ID Q4X272_ASPFU Unreviewed; 981 AA.
AC Q4X272;
DT 05-JUL-2005, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2005, sequence version 1.
DT 24-JAN-2024, entry version 81.
DE SubName: Full=PX domain protein {ECO:0000313|EMBL:EAL93043.1};
GN ORFNames=AFUA_2G07450 {ECO:0000313|EMBL:EAL93043.1};
OS Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 /
OS Af293) (Neosartorya fumigata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879 {ECO:0000313|EMBL:EAL93043.1, ECO:0000313|Proteomes:UP000002530};
RN [1] {ECO:0000313|EMBL:EAL93043.1, ECO:0000313|Proteomes:UP000002530}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100
RC {ECO:0000313|Proteomes:UP000002530};
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.,
RA Fedorova N., Fedorova N., Feldblyum T.V., Fischer R., Fosker N., Fraser A.,
RA Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B., Haas H., Harris D., Horiuchi H.,
RA Huang J., Humphray S., Jimenez J., Keller N., Khouri H., Kitamoto K.,
RA Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafon A., Latge J.P.,
RA Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L., Mohamoud Y.,
RA Molina M., Monod M., Mouyna I., Mulligan S., Murphy L., O'Neil S.,
RA Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L., Quail M.A.,
RA Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U., Renauld H.,
RA Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M., Ronning C.M.,
RA Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C., Saunders D.,
RA Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F., Turner G.,
RA Vazquez de Aldana C.R., Weidman J., White O., Woodward J., Yu J.H.,
RA Fraser C., Galagan J.E., Asai K., Machida M., Hall N., Barrell B.,
RA Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL93043.1}.
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DR EMBL; AAHF01000001; EAL93043.1; -; Genomic_DNA.
DR RefSeq; XP_755081.1; XM_749988.1.
DR AlphaFoldDB; Q4X272; -.
DR EnsemblFungi; EAL93043; EAL93043; AFUA_2G07450.
DR GeneID; 3513761; -.
DR KEGG; afm:AFUA_2G07450; -.
DR eggNOG; ENOG502RM76; Eukaryota.
DR HOGENOM; CLU_007315_0_0_1; -.
DR InParanoid; Q4X272; -.
DR OMA; INGWIIH; -.
DR OrthoDB; 2727031at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IBA:GO_Central.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775:SF47; MEIOTICALLY UP-REGULATED GENE 122 PROTEIN; 1.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF02194; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002530};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 170..330
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT REGION 354..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 683..820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 683..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..820
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 981 AA; 106733 MW; D38D4905BA8E9C3A CRC64;
MDDSIDRPLP SPLTETCSDV RDATDCLLTS RHDESDQRSD LIPTITPSKG PVENMLHFLS
SADNLTLAWI VASLAIVTYV LLGRIGLLLI GMVAGVVLHA SWEAADTGLW KDPTGTSSIY
RRKELSMNIA NRLLELSSRK PSEPKSNNGG IIAEAAEGMS EPELDFSGFP PKTAAALRSL
TDAVIKDYVK YVRITYVSAR SDRIQVTDAF LEFLTNSSSM VIVLLNELSA AFQHVEGRLT
PEDAVKRYLD LHPESSLANI LSEQQQRMKL KMVADDILSS FLEPGVYACS VLRDFLREIL
AGVVLESAIS NLSRSETING WIIHLLREGE SELLNAIDAG VEGAKEQVVA VEGANEENKP
TAVPSSESDM EGKPAGHSDT YGILPTTKVI EVPIYPPGGT TVQTQDLQPQ TARLCSPEDM
LSSDAQSTML PHHSPVGIQD KEATIHTPKV KDAAEIQNDY DSTKIESTEH YPPVQPTDPC
MAPPASRLPD FQSKKSPATT LHHASVSVEE LSEASEKALI RSKPTSSYLI QIEPAATRRT
GWMIFRNYAD FESLHGTLGT IARLNKIQDF TESHPVLPPW KGQTKGALVR NLERYLKDAL
HYEALADCER MKRFLEKDER LDPGASDAPA KSGFPFATSV ALENMGKGML GVLTNAPKGV
AEGGKAVIGG VTGVFGGANG KKTSFNSKGY QGNHGRSLST RSTSQMNYGS AVSDGVDRPK
RPVSENNKTE RYSLAVVPTP ESSGSQEDPP SPGSGNVVDS TIPRFGDLAS SESKLESDRL
QGSLSDSDGG ADLASRIKPK EEQKASDGQS TVRRRESPIS QEETQIAVEL IFAVINELYS
LSSAWNIRRT LLNAAKSYIL RPGSPSLETI RSLLQESMID ANISDASIAS YLTKLRENVL
PTKEELESWP QPPSSVEKER MREIARKTLV LKGLPQALTS VMGAAASRES LERVFDCLQV
EMIARGFVYS ILLQALRALT F
//
