRKNRTK YNPMRGIVDD
     DVARVLLHDV IVAKDLAKAE RELLAMSGLK KFMARLPNNR EKDWFRRHLR KYIQMYLPDS
     PFEITTTNRY TITEYEAAVC ARKFIKQGQE IKYLSGTLVP MTREEERDLD LKRKDFSIVM
     SSRKKTPSFF LGPARFANHD CNANGKLVTR GSEGMQVVAT RDIYIGEEIT VSYGDDYFGI
     DNCECLCLTC ERLVRNGWAP HVPSEPQSKA STPALNDDTL STDSHVSSKK RKFAPDSDIE
     TSAPSTPCKR GKFVRQSSKL KSEVSFLEVA TSIEQPAGPS PVCNGSDMGA LGNSTVESDN
     DKAVDPALPS PPADSPPSTA ANESERSSTS TTATSVCDAA VKIKVEETIE QSAEKVSALS
     EANVELPTTS LRSGSTEGDT KLELSDQPST LKQGSIGSNR KERRKSRGKP LVVESVEAER
     QLVRVPGDYT KTSKLLAQTY DRWVDCHTCN AWFVQHDSYL TRRECPRCER HSMLYGYRWP
     KTDKEGPSDD EERVMDHRTV HRFLYPEEEA LISRKDRGVS FGVTPTPELS EPRTETEGSE
     GCEDRRTTRA SRRRTRSLRM TM
//
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