ID Q54BU8_DICDI Unreviewed; 1623 AA.
AC Q54BU8;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Breast cancer type 2 susceptibility protein homolog {ECO:0008006|Google:ProtNLM};
GN ORFNames=DDB_G0293414 {ECO:0000313|EMBL:EAL60741.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL60741.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL60741.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL60741.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL60741.1}.
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DR EMBL; AAFI02000207; EAL60741.1; -; Genomic_DNA.
DR RefSeq; XP_629153.1; XM_629151.1.
DR AlphaFoldDB; Q54BU8; -.
DR STRING; 44689.Q54BU8; -.
DR PaxDb; 44689-DDB0219853; -.
DR GeneID; 8629210; -.
DR KEGG; ddi:DDB_G0293414; -.
DR dictyBase; DDB_G0293414; -.
DR eggNOG; KOG4751; Eukaryota.
DR HOGENOM; CLU_243471_0_0_1; -.
DR InParanoid; Q54BU8; -.
DR OMA; GFKTGRN; -.
DR PRO; PR:Q54BU8; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR InterPro; IPR015525; BRCA2.
DR InterPro; IPR015252; BRCA2_hlx.
DR InterPro; IPR036315; BRCA2_hlx_sf.
DR InterPro; IPR015187; BRCA2_OB_1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR Pfam; PF09169; BRCA-2_helical; 1.
DR Pfam; PF09103; BRCA-2_OB1; 2.
DR SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 702..775
FT /note="Breast cancer type 2 susceptibility protein helical"
FT /evidence="ECO:0000259|Pfam:PF09169"
FT DOMAIN 779..854
FT /note="BRCA2 OB1"
FT /evidence="ECO:0000259|Pfam:PF09103"
FT DOMAIN 889..987
FT /note="BRCA2 OB1"
FT /evidence="ECO:0000259|Pfam:PF09103"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..338
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..901
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1211..1231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1562..1600
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1038..1066
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..47
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 214..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1562..1599
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1623 AA; 177864 MW; 53731E94F2FCFEBD CRC64;
MKSNSNKREF SSDDDNSNVE SDSSKKTRIS PPSTPQPQTT TSLIPPPVFK GFSTGRGAAV
VISEEKLRLA KKKLSSIGDE DIKDLLPSES GAVDNSNDFL TMTNSNSNNN SNSNNNDTIN
TTATITPTTT SSSPLLQTTT TSSSLSSSSP PPPLPQTTTS SIPPTFKGFS TGRGVAVVIS
EEKLKLAQKK LSSIADEDIK DLLPSEGGVV DNNDFLAMNS SSNNSNGSNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNTT TTTASSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS
SSSSSSSSSS PSLQTTTSSS PPQLLQTTTS SIPTTFKGFS TGRGVAVVIS EEKLKLAQKK
LSSIADEDIK DLLPSEGGAV DNNDFLTMNN SNSNNSNSSH TNTTTTTTTT TTNTTNTTTA
STSNDNSTSR SDDSSAPSSP QPQQNIRAPS PPSSFSSSSS TSSIAPPTTP NRSPVPTSTN
LNSSTATVPQ LTTPTKSKYP LQSPVKKTFV YNPNTTPTKK SFIPPTKSLS PPQQQQTSTV
PPQTNIAPTT TSTFSYPTTP KTAPKILSKP QISTPKKSSF KPPIKSNNTP TTPTTTTTST
TISPASPNGN SKGISPPKSK LNISPSKSTT PINNNNNTNN NNNNNIQKKP IDNRRKLKDL
GRPFLVSCEG LVKNDVLEIT SRNASEYRFE NNGEVKDIGK SKTIGVADLY IYLTKINQSN
AALVSQEWVS NHYGWIVWKL ASMERSFPLE FGGKYLKLQR VVNQLKQRIE IEINQAKRPI
LKKIYERDQP SELPMVLCIS SILDDGYGGG INNNNNPNNP NNNNNNNNCT VENDDGIISM
DDIDITMNDD LETASTSTTI SSTNNANNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNKT
NYIQHPIATI ELTDGWYPIK GALDPFLTQC LKQGKLFVGQ KLYIQNAGIV GQENGISPLE
DGFEQVHLKL FTNSTRRVSW YENLGARKSM FPISLKSIIP GGGTVACLKV EVTHIYKLSF
KETIMGEDGS LKTVITRCEN EEQQYKQQYE SKAEIAREKL LESTSKQLEK KQKEDILMSS
LQEQQQQKLK GKLLPNQQNR VRKIPQSALD QKINHKTISN LSEISDGDSL YAYFLRVIDQ
EGFVDCLSDE QKSLLFSNRD KQYQSLQQQI LDQVDDEMNS NPNFKTRNVK PILSIKIRDL
LIKNDIDQLN NNNPNNINNN NNNNNNPNND YNNILDDDFN NNCNNETILS IESPSYDLMD
TLKESMKLTL HMVNPKKMFY SPFRPTGLSP LQSSHRFNVV PIIDNNIGGG GSGNSQKNLN
TNGLHKKGIQ RLDQFLINGN SIGSECDLVV FILYVGDIKV EETLIKDRKR IDSSRFIYFT
DRSGFIGRIN ITKTTWTTGI TNENGGGGSG SSLINQNNQI YFPFKTGFTL SDSQSNNDNL
SSHNLLNPFM VNNNNNNLPI IHLSNLIFKG VDSNQILLFD GSEFFEHSVK PKSKNIVDLF
DDLKQFIKSS PGLLNLFCFR VNSILNQLST PSQINNIKYN SYSTNSNSNN KIIEKNSLVN
STSNQVNKNN NNNNNNNINN NNNNNIINSN NNEPDEMPSS QDFNFDFDPV FLENSGILFF
IIF
//
