ID Q52Z74_CHICK Unreviewed; 348 AA.
AC Q52Z74;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 24-JAN-2024, entry version 140.
DE SubName: Full=CD1.2 antigen {ECO:0000313|EMBL:AAX49406.1};
DE SubName: Full=T-cell surface glycoprotein CD1A2 antigen {ECO:0000313|EMBL:BAF63012.1};
GN Name=CD1.2 {ECO:0000313|EMBL:AAX49406.1};
GN Synonyms=CD1A2 {ECO:0000313|EMBL:BAF63012.1};
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000313|EMBL:AAX49406.1};
RN [1] {ECO:0000313|EMBL:AAX49406.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Spleen {ECO:0000313|EMBL:AAX49406.1};
RX PubMed=15939887; DOI=10.1073/pnas.0409213102;
RA Salomonsen J., Sorensen M.R., Marston D.A., Rogers S.L., Collen T.,
RA van Hateren A., Smith A.L., Beal R.K., Skjodt K., Kaufman J.;
RT "Two CD1 genes map to the chicken MHC, indicating that CD1 genes are
RT ancient and likely to have been present in the primordial MHC.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:8668-8673(2005).
RN [2] {ECO:0000313|EMBL:BAF63012.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17513765; DOI=10.4049/jimmunol.178.11.7162;
RA Shiina T., Briles W.E., Goto R.M., Hosomichi K., Yanagiya K., Shimizu S.,
RA Inoko H., Miller M.M.;
RT "Extended gene map reveals tripartite motif, C-type lectin, and Ig
RT superfamily type genes within a subregion of the chicken MHC-B affecting
RT infectious disease.";
RL J. Immunol. 178:7162-7172(2007).
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DR EMBL; AY849318; AAX49404.1; -; Genomic_DNA.
DR EMBL; AY849320; AAX49406.1; -; mRNA.
DR EMBL; AB268588; BAF63012.1; -; Genomic_DNA.
DR RefSeq; NP_001019753.1; NM_001024582.1.
DR AlphaFoldDB; Q52Z74; -.
DR SMR; Q52Z74; -.
DR STRING; 9031.ENSGALP00000044711; -.
DR PaxDb; 9031-ENSGALP00000042318; -.
DR GeneID; 425802; -.
DR KEGG; gga:425802; -.
DR CTD; 910; -.
DR VEuPathDB; HostDB:geneid_425802; -.
DR eggNOG; ENOG502SJH6; Eukaryota.
DR HOGENOM; CLU_047501_9_0_1; -.
DR InParanoid; Q52Z74; -.
DR OMA; THCEFPR; -.
DR OrthoDB; 3840485at2759; -.
DR Reactome; R-GGA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Bgee; ENSGALG00000043052; Expressed in granulocyte and 11 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0030883; F:endogenous lipid antigen binding; IBA:GO_Central.
DR GO; GO:0030884; F:exogenous lipid antigen binding; IBA:GO_Central.
DR GO; GO:0071723; F:lipopeptide binding; IBA:GO_Central.
DR GO; GO:0048006; P:antigen processing and presentation, endogenous lipid antigen via MHC class Ib; IBA:GO_Central.
DR GO; GO:0048007; P:antigen processing and presentation, exogenous lipid antigen via MHC class Ib; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IBA:GO_Central.
DR CDD; cd21029; IgC1_CD1; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR PANTHER; PTHR16675:SF160; T-CELL SURFACE GLYCOPROTEIN CD1A; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF16497; MHC_I_3; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..348
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014309509"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 209..314
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 348 AA; 39353 MW; DBA2B348F80F2E5D CRC64;
MWPHCLFLFL LLHKTWAEAE TSCPPPEESQ FFQLFYTLLL GNVSSTELTG MALLADVPIM
VLDPHTWNLN ICRPWVQEIT AETEVKKILS FSMVGIRNTI RFMHEMTAKA GLDYPRVFQI
HTGCKLYTNG TRWSFVNIGE GGRDLVTYEL SRERWVPQRS TLLAKVMSNT LTDLRAVSGF
LEHVFSSSFP NYILMLHEEG RTDLERRVPP MAVVFARTAG QVQLLLVCRV TSFYPRPIAV
TWLRDGREVP PSPALSTGTV LPNADLTYQL RSTLLVSPQD GHSYACRVQH CSLGDRSLLV
PWENPSASST VGITITILLL AAIITGGIWW WRRRKHAGSG TDFRTFLI
//
