ID Q54C05_DICDI Unreviewed; 1217 AA.
AC Q54C05;
DT 24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=BRCT domain-containing protein {ECO:0000259|PROSITE:PS50172};
GN ORFNames=DDB_G0293300 {ECO:0000313|EMBL:EAL60774.1};
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689 {ECO:0000313|EMBL:EAL60774.1, ECO:0000313|Proteomes:UP000002195};
RN [1] {ECO:0000313|EMBL:EAL60774.1, ECO:0000313|Proteomes:UP000002195}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4 {ECO:0000313|EMBL:EAL60774.1,
RC ECO:0000313|Proteomes:UP000002195};
RX PubMed=15875012; DOI=10.1038/nature03481;
RG The Dictyostelium discoideum Sequencing Consortium;
RA Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S.,
RA White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G.,
RA Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L.,
RA Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H.,
RA Noegel A.A., Barrell B., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAL60774.1}.
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DR EMBL; AAFI02000201; EAL60774.1; -; Genomic_DNA.
DR RefSeq; XP_629186.1; XM_629184.1.
DR AlphaFoldDB; Q54C05; -.
DR STRING; 44689.Q54C05; -.
DR PaxDb; 44689-DDB0191863; -.
DR GeneID; 8629145; -.
DR KEGG; ddi:DDB_G0293300; -.
DR dictyBase; DDB_G0293300; -.
DR eggNOG; KOG4362; Eukaryota.
DR HOGENOM; CLU_269108_0_0_1; -.
DR InParanoid; Q54C05; -.
DR OMA; DKQQSQD; -.
DR Reactome; R-DDI-3108214; SUMOylation of DNA damage response and repair proteins.
DR PRO; PR:Q54C05; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0070531; C:BRCA1-A complex; IBA:GO_Central.
DR GO; GO:0031436; C:BRCA1-BARD1 complex; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IBA:GO_Central.
DR GO; GO:0035067; P:negative regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0035066; P:positive regulation of histone acetylation; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR PANTHER; PTHR13763:SF11; BRCT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR PROSITE; PS50172; BRCT; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002195}.
FT DOMAIN 999..1076
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 1095..1199
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 19..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 920..963
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 173..218
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 19..61
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..164
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..465
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..842
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..889
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1217 AA; 136859 MW; A0BA8B36763B71D3 CRC64;
MDTLTKNSSD LSQMLDPEYF KSQSSGDSNN QNNNNNNNNN NNNNNNNNII DVNNNNNNIK
DSPKKKTVRF TSQVEFVEPS QSQNNNNNQN NNNNNNNSSP DINMFDINNN NNIFDVFQDD
IPNSFMLSVI DGSQQIIFNE EDDSEEIQQS LSQQQQQLSS SSSLDNYLLD SSLQQQQQQQ
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQKQLSIELR DDEYYQSISL PIWDAVTSQD
PKMVMKFGKI KRKRGIVIDN RRKKVPDITI DDLMKKDLLR IGDTLCYCIG GVNHFALLLR
DGYIEYDSLR LPSVHAFVIH VLSNLEKNKK FRWFSPWDSV SVRGKSLNFI RSIFQSKFYK
GGDNIIYQYE PTTATTIIIK KQESPIKSSS PQKNILKESP SPSKNLKRTL DNTDNSQNLN
NNNNNNNNNN NNNNNEKDIS DKNSKDDNDD DGDKITKKQK TDDNIENNGK QQMAVDDEST
QSIQPVLIDD ESTQKIIEQK DENEKVEKEK EKAEKEDDEA TQAMADNLNN EYDNSPTIPM
TTMECVRANL NTGFRDNDQD EDENENENEN KKVTSKNNSE STLQNSNSDL PIIYSSPNYQ
QNKFQTPKTP APSPSSTQDH FNRPTIEQPS SPYKSPSKSQ QQASQKSSQQ QQSQQQSPSK
SQEQQASQKL SQQHQSPSKS QEQQTSQKSS QQQQSQQQSP SKSQVSQQSL SHQLTQLQQS
PAKSQEQSPA KSQQQQQSTS SLLNHTISPK QSQNNTNPDS PYSSISLHQP IFVTPSPRGS
NMGSIVSNGG GSGGSSGSSS ISGSISSSSD GGLNHQQSQS SQSSQNSSSS SSSSSIFSIP
AGQKPPTPSP LPSIQPSLPI QNTTTATNQS SQLGSSNNIN SNSNNHSNTY DELRSFQIPQ
SQNNFEDSQQ TLDVDQQPSQ YLSPKKVSQH SQQKKNQLSQ QKSLSQQQLS QQQHQSSSQQ
QQQIIIEKEE NISSPLNKSK IELPIIIATG LTGLMQLHIH SLCSAIGGKL VTEFNDQVTH
VVCSTLDGDG SKENLAKRTI KYQMGIGRGG LWLVSFDWIL ESLNENQWVN ESEFEIQGDS
IGLGSPLKSR QQLFETKRLF YGQSFYLAGE FQSPSRQEIT SVIKSSGGIV LDQLPPKPQN
LNEMLQSTCT VICHPLLSSI DQSLIQTIYL STKHIPISFS WIFDSISKYK LLPKDNYYQY
PNSNNSKFKI NDPSVAY
//
