ID Y2056_DICDI Reviewed; 1823 AA.
AC Q54DS4;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE RecName: Full=WD repeat-containing protein DDB_G0292056;
GN ORFNames=DDB_G0292056;
OS Dictyostelium discoideum (Social amoeba).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
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DR EMBL; AAFI02000187; EAL61384.1; -; Genomic_DNA.
DR RefSeq; XP_629798.1; XM_629796.1.
DR AlphaFoldDB; Q54DS4; -.
DR SMR; Q54DS4; -.
DR STRING; 44689.Q54DS4; -.
DR PaxDb; 44689-DDB0184193; -.
DR EnsemblProtists; EAL61384; EAL61384; DDB_G0292056.
DR GeneID; 8628476; -.
DR KEGG; ddi:DDB_G0292056; -.
DR dictyBase; DDB_G0292056; -.
DR eggNOG; KOG0309; Eukaryota.
DR HOGENOM; CLU_237570_0_0_1; -.
DR InParanoid; Q54DS4; -.
DR OMA; NTLIWDI; -.
DR Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q54DS4; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0035859; C:Seh1-associated complex; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IBA:GO_Central.
DR GO; GO:0035591; F:signaling adaptor activity; IBA:GO_Central.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; IBA:GO_Central.
DR CDD; cd16692; mRING-H2-C3H3C2_WDR59; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR049567; WDR59-like.
DR InterPro; IPR039456; WDR59_mRING-H2-C3H3C2.
DR InterPro; IPR049566; WDR59_RTC1-like_RING_Znf.
DR PANTHER; PTHR46170; GATOR COMPLEX PROTEIN WDR59; 1.
DR PANTHER; PTHR46170:SF1; GATOR COMPLEX PROTEIN WDR59; 1.
DR Pfam; PF00400; WD40; 2.
DR Pfam; PF17120; zf-RING_16; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1823
FT /note="WD repeat-containing protein DDB_G0292056"
FT /id="PRO_0000356851"
FT REPEAT 138..177
FT /note="WD 1"
FT REPEAT 182..222
FT /note="WD 2"
FT REPEAT 228..267
FT /note="WD 3"
FT REPEAT 270..310
FT /note="WD 4"
FT REPEAT 312..354
FT /note="WD 5"
FT REPEAT 360..405
FT /note="WD 6"
FT REPEAT 1207..1250
FT /note="WD 7"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 418..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 530..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 714..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 966..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1014..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1122..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1264..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1697..1725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1764..1823
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..770
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1790..1823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1823 AA; 203124 MW; 78028A2F39DF2773 CRC64;
MTYNNNNNYL APPLMTSTST STSTSTPTST KTSPLNTSSS SNILKSNSRN PSPNNPTNIG
NSSGGGGVSS NNSNNIVYSN SNNINTSTFH YNFNVKFNEI VNSIAVNRAG TLVCLGGKKS
LQVVDLELLK SVRNIPQQSK WEVGVVDWNS QSPNLVASSS NQDTFIWDIE NPKYPLLGQF
SSHQRAISDL SWSLFDNNIL ATTSADSFVN IWDLRTPKKA VKFKSLKSHI LGAIQVKWNR
FNSNVLASAH ESYLMIWDIR KDSQELNTAV HSAKVYGIDW SHRDEKEILT CSQDKTVKIW
NYPSPKPKST IITSNPILRA KYLPLGSGGI VTISDRGENH IRLWDSATSD YSTPVETFIG
HTDNVRSFDF RVRSSQNDND IQIVSWSKDQ YLRLWKLDDH LKDLFNIEYI PFTPLNLPTT
TTTTTTATTT TTNNSTSEML NESTDNNNNT NSLNSSTLLS TPNLESSINS LNMELTIEQQ
QLDDSNTPKD LEYELKIIQS KVIDKYLKIE QVNLFKRTCV VICTIPNNYQ PDDDNNNNNL
NNLNNNNNTQ DNIDNNDDNN NNELIDSTTV QIRFSFPSLY PSTYPNLEFI PHACTTPLKT
NLLIKSTLNE LCAFKSSQSK NCFEQCLIEL VKLVKQYILD EKPKNTSINI TETNNNNNNH
NNSVQNNNNN NNNNNNNNNN SGGGFLKNVF SKSSKAVEVV KQPFINLRNS SGRIDISQQQ
QQQQQQQAAT TSTSSSSSSS SNTQQQQQFL TATVSNKGGT VLSKSPTSPR MFEQYRPGKT
NKTNEIIFLN NYKDSNEEQL PLSPILTNLN NNSNNNSGSG GGGSSNMNAS ITTSTTTNDQ
VSLSVHRNSY RIQENYPCPR LCGAVFGGCG KLIVFRNTII TNIPNNNKNS DNSNNNNSSS
SNKNSDNSNN SNNNSNNTNS SSSSNNGGIA NVGGGSSSTS SLIHHHLQHL HLNQPQLNLL
SLSLSSSSSS ISDTTNNTSN TTQNIQNTTK NINPPRTYKE LLNILSTTNN TIKNNITGNN
NINSNSNTTN NLTSPNPNRL NRLNEKQPYS SSPFNDNPLI NDYKNNIFGT PSTSHSFLAS
PQPSSPISFM NHIDTLLDDS ENNLMTMDNN NNNNIVNDEE TQQLVTSSSP TFSKSSLNNI
NNTTNNSNNN SSNSNNNSNS NNNNNNNNNN NNVNNNNDNN NGNGKSLQKT MKIIDISTLS
LLNVNLANSY ILSGKPVEEI CKYNSELAEK ENRKDLVKLW NTLGMITDSK LYLKQLINQQ
QQQSHFGFSG SSGSTGMGGS SSTGIASSTG SNSIRRPTKL ESSLHQSISM SNLGQIPSSA
SSSYSQTSPS LPYNQLYHQT TLQTPSSPSS QQQQIQFYQQ QALQLQQQQQ QQQQQQREIQ
FKQTQLIQQA QIEDNGWPNH ALGRKLVKSL IDYYKKLEDV QTLATISCIL ILAANQLQKL
KNGESITSIG SSSSSSSSSL ASSPLTFSAG GGGGGSYSPM FNFSAISISA PMGIDDMVSK
QKGHLYNYYG QQQHSHYHHG YQHHNIHQTY GSHPNDVITY DPNLCLLDPN NSKIYDYYRQ
QYSDLLYRWG LLEKRAEVLK YIQHKEVDKG INFSIECIKC NRKLNNFYCN NCKIYAVKCS
ICNISVRGLS SFCLYCGHGG HTNHIKGWFE KQTKCPTGCG CTCSFNLPFI QQQQYQQQLQ
QQQQQLQQQL QLQQTQQQQP QHYQQHRHSM SGTSHYHQQQ PHTHNYQQHI SSYAHTTYQP
HTPRNNGQPV LPQQRRYSIS TFDPQQEQDH EKFNHGGGSG GGDAIFHDIL FSPNSSSSSS
SYQQQTKNSH QYHHPSNPYM FSN
//
