ID Q503Q6_DANRE Unreviewed; 70 AA.
AC Q503Q6; A0A8M1NVS5;
DT 07-JUN-2005, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2005, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE RecName: Full=Guanine nucleotide-binding protein subunit gamma {ECO:0000256|RuleBase:RU004973};
GN Name=gng8 {ECO:0000313|Ensembl:ENSDARP00000063088,
GN ECO:0000313|RefSeq:NP_001171214.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050522-312};
GN Synonyms=zgc:110316 {ECO:0000313|RefSeq:NP_001171214.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH95223.1};
RN [1] {ECO:0000313|EMBL:AAH95223.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAH95223.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001171214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RX PubMed=19786091;
RA Mulligan T., Blaser H., Raz E., Farber S.A.;
RT "Prenylation-deficient G protein gamma subunits disrupt GPCR signaling in
RT the zebrafish.";
RL Cell. Signal. 22:221-233(2010).
RN [3] {ECO:0000313|Ensembl:ENSDARP00000063088}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063088};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001171214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RX PubMed=23734103;
RA deCarvalho T.N., Akitake C.M., Thisse C., Thisse B., Halpern M.E.;
RT "Aversive cues fail to activate fos expression in the asymmetric olfactory-
RT habenula pathway of zebrafish.";
RL Front. Neural Circuits 7:98-98(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000063088, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000063088};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [6] {ECO:0000313|RefSeq:NP_001171214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RX PubMed=24327734; DOI=10.1073/pnas.1319566110;
RA Hong E., Santhakumar K., Akitake C.A., Ahn S.J., Thisse C., Thisse B.,
RA Wyart C., Mangin J.M., Halpern M.E.;
RT "Cholinergic left-right asymmetry in the habenulo-interpeduncular
RT pathway.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:21171-21176(2013).
RN [7] {ECO:0000313|RefSeq:NP_001171214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RX PubMed=24753112;
RA deCarvalho T.N., Subedi A., Rock J., Harfe B.D., Thisse C., Thisse B.,
RA Halpern M.E., Hong E.;
RT "Neurotransmitter map of the asymmetric dorsal habenular nuclei of
RT zebrafish.";
RL Genesis 52:636-655(2014).
RN [8] {ECO:0000313|RefSeq:NP_001171214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RX PubMed=24559675;
RA Ferreira T., Wilson S.R., Choi Y.G., Risso D., Dudoit S., Speed T.P.,
RA Ngai J.;
RT "Silencing of odorant receptor genes by G protein betagamma signaling
RT ensures the expression of one odorant receptor per olfactory sensory
RT neuron.";
RL Neuron 81:847-859(2014).
RN [9] {ECO:0000313|RefSeq:NP_001171214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RX PubMed=26699284;
RA Tallafuss A., Kelly M., Gay L., Gibson D., Batzel P., Karfilis K.V.,
RA Eisen J., Stankunas K., Postlethwait J.H., Washbourne P.;
RT "Transcriptomes of post-mitotic neurons identify the usage of alternative
RT pathways during adult and embryonic neuronal differentiation.";
RL BMC Genomics 16:1100-1100(2015).
RN [10] {ECO:0000313|RefSeq:NP_001171214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [11] {ECO:0000313|RefSeq:NP_001171214.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RX PubMed=27773705;
RA Gao S., Liu S., Yao J., Li N., Yuan Z., Zhou T., Li Q., Liu Z.;
RT "Genomic organization and evolution of olfactory receptors and trace amine-
RT associated receptors in channel catfish, Ictalurus punctatus.";
RL Biochim Biophys Acta Gen Subj 1861:644-651(2017).
RN [12] {ECO:0000313|RefSeq:NP_001171214.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001171214.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC as a modulator or transducer in various transmembrane signaling
CC systems. The beta and gamma chains are required for the GTPase
CC activity, for replacement of GDP by GTP, and for G protein-effector
CC interaction. {ECO:0000256|RuleBase:RU004973}.
CC -!- SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma.
CC {ECO:0000256|RuleBase:RU004973}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU004973};
CC Lipid-anchor {ECO:0000256|RuleBase:RU004973}; Cytoplasmic side
CC {ECO:0000256|RuleBase:RU004973}.
CC -!- SIMILARITY: Belongs to the G protein gamma family.
CC {ECO:0000256|ARBA:ARBA00007431, ECO:0000256|RuleBase:RU004973}.
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DR EMBL; CR450711; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC095223; AAH95223.1; -; mRNA.
DR RefSeq; NP_001171214.1; NM_001177743.2.
DR STRING; 7955.ENSDARP00000063088; -.
DR PaxDb; 7955-ENSDARP00000063088; -.
DR Ensembl; ENSDART00000063089.7; ENSDARP00000063088.5; ENSDARG00000042970.7.
DR GeneID; 553609; -.
DR KEGG; dre:553609; -.
DR AGR; ZFIN:ZDB-GENE-050522-312; -.
DR CTD; 94235; -.
DR ZFIN; ZDB-GENE-050522-312; gng8.
DR eggNOG; KOG4119; Eukaryota.
DR HOGENOM; CLU_168377_0_1_1; -.
DR OMA; LMSYCES; -.
DR OrthoDB; 2872810at2759; -.
DR TreeFam; TF319909; -.
DR Reactome; R-DRE-1296041; Activation of G protein gated Potassium channels.
DR Reactome; R-DRE-202040; G-protein activation.
DR Reactome; R-DRE-381676; Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
DR Reactome; R-DRE-392170; ADP signalling through P2Y purinoceptor 12.
DR Reactome; R-DRE-392451; G beta:gamma signalling through PI3Kgamma.
DR Reactome; R-DRE-392851; Prostacyclin signalling through prostacyclin receptor.
DR Reactome; R-DRE-400042; Adrenaline,noradrenaline inhibits insulin secretion.
DR Reactome; R-DRE-4086398; Ca2+ pathway.
DR Reactome; R-DRE-416476; G alpha (q) signalling events.
DR Reactome; R-DRE-416482; G alpha (12/13) signalling events.
DR Reactome; R-DRE-418217; G beta:gamma signalling through PLC beta.
DR Reactome; R-DRE-418555; G alpha (s) signalling events.
DR Reactome; R-DRE-418592; ADP signalling through P2Y purinoceptor 1.
DR Reactome; R-DRE-418594; G alpha (i) signalling events.
DR Reactome; R-DRE-418597; G alpha (z) signalling events.
DR Reactome; R-DRE-420092; Glucagon-type ligand receptors.
DR Reactome; R-DRE-428930; Thromboxane signalling through TP receptor.
DR Reactome; R-DRE-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-DRE-456926; Thrombin signalling through proteinase activated receptors (PARs).
DR Reactome; R-DRE-500657; Presynaptic function of Kainate receptors.
DR Reactome; R-DRE-6814122; Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.
DR Reactome; R-DRE-8964315; G beta:gamma signalling through BTK.
DR Reactome; R-DRE-8964616; G beta:gamma signalling through CDC42.
DR Reactome; R-DRE-9009391; Extra-nuclear estrogen signaling.
DR Reactome; R-DRE-9634597; GPER1 signaling.
DR Reactome; R-DRE-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000042970; Expressed in habenula and 7 other cell types or tissues.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0031681; F:G-protein beta-subunit binding; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00068; GGL; 1.
DR Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR InterPro; IPR015898; G-protein_gamma-like_dom.
DR InterPro; IPR036284; GGL_sf.
DR InterPro; IPR001770; Gprotein-gamma.
DR PANTHER; PTHR13809:SF19; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I)_G(S)_G(O) SUBUNIT GAMMA-8; 1.
DR PANTHER; PTHR13809; GUANINE NUCLEOTIDE-BINDING PROTEIN GAMMA SUBUNIT; 1.
DR Pfam; PF00631; G-gamma; 1.
DR PRINTS; PR00321; GPROTEING.
DR SMART; SM01224; G_gamma; 1.
DR SMART; SM00224; GGL; 1.
DR SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR PROSITE; PS50058; G_PROTEIN_GAMMA; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU004973};
KW Lipoprotein {ECO:0000256|RuleBase:RU004973};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004973};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|RuleBase:RU004973}.
FT DOMAIN 4..70
FT /note="G protein gamma"
FT /evidence="ECO:0000259|PROSITE:PS50058"
SQ SEQUENCE 70 AA; 7870 MW; D1EB19515730E8B7 CRC64;
MSNNMAKIAD ARKTVEQLKL EVNIDRMMVS KAAAELMAYC ESHAKEDPLV TPVPSSENPF
REKKIFCTVL
//