ID Q54B17_DICDI Unreviewed; 1403 AA.
AC Q54B17;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Condensin-2 complex subunit D3 {ECO:0000313|EMBL:EAL60491.1};
GN ORFNames=DDB_G0293984 {ECO:0000313|EMBL:EAL60491.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL60491.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL60491.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL60491.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Regulatory subunit of the condensin complex, a complex
CC required for conversion of interphase chromatin into mitotic-like
CC condense chromosomes. The condensin complex probably introduces
CC positive supercoils into relaxed DNA in the presence of type I
CC topoisomerases and converts nicked DNA into positive knotted forms in
CC the presence of type II topoisomerases.
CC {ECO:0000256|PIRNR:PIRNR017127}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CND1 (condensin subunit 1) family.
CC {ECO:0000256|ARBA:ARBA00009606, ECO:0000256|PIRNR:PIRNR017127}.
CC -!- SIMILARITY: Belongs to the pro/parathymosin family.
CC {ECO:0000256|ARBA:ARBA00008032}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL60491.1}.
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DR EMBL; AAFI02000224; EAL60491.1; -; Genomic_DNA.
DR RefSeq; XP_628899.1; XM_628897.1.
DR AlphaFoldDB; Q54B17; -.
DR SMR; Q54B17; -.
DR STRING; 44689.Q54B17; -.
DR PaxDb; 44689-DDB0304964; -.
DR GeneID; 8629515; -.
DR KEGG; ddi:DDB_G0293984; -.
DR dictyBase; DDB_G0293984; ncapD2.
DR eggNOG; KOG0414; Eukaryota.
DR HOGENOM; CLU_001867_2_1_1; -.
DR InParanoid; Q54B17; -.
DR OMA; CPLEKLW; -.
DR PhylomeDB; Q54B17; -.
DR Reactome; R-DDI-2514853; Condensation of Prometaphase Chromosomes.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0000779; C:condensed chromosome, centromeric region; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0010032; P:meiotic chromosome condensation; IBA:GO_Central.
DR GO; GO:0007076; P:mitotic chromosome condensation; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR026971; CND1/NCAPD3.
DR InterPro; IPR032682; Cnd1_C.
DR InterPro; IPR007673; Condensin_cplx_su1.
DR InterPro; IPR024324; Condensin_cplx_su1_N.
DR InterPro; IPR004931; Pro/parathymosin.
DR PANTHER; PTHR14222; CONDENSIN; 1.
DR PANTHER; PTHR14222:SF2; CONDENSIN COMPLEX SUBUNIT 1; 1.
DR Pfam; PF12717; Cnd1; 1.
DR Pfam; PF12922; Cnd1_N; 1.
DR Pfam; PF03247; Prothymosin; 1.
DR PIRSF; PIRSF017127; Condensin_D2; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR017127};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|PIRNR:PIRNR017127}; Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067,
KW ECO:0000256|PIRNR:PIRNR017127};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|PIRNR:PIRNR017127};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 37..164
FT /note="Condensin complex subunit 1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12922"
FT DOMAIN 988..1155
FT /note="Condensin complex subunit 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12717"
FT REGION 49..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 301..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 464..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1234..1403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..498
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1234..1257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1299
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1357
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1373
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1403 AA; 161449 MW; 5F3F471302745C9E CRC64;
MLEFQIPIHF EDISLSSSDK YSIKKIIDKF IKNVYIFLEH YISYQHSSST TKESSKSTSE
NNNETASITS KKKSTKKKNS SVLDTWEQEE QKEAILTSII NCLELNLSTL WRLDYPEEEF
INLLSKIIYA MIEQPANLRS KGVKKLIFEV LSILILRYNH SFNFTSKIIH LLHNHESLPS
HCADLYEFIY DYQQQQQKHQ QQQQQQNIYS QSTNQQQKNQ TTFLISDIIR EIGKQKEQRD
TSGFKNLAKF LSELTDRLPK IVLPFVSLLL AHLDSESYLM RNAVTESIGF LIGKALNKVE
SNNKDKKSEQ EEEEEVENQK KNESDQSELL HILFERCRDI NGYCRSSVLK TLSLLVNNNW
VPKESYIQLT KIAIERVSDK NSLVRKRAIL LLSDILESNP YSPHLPTLLF KDKKEKLASF
IKLSFYNLKK KKELLKKSKK LKNNNNNNNE DDLLNSQQVP DDNMEFEQQQ QQQKEEEEKK
EKEEEDGEEE EEEEEITEKQ IFEDIKLNKE QFFDLISMLV PFSGIKEFSP HRLPLYLEHL
NKYLDSSCKF IKIINSTIDT MCQLMGSVNP SDILESVHFI QVAHKYQIDK SKEAITKMLA
LIWNKEQSIK ESTIRSFHEL LIKDTREKVK STLKSSYYIA KNLIDLTTTA TLGEITSLEE
LMIEFTKKDL IDQDIIKALW DIFSGKVVNF NKQDSRGALI ILSMISNNNS SVVKDKVNLL
VSIGLEEQDD EFLPRYTCIT LQKLRSKGLK ETDQILPRFK NNQSLFERLI YHICSTTTTT
TTTNDNIDND IKNSKWFMFA EQVINTIYIL AEQPDLISSE IIKKLSDQVL DENGETNQYC
LSKLIFILGH IAIKQLVYVE EIQSEIKRIQ YEQSKQSKNN NNNNKKKTDI EKELGTDQAE
AEAESEAIQI QAESDILSEN NLIGKYSQLV VSICYNYNEI FSNEQFPNQL LQTSAVLTLS
KFMCVDSNFC ESNLQLLFTL LEKSSIEVIR SNIIIGLGDL AFRFPNLVEP WTSKIYSRLR
DPNADARKNS LMVLTHLILN DMIKVKGQIS EMAICLEDSD IRISNIAKLF FSTLASKGNN
LYNSLPDIIG KITPASTVTS NLNNISKDSI KNILKYLFSF IEKDKQSETL IDKLLQRFKT
SKSISESQNI SFCLQLLNYN DKSLKKLIEH FKLYQDKLND NEIYNNLMIS ISKTKKQPNL
TKTSEIKQLV DEIEKKINTA RSQLTLGETV QLVQETDGNS SGTSSTTTTS QSIQKPPLKP
SKKAPAKKRA PSRKKYQSSE EEESEESSEE EDEESGDDED RMIITPKKPI SKPMVPSRKR
QPVQKKKSSE SEQSSESDQS SEISDIDRMD ITPKKPPKKP QPKQSKKKPA SRLKKAISQS
ESESESDIDS ESSNSSSFDN ISE
//
